Willingness to experience unpleasant thoughts, emotions, and bodily sensations at admission does not predict treatment outcome in inpatients with obsessive-compulsive disorder.

Eva M Zisler, Adrian Meule, Stefan Koch, Ulrich Voderholzer
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Abstract

Background: Some persons with obsessive-compulsive disorder (OCD) refuse or drop out of treatment because of the aversive nature of exposure and response prevention therapy when they have to face and tolerate unpleasant thoughts, emotions, and bodily sensations. Indeed, one study suggested that a higher willingness to experience unpleasant thoughts, emotions, and bodily sensations (WTE) predicts a better treatment outcome, but this finding has not been replicated yet.

Methods: We examined whether WTE at admission predicted treatment outcome in a sample of 324 inpatients with OCD who received a multimodal treatment that included cognitive-behavioral therapy with exposure and response prevention sessions.

Results: Obsessive-compulsive symptoms (based on OCD-specific self-report questionnaires) decreased with medium-to-large effect sizes (all ps < 0.001) and global functioning (based on therapist ratings) increased with a large effect size (d = 1.3, p < 0.001) from admission to discharge. In contrast to previous findings, however, WTE did not predict treatment outcome (all ps > 0.005). The effect of WTE on treatment outcome remained non-significant when controlling for any comorbidity, age, sex, length of stay, and antidepressant medication and was not moderated by these variables.

Conclusions: Results indicate that higher WTE at the beginning of inpatient treatment does not facilitate improvements in obsessive-compulsive symptoms from admission to discharge. However, they also indicate that lower WTE at the beginning of inpatient treatment does not adversely affect treatment outcome, that is, even patients who indicate that they are unwilling to face the negative experiences associated with exposure and response prevention can still achieve considerable symptom reductions.

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入院时是否愿意体验不愉快的想法、情绪和身体感觉并不能预测强迫症住院患者的治疗效果。
背景:一些强迫症(OCD)患者拒绝或放弃治疗,原因是暴露和反应预防疗法会让他们不得不面对和忍受不愉快的想法、情绪和身体感觉。事实上,一项研究表明,更愿意体验不愉快的想法、情绪和身体感觉(WTE)预示着更好的治疗结果,但这一发现尚未得到证实:我们对 324 名住院强迫症患者进行了抽样调查,这些患者接受了包括认知行为疗法、暴露和反应预防课程在内的多模式治疗,我们研究了入院时的 WTE 是否预示着治疗结果:强迫症症状(基于强迫症特异性自我报告问卷)有所减轻,其效应大小为中度到大型(所有 ps 均为 0.005)。在控制了任何合并症、年龄、性别、住院时间和抗抑郁药物治疗后,WTE对治疗结果的影响仍然不显著,并且不受这些变量的调节:结论:研究结果表明,住院治疗开始时较高的 WTE 并不能促进入院至出院期间强迫症状的改善。然而,结果也表明,住院治疗初期较低的WTE并不会对治疗结果产生不利影响,也就是说,即使患者表示不愿意面对与暴露和反应预防相关的负面体验,他们的症状仍然可以得到显著缓解。
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