The mediating role of sugar and lipid metabolism and systemic inflammation in the association between breakfast skipping and periodontitis: A population-based study.

IF 4.2 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Journal of periodontology Pub Date : 2024-06-08 DOI:10.1002/JPER.24-0079
Zhikang Wang, Rui Pu, Jing Zhang, Guoli Yang
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Abstract

Background: This study investigated the association between breakfast skipping and periodontitis and the mediating role of sugar and lipid metabolism and systemic inflammation in this association using data from the Korea National Health and Nutrition Examination Survey 2016-2018.

Methods: This study included 11,953 participants, representing an estimated 33.9 million people. Complex sample logistic regression was used to assess the independent association between breakfast skipping and periodontitis. Subgroup analysis was conducted with modifiers including age, sex, body mass index (BMI), urban residence, education level, marital status, and diabetes. Structural equation modeling assessed potential mediation by biomarkers related to glucose and lipid metabolism along with systemic inflammation.

Results: The fully adjusted logistic regression model indicated a positive association between breakfast skipping and periodontitis (odds ratio [OR] = 1.234 (1.026-1.483), p = 0.025). This association was highlighted in middle-aged (40-60 years), female, highly educated, married individuals with BMI < 25 kg/m2, and those in urban areas without diabetes. Blood glucose (β ± SE = 0.006 ± 0.002, p = 0.014), triglycerides (β ± SE = 0.004 ± 0.002, p = 0.033), and white blood cell count (β ± SE = 0.011 ± 0.003, p = 0.003) were identified as partial mediators.

Conclusions: A new, independent association between breakfast skipping, and periodontitis has been discovered, which is partially mediated by sugar and lipid metabolism, and systemic inflammation. The findings provide new insights into the benefits of chrononutrition for periodontal health.

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不吃早餐与牙周炎之间的关系中,糖和脂质代谢及全身炎症的中介作用:一项基于人群的研究。
研究背景本研究利用2016-2018年韩国国民健康与营养调查的数据,调查了不吃早餐与牙周炎之间的关联,以及糖、脂代谢和全身炎症在这一关联中的中介作用:这项研究包括 11953 名参与者,估计代表了 3390 万人。采用复杂样本逻辑回归评估不吃早餐与牙周炎之间的独立关联。对年龄、性别、体重指数(BMI)、城市居住地、教育水平、婚姻状况和糖尿病等修饰因素进行了分组分析。结构方程模型评估了与葡萄糖和脂质代谢以及全身炎症有关的生物标志物的潜在中介作用:完全调整后的逻辑回归模型表明,不吃早餐与牙周炎之间存在正相关(几率比 [OR] = 1.234 (1.026-1.483),P = 0.025)。这种关联在中年(40-60 岁)、女性、受过高等教育、已婚、体重指数(BMI)为 2 和城市地区无糖尿病的人群中尤为突出。血糖(β±SE = 0.006 ± 0.002,p = 0.014)、甘油三酯(β±SE = 0.004 ± 0.002,p = 0.033)和白细胞计数(β±SE = 0.011 ± 0.003,p = 0.003)被认为是部分中介因素:结论:不吃早餐与牙周炎之间发现了一种新的、独立的关联,这种关联部分由糖、脂代谢和全身炎症介导。这些发现为慢性营养对牙周健康的益处提供了新的见解。
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来源期刊
Journal of periodontology
Journal of periodontology 医学-牙科与口腔外科
CiteScore
9.10
自引率
7.00%
发文量
290
审稿时长
3-8 weeks
期刊介绍: The Journal of Periodontology publishes articles relevant to the science and practice of periodontics and related areas.
期刊最新文献
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