Establishment of Reference Range for Serum Concentration of Vitamin A and Vitamin E in Southern Sichuan Area of China

IF 2.6 4区医学 Q2 MEDICAL LABORATORY TECHNOLOGY Journal of Clinical Laboratory Analysis Pub Date : 2024-06-07 DOI:10.1002/jcla.25074

Qiang Ye, Qiang Zhong, Guoping Huang, Wen Zhang

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Abstract

Objective

To establish the reference range of serum concentration of vitamin A (VA) and vitamin E (VE) in Southern Sichuan area of China.

Methods

From August 1, 2021, to May 31, 2023, 9482 blood tablets were received for the screening of VA and VE. The information was divided into four different age groups: ≤1 year old, 1< to ≤6 years, 6< to ≤17 years, and 17< to ≤59 years. In each age group, the four seasons were further subdivided into spring, summer, autumn, and winter, as well as male and female genders. The serum concentration of VA and VE was detected by liquid chromatography—tandem mass spectrometry (HPLC-MS), and the reference range was established for verification.

Results

The concentration of VA and VE in 9482 cases showed skewed distribution. When comparing between different age groups, the serum concentration of VA and VE was statistically significant (p < 0.05). While comparing different seasons, the serum VA levels in different seasons were significantly different (p < 0.05) except in summer and autumn. There was statistical significance in VE level in different seasons (p < 0.05). And while comparing different genders, there was no statistical significance in VA concentration levels (p > 0.05). The VE concentration levels were statistically significant (p < 0.05). The established reference range was established and verified, and the results were in accordance with the standard.

Conclusion

The reference range of VA and VE should be set according to different ages, different seasons, and different genders.

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中国四川南部地区血清中维生素 A 和维生素 E 浓度参考范围的确定。

目的方法：从 2021 年 8 月 1 日至 2023 年 5 月 31 日，在四川南部地区开展血清维生素 A（VA）和维生素 E（VE）浓度的参考范围测定：方法：自 2021 年 8 月 1 日至 2023 年 5 月 31 日，共采集 9482 份血片用于维生素 A 和维生素 E 的筛查。资料分为四个不同年龄组：≤1 岁、1＜～≤6 岁、6＜～≤17 岁、17＜～≤59 岁。每个年龄组又细分为春、夏、秋、冬四个季节和男女性别。采用液相色谱-串联质谱法（HPLC-MS）检测血清中VA和VE的浓度，并建立参考范围进行验证：结果：9482 个病例的 VA 和 VE 浓度呈偏态分布。不同年龄组血清中 VA 和 VE 浓度比较，差异有统计学意义（P 0.05）。VE 浓度水平也有统计学意义（P 结论：VA 和 VE 的参考值范围为 0.05%：应根据不同年龄、不同季节和不同性别设定 VA 和 VE 的参考范围。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Laboratory Analysis 医学-医学实验技术

CiteScore

5.60

自引率

7.40%

发文量

584

审稿时长

6-12 weeks

期刊介绍： Journal of Clinical Laboratory Analysis publishes original articles on newly developing modes of technology and laboratory assays, with emphasis on their application in current and future clinical laboratory testing. This includes reports from the following fields: immunochemistry and toxicology, hematology and hematopathology, immunopathology, molecular diagnostics, microbiology, genetic testing, immunohematology, and clinical chemistry.