Effect of disease, freezing of gait, and dopaminergic medication in the biomechanics of trunk and upper limbs in the gait of Parkinson's disease

IF 1.6 3区 心理学 Q4 NEUROSCIENCES Human Movement Science Pub Date : 2024-06-07 DOI:10.1016/j.humov.2024.103242
Emanuele Los Angeles , Claudia Eunice Neves de Oliveira , Layla Cupertino , Solaiman Shokur , Mohamed Bouri , Daniel Boari Coelho
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Abstract

Introduction

Parkinson's disease (PD) causes gait abnormalities that may be associated with an arm swing reduction. Medication and freezing of gait (FoG) may influence gait characteristics. However, these comparisons do not consider differences in gait speed and clinical characteristics in individuals with PD.

Objective

This study aims to analyze the effect of FoG and medication on the biomechanics of the trunk and upper limbs during gait in PD, controlling for gait speed and clinical differences between groups.

Methods

Twenty-two people with a clinical diagnosis of idiopathic PD in ON and OFF medication (11 FoG), and 35 healthy participants (control) were selected from two open data sets. All participants walked on the floor on a 10-m-long walkway. The joint and linear kinematic variables of gait were compared: (1) Freezers and nonfreezers in the ON condition and control; (2) Freezers and nonfreezers in the OFF condition and control; (3) Group (freezers and nonfreezers) and medication.

Results

The disease affects the upper limbs more strongly but not the trunk. The medication does not significantly influence the joint characteristics but rather the linear wrist displacement. The FoG does not affect trunk movement and partially influences the upper limbs. The interaction between medications and FoG suggests that the medication causes more substantial improvement in freezers than in nonfreezers.

Conclusion

The study shows differences in the biomechanics of the upper limbs of people with PD, FoG, and the absence of medication. The future rehabilitation protocol should consider this aspect.

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疾病、步态冻结和多巴胺能药物对帕金森病步态中躯干和上肢生物力学的影响
导言帕金森病(PD)会导致步态异常,可能与手臂摆动幅度减小有关。药物治疗和冻结步态(FoG)可能会影响步态特征。本研究旨在分析 FoG 和药物治疗对帕金森病患者步态过程中躯干和上肢生物力学的影响,同时控制步态速度和组间临床差异。方法从两组开放数据中选取了 22 名临床诊断为特发性帕金森病的患者(11 名 FoG 患者)和 35 名健康参与者(对照组)。所有参与者都在 10 米长的走道上行走。对步态的关节和线性运动学变量进行了比较:(1) 开启条件下的冻结者和非冻结者与对照组;(2) 关闭条件下的冻结者和非冻结者与对照组;(3) 组别(冻结者和非冻结者)和药物。药物对关节特征没有明显影响,但对腕关节的线性位移有影响。FoG不影响躯干运动,但对上肢有部分影响。药物和 FoG 之间的相互作用表明,药物对冷冻者的改善比对非冷冻者的改善更明显。未来的康复方案应考虑到这一点。
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来源期刊
Human Movement Science
Human Movement Science 医学-神经科学
CiteScore
3.80
自引率
4.80%
发文量
89
审稿时长
42 days
期刊介绍: Human Movement Science provides a medium for publishing disciplinary and multidisciplinary studies on human movement. It brings together psychological, biomechanical and neurophysiological research on the control, organization and learning of human movement, including the perceptual support of movement. The overarching goal of the journal is to publish articles that help advance theoretical understanding of the control and organization of human movement, as well as changes therein as a function of development, learning and rehabilitation. The nature of the research reported may vary from fundamental theoretical or empirical studies to more applied studies in the fields of, for example, sport, dance and rehabilitation with the proviso that all studies have a distinct theoretical bearing. Also, reviews and meta-studies advancing the understanding of human movement are welcome. These aims and scope imply that purely descriptive studies are not acceptable, while methodological articles are only acceptable if the methodology in question opens up new vistas in understanding the control and organization of human movement. The same holds for articles on exercise physiology, which in general are not supported, unless they speak to the control and organization of human movement. In general, it is required that the theoretical message of articles published in Human Movement Science is, to a certain extent, innovative and not dismissible as just "more of the same."
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