Purpose: This systematic review, conducted per PRISMA guidance, evaluated clinical outcomes of titanium-base (TiB) versus multi-unit (MU) abutments in immediate-loading dental implant protocols, focusing on implant survival, prosthetic and biological complications, and patient-reported outcomes.
Methods: PubMed and Scopus were searched for original English-language clinical studies published between 2001 and 2025, including RCTs, cohort studies, and clinical series with at least 12 months of follow-up. Only studies evaluating TiB and MU abutments in immediate-loading protocols were included. Due to heterogeneity in study designs, case selection, outcome measures, and follow-up duration, a narrative descriptive synthesis was performed without pooled statistical analysis.
Results: Seventeen clinical studies met the inclusion criteria. Both TiB and MU abutments showed high implant survival rates, generally in the high 90 s. TiB abutments performed well in single-tooth anterior restorations, showing fewer mechanical complications and better esthetic ratings. MU abutments were predominantly used in full-arch cases, demonstrating reliable long-term function but with higher mechanical maintenance needs. Marginal bone loss remained within acceptable limits across studies. Patient-reported outcomes were inconsistently assessed, though TiB tended to score higher for esthetics and MU for functional comfort.
Conclusions: Both TiB and MU abutments effectively support immediate loading when primary stability and proper prosthetic planning are achieved. TiB may be preferable for esthetic single-tooth cases, while MU abutments remain suitable for full-arch rehabilitation. The limited number of head-to-head studies highlights the need for well-designed randomized trials with standardized outcomes and validated patient-reported measures.
{"title":"What is the impact of titanium base versus multi-unit abutments on immediate loading outcomes: a systematic review.","authors":"Hossein Salehivaziri, Sahar Molaei, Soroush Kazemi, Narges Shojaei","doi":"10.1007/s44445-025-00114-y","DOIUrl":"10.1007/s44445-025-00114-y","url":null,"abstract":"<p><strong>Purpose: </strong>This systematic review, conducted per PRISMA guidance, evaluated clinical outcomes of titanium-base (TiB) versus multi-unit (MU) abutments in immediate-loading dental implant protocols, focusing on implant survival, prosthetic and biological complications, and patient-reported outcomes.</p><p><strong>Methods: </strong>PubMed and Scopus were searched for original English-language clinical studies published between 2001 and 2025, including RCTs, cohort studies, and clinical series with at least 12 months of follow-up. Only studies evaluating TiB and MU abutments in immediate-loading protocols were included. Due to heterogeneity in study designs, case selection, outcome measures, and follow-up duration, a narrative descriptive synthesis was performed without pooled statistical analysis.</p><p><strong>Results: </strong>Seventeen clinical studies met the inclusion criteria. Both TiB and MU abutments showed high implant survival rates, generally in the high 90 s. TiB abutments performed well in single-tooth anterior restorations, showing fewer mechanical complications and better esthetic ratings. MU abutments were predominantly used in full-arch cases, demonstrating reliable long-term function but with higher mechanical maintenance needs. Marginal bone loss remained within acceptable limits across studies. Patient-reported outcomes were inconsistently assessed, though TiB tended to score higher for esthetics and MU for functional comfort.</p><p><strong>Conclusions: </strong>Both TiB and MU abutments effectively support immediate loading when primary stability and proper prosthetic planning are achieved. TiB may be preferable for esthetic single-tooth cases, while MU abutments remain suitable for full-arch rehabilitation. The limited number of head-to-head studies highlights the need for well-designed randomized trials with standardized outcomes and validated patient-reported measures.</p>","PeriodicalId":47246,"journal":{"name":"Saudi Dental Journal","volume":"38 2","pages":"13"},"PeriodicalIF":2.3,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12860775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-27DOI: 10.1007/s44445-025-00116-w
S Al Mutalaq, R O Braimah, H Alshareef, M Alqadi, A S Alwalah, A N Almerdef, S S Albaaltahin
Canine teeth are essential to dentofacial aesthetics and functional harmony. When impacted they impair both form and function leading to psychological distress and poor health-related quality of life. This study investigates the approaches to managing impacted canines in the southern region of Najran, Kingdom of Saudi Arabia. This was a retrospective study with data collection from Najran Specialty Regional Dental Center in Najran, Kingdom of Saudi Arabia from 2020 to 2024. Clinical record data extracted include age, sex, radiographs, position of impacted canine, location of impacted canine and management protocol. The data were analyzed using IBM SPSS Statistics for IOS Version 25 (Armonk, NY: IBM Corp). P-value ≤ 0.05 was considered statistically significant. A total of 98 patients comprising 44 males (44.9%) and 54 females (55.1%) with impacted canines were managed during the study period. Age ranged from 13 to 30 years with mean ± SD age of 19.3 ± 3.3 years. Age group 16-20 years were in the majority (56 (57.1%)) while age group 26-30 were the least (3 (3.1%)). The majority of the impacted canines were located in the maxilla (85 (86.7%). Considering, management protocol, the majority (57 (58.2%)) of the patients with impacted canine were treated by non-surgical canine exposure. Most of our patients are young adults with the majority having maxillary canine impaction in the palatal location. Our favorite option is non-surgical canine exposure. Treatment durations ranges from two to four years with the majority in the 2.5 to 3 years.
犬齿对牙面美观和功能和谐至关重要。当受到影响时,它们会损害形式和功能,导致心理困扰和与健康相关的生活质量差。本研究调查了沙特阿拉伯王国纳季兰南部地区受影响犬类的管理方法。这是一项回顾性研究,收集了2020年至2024年沙特阿拉伯王国纳季兰纳季兰专业区域牙科中心的数据。提取的临床记录数据包括年龄、性别、x线片、患牙位置、患牙位置和处理方案。使用IBM SPSS Statistics for IOS Version 25 (Armonk, NY: IBM Corp .)对数据进行分析。p值≤0.05认为有统计学意义。在研究期间共处理了98例患患犬,其中男性44例(44.9%),女性54例(55.1%)。年龄13 ~ 30岁,平均±SD年龄19.3±3.3岁。16 ~ 20岁以56例(57.1%)居多,26 ~ 30岁最少(3例(3.1%))。多数阻生犬位于上颌骨(85只,占86.7%)。考虑到治疗方案,大多数(57例(58.2%))患者采用非手术犬暴露治疗。我们的大多数患者是年轻的成年人,大多数在腭位置有上颌犬牙嵌塞。我们最喜欢的选择是非手术犬暴露。治疗持续时间从2年到4年不等,大多数在2.5年到3年之间。
{"title":"Surgical versus non-surgical canine exposure in the management of impacted canines in Orthodontic patients: retrospective analysis in Southern region of Najran, Kingdom of Saudi Arabia.","authors":"S Al Mutalaq, R O Braimah, H Alshareef, M Alqadi, A S Alwalah, A N Almerdef, S S Albaaltahin","doi":"10.1007/s44445-025-00116-w","DOIUrl":"10.1007/s44445-025-00116-w","url":null,"abstract":"<p><p>Canine teeth are essential to dentofacial aesthetics and functional harmony. When impacted they impair both form and function leading to psychological distress and poor health-related quality of life. This study investigates the approaches to managing impacted canines in the southern region of Najran, Kingdom of Saudi Arabia. This was a retrospective study with data collection from Najran Specialty Regional Dental Center in Najran, Kingdom of Saudi Arabia from 2020 to 2024. Clinical record data extracted include age, sex, radiographs, position of impacted canine, location of impacted canine and management protocol. The data were analyzed using IBM SPSS Statistics for IOS Version 25 (Armonk, NY: IBM Corp). P-value ≤ 0.05 was considered statistically significant. A total of 98 patients comprising 44 males (44.9%) and 54 females (55.1%) with impacted canines were managed during the study period. Age ranged from 13 to 30 years with mean ± SD age of 19.3 ± 3.3 years. Age group 16-20 years were in the majority (56 (57.1%)) while age group 26-30 were the least (3 (3.1%)). The majority of the impacted canines were located in the maxilla (85 (86.7%). Considering, management protocol, the majority (57 (58.2%)) of the patients with impacted canine were treated by non-surgical canine exposure. Most of our patients are young adults with the majority having maxillary canine impaction in the palatal location. Our favorite option is non-surgical canine exposure. Treatment durations ranges from two to four years with the majority in the 2.5 to 3 years.</p>","PeriodicalId":47246,"journal":{"name":"Saudi Dental Journal","volume":"38 2","pages":"12"},"PeriodicalIF":2.3,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12847586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146054448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-26DOI: 10.1007/s44445-025-00107-x
Eman A Bakhurji, Rasha Al Sheikh, Abdullah A Alamri, Firas A Alothman, Khalid E Aldossary, Fayez R Alghamdi, Osama S Alghamdi
The aim of this study was to evaluate the shear bond strength and tooth discoloration of resin-modified glass ionomer cement (RMGIC) and high-viscosity glass ionomer cement (HGIC) restorations in primary teeth treated with either nano-silver fluoride (NSF) or silver diamine fluoride (SDF). Sixty-six primary molars with dentin caries were randomly assigned to six groups of 11 teeth each: two NSF-treated groups (one RMGIC, one HGIC) and two SDF-treated groups (one RMGIC, one HGIC). Two additional control groups received direct RMGIC and HGIC restorations, respectively. All samples were tested for tooth discoloration using a spectrophotometer before and after the thermocycling aging process (20,000 cycles). Shear bond strength was compared between the groups. Kruskal-Wallis test with a P-value of < 0.05 was used for statistical significance. The samples treated with SDF and restored with RMGIC exhibited the highest ΔE value (mean ± standard deviation (SD) of 8.27 ± 6.51). In contrast, the samples treated with NSF and restored with RMGIC demonstrated the lowest ΔE value (mean ± SD of 1.45 ± 0.77). No statistically significant differences were found between the groups in the shear bond strength test. NSF provided a better color masking effect compared to SDF when using RMGIC without visible black stains through the restoration. Additionally, neither NSF nor SDF affected the shear bond strength of either type of restoration applied to them. NSF may be preferred over SDF in cases where aesthetics is a priority, with similar bond strength and enhanced color matching.
{"title":"Evaluation of SMART technique using Nano-silver fluoride and Silver Diamine Fluoride; evaluation of tooth discoloration and shear bond strength in primary molars.","authors":"Eman A Bakhurji, Rasha Al Sheikh, Abdullah A Alamri, Firas A Alothman, Khalid E Aldossary, Fayez R Alghamdi, Osama S Alghamdi","doi":"10.1007/s44445-025-00107-x","DOIUrl":"10.1007/s44445-025-00107-x","url":null,"abstract":"<p><p>The aim of this study was to evaluate the shear bond strength and tooth discoloration of resin-modified glass ionomer cement (RMGIC) and high-viscosity glass ionomer cement (HGIC) restorations in primary teeth treated with either nano-silver fluoride (NSF) or silver diamine fluoride (SDF). Sixty-six primary molars with dentin caries were randomly assigned to six groups of 11 teeth each: two NSF-treated groups (one RMGIC, one HGIC) and two SDF-treated groups (one RMGIC, one HGIC). Two additional control groups received direct RMGIC and HGIC restorations, respectively. All samples were tested for tooth discoloration using a spectrophotometer before and after the thermocycling aging process (20,000 cycles). Shear bond strength was compared between the groups. Kruskal-Wallis test with a P-value of < 0.05 was used for statistical significance. The samples treated with SDF and restored with RMGIC exhibited the highest ΔE value (mean ± standard deviation (SD) of 8.27 ± 6.51). In contrast, the samples treated with NSF and restored with RMGIC demonstrated the lowest ΔE value (mean ± SD of 1.45 ± 0.77). No statistically significant differences were found between the groups in the shear bond strength test. NSF provided a better color masking effect compared to SDF when using RMGIC without visible black stains through the restoration. Additionally, neither NSF nor SDF affected the shear bond strength of either type of restoration applied to them. NSF may be preferred over SDF in cases where aesthetics is a priority, with similar bond strength and enhanced color matching.</p>","PeriodicalId":47246,"journal":{"name":"Saudi Dental Journal","volume":"38 2","pages":"11"},"PeriodicalIF":2.3,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12834854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146047038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-23DOI: 10.1007/s44445-025-00093-0
Christoph Matthias Schoppmeier, Malin Janson, Li Sun, Gustav Leo Classen, Anna Greta Barbe
Purpose: Nickel-titanium (NiTi) instruments have advanced root canal preparation through enhanced precision. Thermal pretreatment improves both flexibility and cyclic fatigue resistance (CFR). While irrigating solutions are essential for decontamination, they may also affect the properties of heat-treated NiTi instruments. This study aimed to evaluate the impact of different irrigating solutions on the cyclic fatigue resistance of heat-treated NiTi files.
Methods: Four heat-treated reciprocating NiTi-files were analyzed: EdgeOne R-Utopia, Reciproc Blue, Procodile Q and CC One Blue. Files were immersed (5 min; 37 °C and 60 °C) in 5.25% sodium hypochlorite (NaOCl), 17% ethylenediaminetetraacetic acid (EDTA), 96% ethanol, NaOCl + EDTA, distilled water, or left in a no-immersion control group. CFR was measured in an artificial root canal (60° curvature, 5 mm radius), and fragment length (FL) was documented. The surface features of the fragments were assessed through scanning electron microscopy.
Results: File system, irrigating solution, and temperature significantly influenced CFR (p < 0.001). Across all immersion conditions, the CFR reached its highest value with Procodile Q (37 °C distilled water) and its lowest with EdgeOne R-Utopia (60 °C NaOCl + EDTA). EDTA reduced CFR across all files, particularly at elevated temperatures and when combined with NaOCl. Microscopy revealed micropitting and roughened surfaces, particularly on CC One Blue (60 °C NaOCl), as well as material degradation and heterogeneous surfaces with NaOCl + EDTA.
Conclusions: Heat-treated NiTi instruments are influenced in their mechanical and metallurgical behavior by the chemical and thermal impact of irrigating solutions. Heated EDTA and NaOCl + EDTA were detrimental, while Procodile Q demonstrated the highest CFR. Within the limitations of this study, exposure to irrigating solutions, particularly heated EDTA and NaOCl + EDTA, reduced the cyclic fatigue resistance of heat-treated NiTi files. Clinically, prudent selection and temperature control of irrigants may help preserve instrument performance and reduce the risk of file fracture during root canal preparation.
{"title":"Do irrigating solutions influence the cyclic fatigue resistance of heat-treated NiTi instruments? an in vitro study.","authors":"Christoph Matthias Schoppmeier, Malin Janson, Li Sun, Gustav Leo Classen, Anna Greta Barbe","doi":"10.1007/s44445-025-00093-0","DOIUrl":"10.1007/s44445-025-00093-0","url":null,"abstract":"<p><strong>Purpose: </strong>Nickel-titanium (NiTi) instruments have advanced root canal preparation through enhanced precision. Thermal pretreatment improves both flexibility and cyclic fatigue resistance (CFR). While irrigating solutions are essential for decontamination, they may also affect the properties of heat-treated NiTi instruments. This study aimed to evaluate the impact of different irrigating solutions on the cyclic fatigue resistance of heat-treated NiTi files.</p><p><strong>Methods: </strong>Four heat-treated reciprocating NiTi-files were analyzed: EdgeOne R-Utopia, Reciproc Blue, Procodile Q and CC One Blue. Files were immersed (5 min; 37 °C and 60 °C) in 5.25% sodium hypochlorite (NaOCl), 17% ethylenediaminetetraacetic acid (EDTA), 96% ethanol, NaOCl + EDTA, distilled water, or left in a no-immersion control group. CFR was measured in an artificial root canal (60° curvature, 5 mm radius), and fragment length (FL) was documented. The surface features of the fragments were assessed through scanning electron microscopy.</p><p><strong>Results: </strong>File system, irrigating solution, and temperature significantly influenced CFR (p < 0.001). Across all immersion conditions, the CFR reached its highest value with Procodile Q (37 °C distilled water) and its lowest with EdgeOne R-Utopia (60 °C NaOCl + EDTA). EDTA reduced CFR across all files, particularly at elevated temperatures and when combined with NaOCl. Microscopy revealed micropitting and roughened surfaces, particularly on CC One Blue (60 °C NaOCl), as well as material degradation and heterogeneous surfaces with NaOCl + EDTA.</p><p><strong>Conclusions: </strong>Heat-treated NiTi instruments are influenced in their mechanical and metallurgical behavior by the chemical and thermal impact of irrigating solutions. Heated EDTA and NaOCl + EDTA were detrimental, while Procodile Q demonstrated the highest CFR. Within the limitations of this study, exposure to irrigating solutions, particularly heated EDTA and NaOCl + EDTA, reduced the cyclic fatigue resistance of heat-treated NiTi files. Clinically, prudent selection and temperature control of irrigants may help preserve instrument performance and reduce the risk of file fracture during root canal preparation.</p>","PeriodicalId":47246,"journal":{"name":"Saudi Dental Journal","volume":"38 2","pages":"10"},"PeriodicalIF":2.3,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12827828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-23DOI: 10.1007/s44445-026-00121-7
Abdulrazzaq Hammal, Heba Al-Hamed Al-Duihi
The global rise in antibiotic resistance among oral pathogens necessitates exploring natural and innovative alternatives for dental caries management. This study aimed to synthesize, characterize, and evaluate a novel clove extract-loaded nano-hydroxyapatite composite (nHA-CE) for its dual functionality: biomimetic remineralization and enhanced antimicrobial activity against dental caries-associated microbes. Nano-hydroxyapatite (nHA) was synthesized via wet chemical precipitation and characterized using XRD, FTIR, AFM, and DLS. Clove extract was obtained by ethanolic extraction and analyzed by GC-MS. The nHA-CE composite was prepared, and its antibacterial efficacy was tested against oral pathogens using agar well diffusion and compared to standard antibiotics. The nHA particles were spherical, with an average size of ~ 80 nm. Eugenol (72.5%) was the major component in clove extract. The nHA-CE composite showed significantly larger inhibition zones against all pathogens, especially Streptococcus mutans (50 ± 0.8 mm), outperforming conventional antibiotics. The composite also exhibited sustained eugenol release and maintained stability over 30 days. The nHA-CE composite is a promising biomaterial for dental caries prevention, combining effective remineralization with potent, broad-spectrum antimicrobial activity, offering a natural alternative to conventional treatments.
{"title":"Preparation of clove extract-loaded nano-hydroxyapatite for combating dental caries-associated microbes.","authors":"Abdulrazzaq Hammal, Heba Al-Hamed Al-Duihi","doi":"10.1007/s44445-026-00121-7","DOIUrl":"10.1007/s44445-026-00121-7","url":null,"abstract":"<p><p>The global rise in antibiotic resistance among oral pathogens necessitates exploring natural and innovative alternatives for dental caries management. This study aimed to synthesize, characterize, and evaluate a novel clove extract-loaded nano-hydroxyapatite composite (nHA-CE) for its dual functionality: biomimetic remineralization and enhanced antimicrobial activity against dental caries-associated microbes. Nano-hydroxyapatite (nHA) was synthesized via wet chemical precipitation and characterized using XRD, FTIR, AFM, and DLS. Clove extract was obtained by ethanolic extraction and analyzed by GC-MS. The nHA-CE composite was prepared, and its antibacterial efficacy was tested against oral pathogens using agar well diffusion and compared to standard antibiotics. The nHA particles were spherical, with an average size of ~ 80 nm. Eugenol (72.5%) was the major component in clove extract. The nHA-CE composite showed significantly larger inhibition zones against all pathogens, especially Streptococcus mutans (50 ± 0.8 mm), outperforming conventional antibiotics. The composite also exhibited sustained eugenol release and maintained stability over 30 days. The nHA-CE composite is a promising biomaterial for dental caries prevention, combining effective remineralization with potent, broad-spectrum antimicrobial activity, offering a natural alternative to conventional treatments.</p>","PeriodicalId":47246,"journal":{"name":"Saudi Dental Journal","volume":"38 2","pages":"9"},"PeriodicalIF":2.3,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12827825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146031264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-22DOI: 10.1007/s44445-025-00112-0
Mohammed Assiri, Hesham Almoallim, Maryam Alhindi, Mohammed Alkindi, Saleh Alshihri, Tariq Wahass
<p><p>The aim of this research is to compare the regenerative capability and the bone regeneration rates of i-PRF mixed with β-TCP vs. PRF mixed with β-TCP when used for GBR within critical size defects created in metacarpal bone in a goat model, using (micro-CT) analysis. Eighteen male Najdi strain goats with a mean body weight of 30 ± 2 kg and a mean age of 8 ± 1.5 months were selected. Under a full-sterilized environment, all animals underwent the same surgical procedure in the left metacarpal bone. Four critical size defects were created in the lateral aspect of the left metacarpal bone as following: Group I (Negative control group): The 1st proximal critical size defect was allowed to heal spontaneously. Group II (βeta-Tri-calcium phosphate - β-TCP): The 2nd following critical size defect was treated with β-TCP. Group III (β-TCP + PRF group): The 3rd following critical size defect was treated with β-TCP mixed with PRF. Group IV (β-TCP + i-PRF group): The 4th following critical size defect was treated with β-TCP mixed with i-PRF. Under general anesthesia and veterinary supervision, the four (monocortical) critical size defects were created on the left metacarpal bone using bone trephine bur with an outer diameter of 6.1 mm and inner diameter of 5.25 mm. The critical size defects were treated according to the groups mentioned above. The eighteen goats were allocated to three sacrifice time points (2, 5, and 8 weeks; n = 6 per time point). Four defects per goat were analyzed at each time point using micro-CT scan. A quantitative assessment of new bone formation (Bone Volume for Newly Formed Bone) (BV-NFB), a qualitative assessment for mineral density (Bone Mineral Density for Newly Formed Bone) (BMD-NFB), β-TCP Volume (TCPV), β-TCP Mineral Density (TCPMD), Trabecular Thickness (Tb-Th), Trabecular Separation (Th-Sp) and Trabecular Number (Th-No.) assessments were performed at the 8th week scan cycle. The mean values of BV-NFB were 39.455 mm<sup>3</sup>, 58.995 mm<sup>3</sup>, 62.665 mm<sup>3</sup> and 80.083 mm<sup>3</sup> by the 8th week for group I, II, III and IV respectively. Along with the mean values of BMD-NFB were 0.425 g/mm<sup>3</sup>, 0.799 g/mm<sup>3</sup>, 0.802 g/mm<sup>3</sup> and 0.822 g/mm<sup>3</sup> respectively. By the 8th week, the mean values of the remaining TCPV were 24.972 mm<sup>3</sup>, 22.013 mm<sup>3</sup> and 15.319 mm3 for groups II, III and IV respectively, and the mean values of TCPMD were 0.734 g/mm<sup>3</sup>, 0.725 g/mm<sup>3</sup> and 0.720 g/mm<sup>3</sup> respectively. The means of NFBV, NFBMD, (Tb-Th), (Th-Sp) and (Th-No.) in β-TCP + i-PRF group were significantly higher than the other groups during the 2nd, 5th and 8th week. In our study, the combination of β-TCP particles and i-PRF can promote regenerative bone healing in comparison to β-TCP alone or β-TCP with PRF within a critical size defect in metacarpal bone of goats. The Micro-CT results revealed that a mixture of β-TCP particles and i-PRF show gr
{"title":"Injectable platelet rich fibrin (i-PRF) versus platelet rich fibrin (PRF) both mixed with beta-tri calcium phosphate in bone regeneration using metacarpal bone defect in goats: micro CT comparative study.","authors":"Mohammed Assiri, Hesham Almoallim, Maryam Alhindi, Mohammed Alkindi, Saleh Alshihri, Tariq Wahass","doi":"10.1007/s44445-025-00112-0","DOIUrl":"10.1007/s44445-025-00112-0","url":null,"abstract":"<p><p>The aim of this research is to compare the regenerative capability and the bone regeneration rates of i-PRF mixed with β-TCP vs. PRF mixed with β-TCP when used for GBR within critical size defects created in metacarpal bone in a goat model, using (micro-CT) analysis. Eighteen male Najdi strain goats with a mean body weight of 30 ± 2 kg and a mean age of 8 ± 1.5 months were selected. Under a full-sterilized environment, all animals underwent the same surgical procedure in the left metacarpal bone. Four critical size defects were created in the lateral aspect of the left metacarpal bone as following: Group I (Negative control group): The 1st proximal critical size defect was allowed to heal spontaneously. Group II (βeta-Tri-calcium phosphate - β-TCP): The 2nd following critical size defect was treated with β-TCP. Group III (β-TCP + PRF group): The 3rd following critical size defect was treated with β-TCP mixed with PRF. Group IV (β-TCP + i-PRF group): The 4th following critical size defect was treated with β-TCP mixed with i-PRF. Under general anesthesia and veterinary supervision, the four (monocortical) critical size defects were created on the left metacarpal bone using bone trephine bur with an outer diameter of 6.1 mm and inner diameter of 5.25 mm. The critical size defects were treated according to the groups mentioned above. The eighteen goats were allocated to three sacrifice time points (2, 5, and 8 weeks; n = 6 per time point). Four defects per goat were analyzed at each time point using micro-CT scan. A quantitative assessment of new bone formation (Bone Volume for Newly Formed Bone) (BV-NFB), a qualitative assessment for mineral density (Bone Mineral Density for Newly Formed Bone) (BMD-NFB), β-TCP Volume (TCPV), β-TCP Mineral Density (TCPMD), Trabecular Thickness (Tb-Th), Trabecular Separation (Th-Sp) and Trabecular Number (Th-No.) assessments were performed at the 8th week scan cycle. The mean values of BV-NFB were 39.455 mm<sup>3</sup>, 58.995 mm<sup>3</sup>, 62.665 mm<sup>3</sup> and 80.083 mm<sup>3</sup> by the 8th week for group I, II, III and IV respectively. Along with the mean values of BMD-NFB were 0.425 g/mm<sup>3</sup>, 0.799 g/mm<sup>3</sup>, 0.802 g/mm<sup>3</sup> and 0.822 g/mm<sup>3</sup> respectively. By the 8th week, the mean values of the remaining TCPV were 24.972 mm<sup>3</sup>, 22.013 mm<sup>3</sup> and 15.319 mm3 for groups II, III and IV respectively, and the mean values of TCPMD were 0.734 g/mm<sup>3</sup>, 0.725 g/mm<sup>3</sup> and 0.720 g/mm<sup>3</sup> respectively. The means of NFBV, NFBMD, (Tb-Th), (Th-Sp) and (Th-No.) in β-TCP + i-PRF group were significantly higher than the other groups during the 2nd, 5th and 8th week. In our study, the combination of β-TCP particles and i-PRF can promote regenerative bone healing in comparison to β-TCP alone or β-TCP with PRF within a critical size defect in metacarpal bone of goats. The Micro-CT results revealed that a mixture of β-TCP particles and i-PRF show gr","PeriodicalId":47246,"journal":{"name":"Saudi Dental Journal","volume":"38 2","pages":"7"},"PeriodicalIF":2.3,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12824068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146020040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-22DOI: 10.1007/s44445-026-00117-3
Dalia Meisha
Social media data are increasingly used in health research for communication, surveillance, and behavioral insights, and have also been applied to dentistry. The objective of this study is to describe sentiment and emotion patterns in English/Arabic tweets in the X platform about dental pain and summarize care pathways, including home remedies. This is a cross-sectional analysis of public tweets retrieved for three years. After de-duplication and eligibility screening, tweets were classified (sentiment; Ekman emotion categories) and assigned to 11 themes using a large language model with dual human validation. A total of 4,051 tweets were screened, and 659 met the study inclusion criteria. Negative sentiment predominated study tweets. Fear (29.7%) and sadness (19.1%) were the most frequent emotions. Negative sentiment was highest for pain complaints, advice-seeking, emergency access, and post-treatment pain (p < 0.001). Mentions of professional dental care (47.4%) exceeded home-remedy mentions (1.1-17.0%). Arabic tweets trended more negative than English (p = 0.07). Dental pain discourse on X is largely negative and fear-laden, with professional-care mentions outnumbering home remedies; translating these signals into practice suggests prioritizing reassurance, offering triage cues, and directing users to urgent-care pathways.
{"title":"Sentiment and emotion analysis of dental pain posts on X (formerly Twitter).","authors":"Dalia Meisha","doi":"10.1007/s44445-026-00117-3","DOIUrl":"10.1007/s44445-026-00117-3","url":null,"abstract":"<p><p>Social media data are increasingly used in health research for communication, surveillance, and behavioral insights, and have also been applied to dentistry. The objective of this study is to describe sentiment and emotion patterns in English/Arabic tweets in the X platform about dental pain and summarize care pathways, including home remedies. This is a cross-sectional analysis of public tweets retrieved for three years. After de-duplication and eligibility screening, tweets were classified (sentiment; Ekman emotion categories) and assigned to 11 themes using a large language model with dual human validation. A total of 4,051 tweets were screened, and 659 met the study inclusion criteria. Negative sentiment predominated study tweets. Fear (29.7%) and sadness (19.1%) were the most frequent emotions. Negative sentiment was highest for pain complaints, advice-seeking, emergency access, and post-treatment pain (p < 0.001). Mentions of professional dental care (47.4%) exceeded home-remedy mentions (1.1-17.0%). Arabic tweets trended more negative than English (p = 0.07). Dental pain discourse on X is largely negative and fear-laden, with professional-care mentions outnumbering home remedies; translating these signals into practice suggests prioritizing reassurance, offering triage cues, and directing users to urgent-care pathways.</p>","PeriodicalId":47246,"journal":{"name":"Saudi Dental Journal","volume":"38 2","pages":"8"},"PeriodicalIF":2.3,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12827849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146031255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-20DOI: 10.1007/s44445-025-00098-9
J Rujano-Salinas, A Pérez, A Ramirez, Moreno-Garces, A Bernotti, D Machado, Daniel Nastri-de Luca, Carlos Sanchez-Ramirez
This study aimed to evaluate the effects of photobiomodulation therapy (PBM) on post-operative pain and wound healing following the extraction of mandibular third molars. A split-mouth, double-blind, placebo-controlled, randomized clinical trial was conducted at the Faculty of Dentistry, José Antonio Páez University. Patients requiring bilateral surgical extraction of impacted and retained mandibular third molars in comparable anatomical positions were enrolled. Individuals with soft or hard tissue pathologies or systemic inflammatory conditions that could interfere with healing were excluded. One side of the jaw was randomly assigned as the treatment side, whereas the contralateral side served as the control. The treatment side received photobiomodulation (PBM) via a 980 nm diode laser (SOLASE PRO LASER, LAZON®) immediately after surgery and at 24, 48, and 72 h postoperatively. The primary outcome variables were wound healing and pain intensity. Pain was assessed via a visual analog scale (VAS) at 24, 48, 72, and 168 h. Wound healing was clinically evaluated on postoperative days 3, 7, and 14. Comparative analysis was performed via two-way ANOVA and repeated-measures ANOVA. A p value < 0.05 was considered statistically significant. Thirty-seven patients (32.4% male and 67.6% female) aged 22.8 ± 3.6 years participated in this study. VAS results revealed that PBM controlled pain at 24 h (4 ± 3) in comparison with the control group (6 ± 3) (p = 0.002), at 48 h (4 ± 3 and 5 ± 2, respectively) (p = 0.003), and at 72 h (2 ± 2 and 4 ± 2, respectively) (p = 0.004). Wound healing was significantly better on the PBM-treated side on day 3 (2,1 ± 0,2) than on the control side (3,2 ± 0,6) (p = 0.00), at 7 days (1,5 ± 0,5 and 2,5 ± 0,8, respectively) (p = 0.00), and at 14 days (1 ± 0 and 1,8 ± 0,8), respectively (p = 0.00). No adverse effects were reported. PBM with a 980 nm diode laser significantly reduced postoperative pain and enhanced wound healing compared to the contralateral control side, supporting its use as a safe and effective adjunct in third molar surgery.
本研究旨在评估光生物调节疗法(PBM)对下颌第三磨牙拔除术后疼痛和伤口愈合的影响。jos安东尼奥Páez大学牙科学院进行了一项双盲、安慰剂对照、随机临床试验。需要双侧手术拔除相似解剖位置的阻生和保留下颌第三磨牙的患者被纳入研究。有软组织或硬组织病变或全身性炎症可能干扰愈合的个体被排除在外。一侧下颚被随机指定为治疗侧,而对侧下颚作为对照。治疗侧在术后立即及术后24、48和72小时通过980 nm二极管激光器(SOLASE PRO laser, LAZON®)进行光生物调节(PBM)。主要结局变量为伤口愈合和疼痛强度。在24、48、72和168小时通过视觉模拟评分(VAS)评估疼痛。在术后第3、7和14天临床评估伤口愈合情况。比较分析采用双向方差分析和重复测量方差分析。A p值
{"title":"Photobiomodulation as an adjuvant for pain relief and healing pre-orthodontic mandibular third molar surgery: double-blinded randomized clinical trial.","authors":"J Rujano-Salinas, A Pérez, A Ramirez, Moreno-Garces, A Bernotti, D Machado, Daniel Nastri-de Luca, Carlos Sanchez-Ramirez","doi":"10.1007/s44445-025-00098-9","DOIUrl":"10.1007/s44445-025-00098-9","url":null,"abstract":"<p><p>This study aimed to evaluate the effects of photobiomodulation therapy (PBM) on post-operative pain and wound healing following the extraction of mandibular third molars. A split-mouth, double-blind, placebo-controlled, randomized clinical trial was conducted at the Faculty of Dentistry, José Antonio Páez University. Patients requiring bilateral surgical extraction of impacted and retained mandibular third molars in comparable anatomical positions were enrolled. Individuals with soft or hard tissue pathologies or systemic inflammatory conditions that could interfere with healing were excluded. One side of the jaw was randomly assigned as the treatment side, whereas the contralateral side served as the control. The treatment side received photobiomodulation (PBM) via a 980 nm diode laser (SOLASE PRO LASER, LAZON®) immediately after surgery and at 24, 48, and 72 h postoperatively. The primary outcome variables were wound healing and pain intensity. Pain was assessed via a visual analog scale (VAS) at 24, 48, 72, and 168 h. Wound healing was clinically evaluated on postoperative days 3, 7, and 14. Comparative analysis was performed via two-way ANOVA and repeated-measures ANOVA. A p value < 0.05 was considered statistically significant. Thirty-seven patients (32.4% male and 67.6% female) aged 22.8 ± 3.6 years participated in this study. VAS results revealed that PBM controlled pain at 24 h (4 ± 3) in comparison with the control group (6 ± 3) (p = 0.002), at 48 h (4 ± 3 and 5 ± 2, respectively) (p = 0.003), and at 72 h (2 ± 2 and 4 ± 2, respectively) (p = 0.004). Wound healing was significantly better on the PBM-treated side on day 3 (2,1 ± 0,2) than on the control side (3,2 ± 0,6) (p = 0.00), at 7 days (1,5 ± 0,5 and 2,5 ± 0,8, respectively) (p = 0.00), and at 14 days (1 ± 0 and 1,8 ± 0,8), respectively (p = 0.00). No adverse effects were reported. PBM with a 980 nm diode laser significantly reduced postoperative pain and enhanced wound healing compared to the contralateral control side, supporting its use as a safe and effective adjunct in third molar surgery.</p>","PeriodicalId":47246,"journal":{"name":"Saudi Dental Journal","volume":"38 2","pages":"6"},"PeriodicalIF":2.3,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12816496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bone mineral density (BMD) is a critical indicator of skeletal health, with implications for systemic conditions such as osteoporosis and localized oral diseases. Dental radiographs, routinely employed in clinical practice, offer a non-invasive means to assess bone quality, yet their role in quantifying BMD and diagnosing metabolic bone disorders remains underexplored. This systematic review of literature examines the diagnostic efficacy of dental radiographs in evaluating BMD. A comprehensive analysis of existing studies in databases such as PubMed, Scopus, Web of Science, ScienceDirect, and SpringerLink was conducted to identify patterns, methodologies, and gaps in the current understanding of radiographic bone assessment for early detection of osteoporosis. The search covered studies published between January 2001 and August 2025, utilizing a search string including "Dental Radiographs" [Mesh] OR "Panoramic Radiography" [Mesh] OR "Periapical Radiography" OR "Cone-Beam Computed Tomography" [Mesh])AND ("Bone Mineral Density" [Mesh] OR "Osteoporosis" [Mesh]) AND ("DXA" OR "Dual-Energy X-ray Absorptiometry" [Mesh]) AND ("Correlation" OR "Assessment" OR "Evaluation"). Database searching yielded 1,247 records relevant to the study objective. After duplicate removal and meticulous screening, 17 studies met the inclusion criteria and were included in the review. The findings of the reviewed studies indicate that dental radiographs, particularly panoramic and periapical imaging, show moderate correlation with dual-energy X-ray absorptiometry (DXA) in detecting osteoporosis. However, precision varies with imaging technique and anatomical region. Quantitative analyses of trabecular patterns and cortical thickness further suggest that dental radiographs can serve as supplementary tools for early BMD screening, especially in high-risk populations. However, inconsistencies in diagnostic thresholds and limited standardization across studies highlight the need for further research. This review underscores the potential of dental radiographs as accessible screening tools, while emphasizing the need to refine analytical protocols to enhance their reliability in clinical and research settings.
骨矿物质密度(BMD)是骨骼健康的重要指标,对骨质疏松症和局部口腔疾病等全身性疾病有影响。牙科x线片,常规应用于临床实践,提供了一种非侵入性的方法来评估骨质量,但其在量化骨密度和诊断代谢性骨疾病方面的作用仍未得到充分探讨。这篇系统的文献综述探讨了牙科x线片在评估骨密度方面的诊断效果。对PubMed、Scopus、Web of Science、ScienceDirect和SpringerLink等数据库中的现有研究进行了全面分析,以确定模式、方法和目前对骨质疏松症早期检测的放射学骨评估的理解差距。该搜索涵盖了2001年1月至2025年8月之间发表的研究,使用的搜索字符串包括“牙科x线摄影”[Mesh]或“全景x线摄影”[Mesh]或“根尖周围x线摄影”或“锥束计算机断层摄影”[Mesh])和(“骨矿物质密度”[Mesh]或“骨质疏松症”[Mesh])和(“DXA”或“双能x线吸收仪”[Mesh])和(“相关性”或“评估”或“评估”)。数据库检索得到1247条与研究目标相关的记录。在去除重复和仔细筛选后,17项研究符合纳入标准并纳入本综述。所回顾的研究结果表明,牙科x线片,特别是全景和根尖周成像,在检测骨质疏松症方面与双能x线吸收仪(DXA)有中等相关性。然而,精度因成像技术和解剖区域而异。定量分析小梁模式和皮质厚度进一步表明牙科x线片可以作为早期BMD筛查的辅助工具,特别是在高危人群中。然而,诊断阈值的不一致性和有限的标准化强调了进一步研究的必要性。这篇综述强调了牙科x光片作为可获得的筛查工具的潜力,同时强调需要完善分析方案,以提高其在临床和研究环境中的可靠性。
{"title":"The role of dental radiographs in assessing bone mineral density: a systematic review of literature.","authors":"Chalini Sundar, Sundar Ramalingam, Darshan Devang Divakar, S Saravana Kumar, Annapoorani Manoharan","doi":"10.1007/s44445-025-00104-0","DOIUrl":"10.1007/s44445-025-00104-0","url":null,"abstract":"<p><p>Bone mineral density (BMD) is a critical indicator of skeletal health, with implications for systemic conditions such as osteoporosis and localized oral diseases. Dental radiographs, routinely employed in clinical practice, offer a non-invasive means to assess bone quality, yet their role in quantifying BMD and diagnosing metabolic bone disorders remains underexplored. This systematic review of literature examines the diagnostic efficacy of dental radiographs in evaluating BMD. A comprehensive analysis of existing studies in databases such as PubMed, Scopus, Web of Science, ScienceDirect, and SpringerLink was conducted to identify patterns, methodologies, and gaps in the current understanding of radiographic bone assessment for early detection of osteoporosis. The search covered studies published between January 2001 and August 2025, utilizing a search string including \"Dental Radiographs\" [Mesh] OR \"Panoramic Radiography\" [Mesh] OR \"Periapical Radiography\" OR \"Cone-Beam Computed Tomography\" [Mesh])AND (\"Bone Mineral Density\" [Mesh] OR \"Osteoporosis\" [Mesh]) AND (\"DXA\" OR \"Dual-Energy X-ray Absorptiometry\" [Mesh]) AND (\"Correlation\" OR \"Assessment\" OR \"Evaluation\"). Database searching yielded 1,247 records relevant to the study objective. After duplicate removal and meticulous screening, 17 studies met the inclusion criteria and were included in the review. The findings of the reviewed studies indicate that dental radiographs, particularly panoramic and periapical imaging, show moderate correlation with dual-energy X-ray absorptiometry (DXA) in detecting osteoporosis. However, precision varies with imaging technique and anatomical region. Quantitative analyses of trabecular patterns and cortical thickness further suggest that dental radiographs can serve as supplementary tools for early BMD screening, especially in high-risk populations. However, inconsistencies in diagnostic thresholds and limited standardization across studies highlight the need for further research. This review underscores the potential of dental radiographs as accessible screening tools, while emphasizing the need to refine analytical protocols to enhance their reliability in clinical and research settings.</p>","PeriodicalId":47246,"journal":{"name":"Saudi Dental Journal","volume":"38 1","pages":"5"},"PeriodicalIF":2.3,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12799815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145960449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-08DOI: 10.1007/s44445-025-00102-2
Hanna Ficoń, Szymon Zniszczoł, Tadeusz Morawiec, Bogusława Orzechowska-Wylęgała, Agnieszka Balicz
Corneal blindness remains a significant challenge in modern ophthalmology, accounting for 12% of global blindness cases. While corneal transplantation is often an effective treatment, its success is limited in patients with severe ocular surface diseases such as Stevens-Johnson syndrome, trachoma, or autoimmune-related dry eye disease. For these patients, osteo-odonto-keratoprosthesis (OOKP) has emerged as a highly specialized surgical solution, utilizing a patient's tooth as a scaffold for an artificial cornea, providing long-term visual restoration. This article traces the historical evolution of keratoprostheses, beginning with early 19th-century attempts at artificial cornea implantation to the modern Rome-Vienna protocol of OOKP. The surgical procedure is outlined from both ophthalmological and surgical perspectives, detailing key modifications, such as complete removal of the iris and lens, use of custom-made optical cylinders, and advanced biocompatible materials. These improvements have significantly enhanced the stability and longevity of the procedure while reducing the risk of complications such as glaucoma, inflammation, and implant rejection. A systematic review of scientific literature was conducted, analyzing 39 sources primarily obtained from PubMed. Researchers carefully selected these articles based on their abstracts to ensure relevance, providing a comprehensive analysis of OOKP.This article highlights its role as an advanced alternative for treating end-stage corneal blindness, offering hope to patients who are not candidates for conventional corneal transplantation. Osteo-odonto-keratoprosthesis (OOKP) is an innovative method for restoring vision in patients with severe corneal damage, significantly improving their quality of life. While the procedure presents challenges and risks, many individuals who undergo OOKP regain the ability to see and regain independence. Technological advancements should focus on refining the technique, minimizing complications, and increasing its accessibility. Additionally, patient education and support are crucial for successful rehabilitation and adaptation. OOKP is a remarkable achievement in medicine and biomedical engineering, offering hope to patients and inspiring further research to enhance the quality of life for people worldwide.
{"title":"Osteo-odonto-keratoprosthesis: a surgical procedure for treating advanced corneal diseases.","authors":"Hanna Ficoń, Szymon Zniszczoł, Tadeusz Morawiec, Bogusława Orzechowska-Wylęgała, Agnieszka Balicz","doi":"10.1007/s44445-025-00102-2","DOIUrl":"10.1007/s44445-025-00102-2","url":null,"abstract":"<p><p>Corneal blindness remains a significant challenge in modern ophthalmology, accounting for 12% of global blindness cases. While corneal transplantation is often an effective treatment, its success is limited in patients with severe ocular surface diseases such as Stevens-Johnson syndrome, trachoma, or autoimmune-related dry eye disease. For these patients, osteo-odonto-keratoprosthesis (OOKP) has emerged as a highly specialized surgical solution, utilizing a patient's tooth as a scaffold for an artificial cornea, providing long-term visual restoration. This article traces the historical evolution of keratoprostheses, beginning with early 19th-century attempts at artificial cornea implantation to the modern Rome-Vienna protocol of OOKP. The surgical procedure is outlined from both ophthalmological and surgical perspectives, detailing key modifications, such as complete removal of the iris and lens, use of custom-made optical cylinders, and advanced biocompatible materials. These improvements have significantly enhanced the stability and longevity of the procedure while reducing the risk of complications such as glaucoma, inflammation, and implant rejection. A systematic review of scientific literature was conducted, analyzing 39 sources primarily obtained from PubMed. Researchers carefully selected these articles based on their abstracts to ensure relevance, providing a comprehensive analysis of OOKP.This article highlights its role as an advanced alternative for treating end-stage corneal blindness, offering hope to patients who are not candidates for conventional corneal transplantation. Osteo-odonto-keratoprosthesis (OOKP) is an innovative method for restoring vision in patients with severe corneal damage, significantly improving their quality of life. While the procedure presents challenges and risks, many individuals who undergo OOKP regain the ability to see and regain independence. Technological advancements should focus on refining the technique, minimizing complications, and increasing its accessibility. Additionally, patient education and support are crucial for successful rehabilitation and adaptation. OOKP is a remarkable achievement in medicine and biomedical engineering, offering hope to patients and inspiring further research to enhance the quality of life for people worldwide.</p>","PeriodicalId":47246,"journal":{"name":"Saudi Dental Journal","volume":"38 1","pages":"4"},"PeriodicalIF":2.3,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12779821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}