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Distribution and association of road traffic accident with depression among Indian population aged 45 years and above: nested multilevel modelling analysis of nationally representative cross-sectional survey. 印度 45 岁及以上人口中道路交通事故与抑郁症的分布和关联:对全国代表性横断面调查的嵌套多层次建模分析。
Pub Date : 2024-11-28 DOI: 10.1007/s44192-024-00118-w
Pritam Halder, Sayan Saha, Anshul Mamgai, Abhinav Chandra Sekhar Kolachala, Ankita Chattopadhyay, Shivani Rathor, Manish Chandra Prabhakar

Introduction: The prevalence of important public health problems like road traffic accidents (RTA) and depression are surging. This study was aimed to estimate distribution and determine the association between RTA and depression among Indian population aged 45 years and above: overall and stratified into age group, gender and across states/union territories as aspirants, achievers, and front runners.

Methods: Using Longitudinal Aging Study in India (LASI) dataset (April 2017-December 2018), we have conducted this study among middle aged (45-59 years) and older adults and elderly (≥ 60 years) Indians. Bivariate analysis was conducted to estimate the prevalence of RTA and depression nationally and across aspirants, achievers, and front runner states. States and union territories were categorised as low, medium, and high as per RTA and depression prevalence, which were further cross tabulated. Spatial distribution maps were created using Microsoft Excel. We have documented the association of RTA with depression. To reduce the confounding effects of demographic and socioeconomic; health related and behavioural covariates; propensity score matching (PSM) was conducted. Nested multilevel regression modelling was analysed using STATA version 17.

Results: Prevalence of RTA was 1.84% (1.74-1.94) nationally, highest among achiever states [2.04% (1.82-2.30)]. Prevalence of depression was 6.08% (5.90-6.26) nationally, highest among aspirant states [7.02% (6.74-7.30)]. The adjusted odds of having RTA was significantly among depressed [aOR (95% CI) 1.76 (1.45-2.15)] than non-depressed participants; which was much higher among females [aOR (95% CI) 1.93 (1.43-2.62)] than in males [aOR (95%CI) 1.67 (1.29-2.16)] and much higher among middle aged [aOR (95%CI) 2.08 (1.63-2.65)]. Odds of RTA was highest across front runners [aOR (95%CI) 1.86 (1.26-2.72)] followed by aspirant states [aOR (95%CI) 1.79 (1.37-2.33)].

Conclusion: This study established the positive association between depression and road traffic accidents among middle aged, older adults and elderly. Therefore, efforts must be taken to address mental health issues in them with proper policy implication more focused on females and middle aged. Front runner's states should get the limelight followed by aspirant states.

导言:道路交通事故(RTA)和抑郁症等重要公共健康问题的发病率正在急剧上升。本研究旨在估算印度 45 岁及以上人口中道路交通事故和抑郁症的分布情况,并确定两者之间的关联:总体情况,并按年龄组、性别以及各邦/中央直辖区的有志者、有为者和领先者进行分层:利用印度纵向老龄化研究(LASI)数据集(2017 年 4 月至 2018 年 12 月),我们在中老年人(45-59 岁)和老年人(≥ 60 岁)中开展了这项研究。我们进行了双变量分析,以估算全国以及有抱负者、有成就者和领跑者各邦的 RTA 和抑郁症患病率。根据 RTA 和抑郁症患病率,将各邦和中央直辖区分为低、中、高三类,并进一步交叉列表。使用 Microsoft Excel 绘制了空间分布图。我们记录了 RTA 与抑郁症的关系。为了减少人口、社会经济、健康相关因素和行为协变量的混杂效应,我们进行了倾向得分匹配(PSM)。使用 STATA 17 版本对嵌套多层次回归模型进行了分析:全国 RTA 患病率为 1.84% (1.74-1.94),在成绩优异的州中最高[2.04% (1.82-2.30)]。全国抑郁症患病率为 6.08%(5.90-6.26),在有抱负的州中最高[7.02%(6.74-7.30)]。抑郁症患者的调整后 RTA 发生几率[aOR (95%CI) 1.76 (1.45-2.15)]明显高于非抑郁症患者;女性患者的调整后 RTA 发生几率[aOR (95%CI) 1.93 (1.43-2.62)]远高于男性患者[aOR (95%CI) 1.67 (1.29-2.16)],中年患者的调整后 RTA 发生几率[aOR (95%CI) 2.08 (1.63-2.65)]也远高于非抑郁症患者。RTA的几率在前跑者中最高[aOR (95%CI) 1.86 (1.26-2.72)],其次是有志者[aOR (95%CI) 1.79 (1.37-2.33)]:本研究确定了抑郁症与中老年人道路交通事故之间的正相关关系。因此,必须努力解决他们的心理健康问题,并制定适当的政策,重点关注女性和中老年人。领先的州应成为关注的焦点,有抱负的州应紧随其后。
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引用次数: 0
Unveiling the burden: prevalence and predictors of psychological distress among domestic workers in Kigali-Rwanda. 揭示负担:基加利-卢旺达家庭佣工心理困扰的普遍性和预测因素。
Pub Date : 2024-11-25 DOI: 10.1007/s44192-024-00112-2
Alain Favina, Everest Turatsinze, Dan Lutasingwa, Joan Abaatyo, Fred Mulisa, Ritah Mukashyaka, Deborah Kansiime, Nicholas Hobe, Octave Ngabo, Jean Marie Vianney Rukanikigitero, Moses Ochora, Louange Twahirwa Gutabarwa, Precious Azubuike, Aflodis Kagaba, Mark Mohan Kaggwa

Background: Psychological distress is becoming more prominent among employees in various workplaces, and domestic work may not be an exception. This study aimed to determine the prevalence of psychological distress and associated factors among domestic workers in Rwanda.

Methods: This cross-sectional study captured data from 870 domestic workers in Kigali City, Rwanda. Psychological distress was measured using questions from the Kessler Psychological Distress Scale (K10). Binary Logistic regression analyses were used to ascertain the factors associated with psychological distress.

Results: The prevalence of psychological distress was 50.1%. The likelihood of having psychological distress was higher among females, those using substances of abuse, those having over four dependents in the household, and those having worked as domestic workers longer.

Conclusion: Half of the domestic workers in Kigali-Rwanda experience distress. To mitigate this burden, awareness of psychological distress among domestic workers and improvement of services to mitigate psychological distress should be increased. These services should particularly target those who are female, with more dependents, who have worked longer in the profession, and who use substances of addiction.

背景:心理困扰在各种工作场所的员工中日益突出,家政工作可能也不例外。本研究旨在确定卢旺达家庭佣工的心理困扰发生率及相关因素:这项横断面研究收集了卢旺达基加利市 870 名家庭佣工的数据。心理困扰采用凯斯勒心理困扰量表(K10)中的问题进行测量。研究采用二元逻辑回归分析来确定与心理困扰相关的因素:结果:心理困扰的发生率为 50.1%。女性、使用滥用药物者、家中有四名以上受抚养人者和从事家政工作时间较长者出现心理困扰的可能性较高:结论:基加利-卢旺达一半的家庭佣工都有心理困扰。为减轻这一负担,应提高对家庭佣工心理压力的认识,并改善减轻心理压力的服务。这些服务应特别针对那些女性、受抚养人较多、从事家政工作时间较长以及使用成瘾物质的家政人员。
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引用次数: 0
Patterns and outcomes of individuals admitted at emergency units following intentional self-harm in Northern Uganda. 乌干达北部因故意自我伤害而入住急诊室的人员的模式和结果。
Pub Date : 2024-11-25 DOI: 10.1007/s44192-024-00115-z
Mark Mohan Kaggwa, Joan Abaatyo, Keneth Opiro, Margret Sikoti, Felix Bongomin

We retrospectively reviewed charts of 253 self-harming patients admitted to emergency units in Northern Uganda in 2021. Twenty-two (8.7%) died by suicide, especially due to organophosphate poisoning (n = 14, 63.6%). Regarding self-harm management, observed differences were noted in the type of hospital and the use of antidotes between public and private facilities. There is a need for more studies and a multisector approach to prevent and treat self-harm in Uganda.

我们回顾性地查看了2021年乌干达北部急诊室收治的253名自我伤害患者的病历。22人(8.7%)死于自杀,尤其是有机磷中毒(14人,63.6%)。在自残处理方面,我们注意到公立和私立医院在医院类型和解毒剂使用方面存在差异。乌干达需要更多的研究和多部门方法来预防和治疗自残。
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引用次数: 0
The role of emotion regulation strategies as the mediator between self-compassion and depression among undergraduates in Yunnan province, China. 情绪调节策略在中国云南省大学生自我同情与抑郁之间的中介作用。
Pub Date : 2024-11-14 DOI: 10.1007/s44192-024-00114-0
Yu Peng, Zahari Ishak

Self-compassion (SC) and its influence on mental health have always been a significant focus in psychological research, especially given the alarming prevalence of depression among Chinese university students. The purpose of this study is to examine the relationship between SC, encompassing both self-warmth and self-coldness, and depression among Chinese undergraduates, with emotion regulation strategies (ERS) serving as a mediator. The sample comprised 21,353 undergraduates from Yunnan Province, China, with data collected at two time points (T1 and T2). SC was measured using the Self-Compassion Scale-Short Form (SCS-SF), while depression was assessed with the Beck Depression Inventory (BDI). ERS were measured using the Cognitive Emotion Regulation Questionnaire-short (CERQ-short). Data were analyzed using structural equation modeling. Results demonstrated that the model of self-warmth, self-coldness, ERS, and depression fit the data well. Upon controlling for depression at T1, both self-warmth and self-coldness were significant predictors of depression through ERS. ERS were found to be a significant mediator in this study. The results indicated that self-warmth enhances adaptive ERS and reduces maladaptive ERS, leading to lower levels of depression, while self-coldness has the opposite influence.

自我同情(SC)及其对心理健康的影响一直是心理学研究的一个重要焦点,尤其是考虑到中国大学生抑郁症的发病率令人担忧。本研究的目的是以情绪调节策略(ERS)为中介,探讨自我同情(包括自我温暖和自我冷漠)与中国大学生抑郁之间的关系。样本由中国云南省的 21353 名大学生组成,在两个时间点(T1 和 T2)收集数据。SC采用自怜量表-简表(SCS-SF)进行测量,抑郁采用贝克抑郁量表(BDI)进行评估。ERS采用认知情绪调节问卷-简表(CERQ-short)进行测量。数据采用结构方程模型进行分析。结果表明,由自我温暖、自我冷漠、ERS 和抑郁组成的模型很好地拟合了数据。在控制了第一阶段的抑郁情绪后,自我温暖度和自我冷感都能通过 ERS 显著预测抑郁情绪。在本研究中,ERS 被认为是一个重要的中介因素。结果表明,自我温暖增强了适应性ERS,减少了不良适应性ERS,从而导致抑郁水平降低,而自我冷漠则具有相反的影响。
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引用次数: 0
Prevalence of substance use among a sample of patients attending an outpatient psychiatric clinic in Amman, Jordan. 约旦安曼精神病门诊病人使用药物的普遍程度。
Pub Date : 2024-11-14 DOI: 10.1007/s44192-024-00113-1
Layali N Abbasi, Tewfik K Daradkeh, Mohamed ElWasify, Sanad Abassy

Background: The issue of substance use is increasingly being recognised as a significant global public health concern. In relation to its influence in the Arab world, scholarly investigation continues to be regarded as relatively constrained in scope. We aimed to investigate the prevalence of substance use among patients with psychiatric disorders, as well as the sociodemographic and clinical characteristics of this patient population. This cross-sectional study included 671 patients with psychiatric disorders who attended an outpatient private psychiatric clinic in Amman, Jordan, between January and May 2023. We compared the demographic and clinical characteristics of substance-using and non-substance-using patients. Bivariate and multiple binary logistic regression analyses were used to investigate factors associated with substance use.

Results: The patients were aged 20-80 years, with a mean age of 32.45 ± 10.18 years. Most patients were men, more than half were single and unemployed, and mood disorders were the most prevalent psychiatric disorder. Male sex, a younger age, lower educational attainment, current unemployment, and having a family history of substance use were associated with substance use. Substance users exhibited a higher propensity for engaging in self-harming behaviours, having medical conditions, and being subjected to emotional trauma.

Conclusions: This study found that patients with psychiatric disorders are vulnerable to experiencing substance use. Clinicians should contemplate directing their attention towards patients as a strategy to proactively address the issue of emerging substance use and enhance overall treatment outcomes.

背景:人们日益认识到,药物使用问题是一个重大的全球公共卫生问题。就其在阿拉伯世界的影响而言,学术调查的范围仍然相对有限。我们的目的是调查精神障碍患者使用药物的普遍程度,以及这一患者群体的社会人口学和临床特征。这项横断面研究纳入了 671 名精神病患者,他们于 2023 年 1 月至 5 月期间在约旦安曼的一家私人精神病门诊就诊。我们比较了药物滥用患者和非药物滥用患者的人口统计学特征和临床特征。我们使用二元和多元二元逻辑回归分析来研究与药物使用相关的因素:患者年龄在 20-80 岁之间,平均年龄为(32.45 ± 10.18)岁。大多数患者为男性,半数以上为单身和失业,情绪障碍是最常见的精神疾病。男性性别、年龄较小、教育程度较低、目前失业以及有药物使用家族史与药物使用有关。药物使用者有较高的自我伤害行为倾向、患有疾病和遭受精神创伤:本研究发现,精神障碍患者很容易使用药物。临床医生应考虑将对患者的关注作为一种策略,积极解决新出现的药物使用问题,并提高整体治疗效果。
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引用次数: 0
Physical activity, leisure-time management, perceived barriers to physical activity and mental well-being among Turkish university students. 土耳其大学生的体育活动、闲暇时间管理、体育活动障碍感知和心理健康。
Pub Date : 2024-11-12 DOI: 10.1007/s44192-024-00109-x
Yunus Emre Kundakcı, Sultan Karaman, Medine Sıla Ateş

This study examined the relationship between physical activity (PA) level, free time management, mental well-being, and perceptions of barriers to PA among university students. A cross-sectional survey was conducted with 723 Turkish university students, which included four questionnaires to assess participants' PA levels, conditions of mental well-being, free time management, and perceived barriers to PA. Multivariate linear regression was performed to identify factors associated with the participants' PA level. The study found that 216 (29.9%) of participants were inactive, 325 (45%) were minimally active, and 182 (25.1%) were health-enhancing active. While 25.23% of males were inactive, 42.02% were minimally active, and 31.45% were health-enhancing active, these rates were 31.4, 45.98, and 22.62% for females, respectively. These findings highlight that 3/4 of university students have inadequate PA levels. Changes in barriers to PA (p < 0.001), free time management (p = 0.040), and mental well-being (p < 0.001) were associated with PA levels. According to the regression analysis, only increased barriers to PA was a significant predictor of PA (p < 0.001). Given the role of health science students in public health, this study could help policymakers develop new strategies to promote healthy living and address barriers to PA, such as students' free time and mental health.

本研究探讨了大学生的体育锻炼(PA)水平、自由时间管理、心理健康以及对体育锻炼障碍的看法之间的关系。该研究对 723 名土耳其大学生进行了横断面调查,其中包括四份问卷,用于评估参与者的体育锻炼水平、精神健康状况、自由时间管理以及对体育锻炼障碍的认知。研究还进行了多元线性回归,以确定与参与者 PA 水平相关的因素。研究发现,216 名参与者(29.9%)不积极参加体育锻炼,325 名参与者(45%)很少参加体育锻炼,182 名参与者(25.1%)参加了增强健康的体育锻炼。其中,25.23%的男性不运动,42.02%的男性很少运动,31.45%的男性运动有益健康,而女性的这一比例分别为 31.4%、45.98% 和 22.62%。这些调查结果表明,3/4 的大学生运动量不足。锻炼障碍的变化(p
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引用次数: 0
Shedding light on maternal mental health in LMICs: a cornerstone of maternal and child health care. 揭示低收入和中等收入国家的孕产妇心理健康问题:孕产妇和儿童保健的基石。
Pub Date : 2024-11-12 DOI: 10.1007/s44192-024-00111-3
Alisha Handa, Abhay Gaidhane, Sonali Choudhari

Maternal and Child Health (MCH) programs have long been integral to global public health initiatives, aiming to safeguard the well-being of both mothers and their offspring. However, amidst the comprehensive approach to physical health, the mental well-being of mothers has often been overlooked, representing a critical gap in these programs. This paper examines the importance of addressing maternal mental health within the framework of MCH programs, highlighting its significance and the repercussions of its neglect. Despite its profound impact on maternal and child outcomes, issues such as postpartum depression, anxiety, and maternal stress are frequently disregarded in MCH interventions. This oversight not only undermines the holistic nature of maternal health but also perpetuates cycles of poor mental health within families and communities. Herewith, an effort was made to highlight the importance of maternal mental health and the need to focus and strengthen awareness about it through policy and programs.

长期以来,母婴健康(MCH)计划一直是全球公共卫生行动不可或缺的一部分,旨在保障母亲及其后代的福祉。然而,在全面关注身体健康的同时,母亲的心理健康却常常被忽视,成为这些计划中的一个重要缺口。本文探讨了在母婴保健计划框架内解决孕产妇心理健康问题的重要性,强调了其重要性以及忽视它所带来的影响。尽管产后抑郁、焦虑和产妇压力等问题对母婴结果有着深远的影响,但在母婴保健干预中却经常被忽视。这种疏忽不仅破坏了孕产妇健康的整体性,也使家庭和社区内不良的心理健康循环长期存在。在此,我们努力强调孕产妇心理健康的重要性,以及通过政策和计划关注和加强孕产妇心理健康意识的必要性。
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引用次数: 0
Gym and swim: a co-facilitated exercise program that improves community connection, confidence, and exercise habits in a community mental health service. 健身房和游泳:一项共同促进的锻炼计划,在社区心理健康服务中改善了社区联系、自信心和锻炼习惯。
Pub Date : 2024-11-11 DOI: 10.1007/s44192-024-00110-4
Sophie Forlico, Andrew Baillie, Kate Keys, Peter Woollett, Georgia Frydman, Andrew Simpson

High rates of cardiometabolic disease and poor physical health outcomes contribute to significant premature mortality in people living with severe mental illness (PLWSMI). Lifestyle interventions such as exercise are known to improve both physical and mental health outcomes, however the best way to deliver exercise programs for PLWSMI remains a challenge. This paper uses a pragmatic program evaluation of a co-delivered low-cost community-based exercise program implemented over a 6-month period. Of 46 referrals in the first half of 2023 to the SLHD Gym and Swim program, 13 gave consent to participate in standardised measures and qualitative interviews. Findings revealed an increase in average hours of sport/exercise, improvements in confidence to exercise independently and within group settings, as well as achievement of individualised goals. The success of the program was in part due to the co-facilitation between peer support workers and exercise physiologists, community connection and the established partnership between the public health service and the local government council. Results offer evidence to adopt and implement accessible and low-cost exercise opportunities in the community external to health services to address barriers of attendance for PLWSMI.

严重精神疾病患者(PLWSMI)的心血管代谢疾病发病率高、身体健康状况不佳,是导致他们过早死亡的重要原因。众所周知,运动等生活方式干预措施可改善身心健康状况,但如何为重症精神病患者提供最佳的运动计划仍是一项挑战。本文采用务实的项目评估方法,对为期 6 个月的共同交付低成本社区运动项目进行了评估。2023 年上半年,SLHD "健身与游泳 "项目转介了 46 人,其中 13 人同意参加标准化测量和定性访谈。调查结果显示,运动/锻炼的平均时数增加了,独立锻炼和集体锻炼的信心增强了,个性化目标也实现了。该计划的成功部分归功于同伴支持工作者和运动生理学家的共同促进、社区联系以及公共卫生服务机构和地方政府委员会之间建立的合作关系。研究结果为在医疗服务机构以外的社区采用和实施方便、低成本的运动机会提供了证据,以解决 PLWSMI 的就医障碍。
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引用次数: 0
Psychiatric disorders endorsed by trauma-exposed premenopausal women enrolled in a cardiovascular research study: a 2-year report. 参加心血管研究的绝经前妇女在遭受创伤后出现的精神障碍:一份为期两年的报告。
Pub Date : 2024-11-08 DOI: 10.1007/s44192-024-00108-y
Chowdhury Tasnova Tahsin, Zynab Ahmed, Azhaar Mohamed, Chowdhury Ibtida Tahmin, Redeat Wattero, Chasity Corbin, Ida T Fonkoue

Introduction: Women are more likely than men to experience interpersonal trauma, with 1 in 3 women affected globally. This paper aims to give a 2-year report of the demographics, trauma history [i.e., non-interpersonal and interpersonal including adverse childhood event (ACEs)] and psychiatric disorders endorsed by premenopausal women screened for our cardiovascular research study.

Methods: Premenopausal women were recruited from the Twin-Cities area using flyers. Interested participants were screened for this study via REDCap. Age, race, history of psychiatric disorders, menopausal status, contraceptives, and current medications were collected. Participants who met the eligibility criteria were enrolled and completed additional questionnaires focusing on trauma exposure and mental health.

Results: The first 2 years our study was open to accrual, a total of 447 premenopausal women were screened. The majority (~ 71%) of our participants were between 18 and 30 years old. Among the 447 women, 35% reported a diagnosis of posttraumatic stress disorder (PTSD), while 46% reported depression and 53% an anxiety disorder, according to DSM-5. Further, we found that women between the ages of 21-25 years reported the most (23%) psychiatric disorders, mainly PTSD. The main type of trauma reported was interpersonal trauma (~ 62%), of which 76% were ACEs.

Conclusion: Among the trauma-exposed women enrolled in our study, the age group between 21 and 25 years old endorsed the most psychiatric disorders, possibly stemming from ACEs. Our findings shed the light on the rising rate of psychiatric disorders in premenopausal women and support the growing public health burden of trauma exposure, particularly in childhood.

简介与男性相比,女性更容易遭受人际创伤,全球每 3 名女性中就有 1 人受到影响。本文旨在对我们的心血管研究筛选出的绝经前妇女的人口统计学、创伤史(即非人际创伤和人际创伤,包括不良童年事件(ACE))和精神障碍进行为期两年的报告:通过传单从双子城地区招募绝经前妇女。通过 REDCap 对感兴趣的参与者进行筛选。收集了年龄、种族、精神病史、更年期状况、避孕药具和目前服用的药物。符合资格标准的参与者被纳入研究,并填写了以创伤暴露和心理健康为重点的附加问卷:在我们的研究开放的头两年,共有 447 名绝经前妇女接受了筛查。大多数参与者(约占 71%)的年龄在 18-30 岁之间。根据 DSM-5,在 447 名女性中,35% 的人被诊断患有创伤后应激障碍(PTSD),46% 的人被诊断患有抑郁症,53% 的人被诊断患有焦虑症。此外,我们还发现 21-25 岁的女性报告的精神障碍最多(23%),主要是创伤后应激障碍。报告的主要创伤类型为人际创伤(约占 62%),其中 76% 为 ACE:结论:在我们的研究中,21 至 25 岁年龄组的受创伤妇女患精神障碍的比例最高,这可能与 ACE 有关。我们的研究结果揭示了绝经前妇女精神障碍发病率不断上升的趋势,并支持了创伤暴露(尤其是童年时期的创伤暴露)对公共健康造成的日益沉重的负担。
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引用次数: 0
Suicidal behavior in ADHD: the role of comorbidity, psychosocial adversity, personality and genetic factors. 多动症患者的自杀行为:合并症、社会心理逆境、人格和遗传因素的作用。
Pub Date : 2024-11-05 DOI: 10.1007/s44192-024-00103-3
Georg C Ziegler, Silke Groß, Andrea Boreatti, Monika Heine, Rhiannon V McNeill, Thorsten M Kranz, Marcel Romanos, Christian P Jacob, Andreas Reif, Sarah Kittel-Schneider, Klaus-Peter Lesch

Adult ADHD is associated with increased risk for suicide attempts, as indicated by investigations of population- and community-based cohorts. However, there is little data regarding suicide attempts in a clinical setting. To address this, we used a comprehensively phenotyped clinical adult ADHD (aADHD) cohort to assess to which extent comorbidity, psychosocial adversity, personality, and ADHD symptoms contribute to suicidal behavior in ADHD. Furthermore, we investigated a triallelic variation in the serotonin transporter-linked polymorphic region (5-HTTLPR), which has previously been associated with suicidal behavior. Depression, substance use, eating, and posttraumatic stress disorders were independently associated with past suicide attempts, whereas anxiety, somatoform, and obsessive-compulsive spectrum disorders showed no association. Pulmonary diseases also showed an association with suicidal behavior. Psychosocial factors including occupational status, marital status/living situation, externalizing behavior and psychiatric family history were strongly associated with past suicide attempts. ADHD symptoms of inattention and hyperactivity/impulsivity were not associated with past suicide attempts after adjustment for psychiatric comorbidity and psychosocial adversity. However, the personality trait of neuroticism fully mediated the association between depression and suicidal behavior. 5-HTTLPR was not associated with suicidal behavior, but an interaction with ADHD symptoms and subtype was found. Our data suggest that psychiatric comorbidity and psychosocial adversity are key factors for suicidal behavior in aADHD, with neuroticism representing a critical mediator of the association between depression and suicidality. Further research, preferentially with longitudinal study designs is needed to better understand causal factors for suicidal behavior to enable effective preventive action.

对人群和社区队列的调查显示,成人多动症与自杀未遂的风险增加有关。然而,有关在临床环境中企图自杀的数据却很少。为了解决这个问题,我们使用了一个全面表型的临床成人多动症(aADHD)队列,以评估合并症、社会心理逆境、人格和多动症症状在多动症患者中对自杀行为的影响程度。此外,我们还调查了5-羟色胺转运体多态区(5-HTTLPR)的一个试片变异,该变异以前曾与自杀行为有关。抑郁、药物使用、饮食和创伤后应激障碍与以往的自杀企图有独立的关联,而焦虑、躯体形式和强迫谱系障碍则没有关联。肺部疾病也与自杀行为有关。包括职业状况、婚姻状况/生活状况、外化行为和精神病家族史在内的心理社会因素与过去的自杀企图密切相关。注意力不集中和多动/冲动等多动症状在调整了精神病合并症和社会心理逆境之后,与过去的自杀企图无关。然而,神经质这一人格特质完全介导了抑郁与自杀行为之间的关联。5-HTTLPR与自杀行为无关,但与ADHD症状和亚型存在相互作用。我们的数据表明,精神疾病合并症和社会心理逆境是导致多动症患者自杀行为的关键因素,而神经质则是抑郁与自杀之间关联的关键中介因素。为了更好地了解导致自杀行为的因果因素,采取有效的预防措施,我们需要进一步开展研究,最好是采用纵向研究设计。
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引用次数: 0
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