Skeletal Editing of Isatins for Heterocycle Molecular Diversity

IF 7 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Chemical record Pub Date : 2024-06-07 DOI:10.1002/tcr.202400024
Tiantian Zhang, Prof. Huangdi Feng
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Abstract

Isatins have been widely used in the preparation of a variety of heterocyclic compounds, where the skeletal editing of isatins has shown significant advantages for the construction of diverse heterocycles. This review highlights the progress made in the last decade (2013−2023) in the skeletal editing of the isatin scaffold. A series of ring expansion reactions for the construction of quinoline skeleton, quinolone skeleton, polycyclic quinazoline skeleton, medium-sized ring skeleton, as well as a series of ring opening reactions for the generation of 2-(azoly)aniline skeleton by the cleavage of C−C bond and C−N bond are highlighted. It is hoped that this review will provide some understanding of the chemical transformations of isatins and contribute to the further realization of its molecular diversity.

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对异形蛋白进行骨架编辑以实现杂环分子多样性。
异汀类化合物被广泛用于制备各种杂环化合物,其中异汀类化合物的骨架编辑在构建各种杂环化合物方面具有显著优势。本综述重点介绍了过去十年(2013-2023 年)在异atin 支架骨架编辑方面取得的进展。重点介绍了构建喹啉骨架、喹诺酮骨架、多环喹唑啉骨架、中型环骨架的一系列扩环反应,以及通过裂解 C-C 键和 C-N 键生成 2-(偶氮)苯胺骨架的一系列开环反应。希望这篇综述能让人们对异汀类化合物的化学转化有一定的了解,并有助于进一步认识其分子的多样性。
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来源期刊
Chemical record
Chemical record 化学-化学综合
CiteScore
11.00
自引率
3.00%
发文量
188
审稿时长
>12 weeks
期刊介绍: The Chemical Record (TCR) is a "highlights" journal publishing timely and critical overviews of new developments at the cutting edge of chemistry of interest to a wide audience of chemists (2013 journal impact factor: 5.577). The scope of published reviews includes all areas related to physical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, polymer chemistry, materials chemistry, bioorganic chemistry, biochemistry, biotechnology and medicinal chemistry as well as interdisciplinary fields. TCR provides carefully selected highlight papers by leading researchers that introduce the author''s own experimental and theoretical results in a framework designed to establish perspectives with earlier and contemporary work and provide a critical review of the present state of the subject. The articles are intended to present concise evaluations of current trends in chemistry research to help chemists gain useful insights into fields outside their specialization and provide experts with summaries of recent key developments.
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