Validation of Math Model Using Porous Media for Determining Alveolar CO 2 in Ventilated Patients.

IF 7.7 1区医学 Q1 CRITICAL CARE MEDICINE Critical Care Medicine Pub Date : 2024-10-01 Epub Date: 2024-08-20 DOI:10.1097/CCM.0000000000006350

L D Jiménez-Posada, A F Palacio-Sánchez, Y J Montagut-Ferizzola, M Ardila-Villegas, Juan C Maya

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Abstract

Objectives: To validate a mathematical model using porous media theory for alveolar CO2 determination in ventilated patients.

Design: Mathematical modeling study with prospective clinical validation to simulate CO2 exchange from bloodstream to airway entrance.

Setting: ICU.

Patients: Thirteen critically ill patients without chronic or acute lung disease.

Interventions: None.

Measurements and main results: Model outcomes compared with patient data showed correlations for end-tidal CO2 (EtCO 2 ), area under the CO2 curve, and Pa CO2 of 0.918, 0.954, and 0.995. Determination coefficients ( R2 ) were 0.843, 0.910, and 0.990, indicating precision and predictive power.

Conclusions: The mathematical model shows potential in pulmonary critical care. Although promising, practical application demands further validation, clinician training, and patient-specific adjustments. The path to clinical use will be iterative, involving validation and education.

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验证使用多孔介质测定通气患者肺泡二氧化碳的数学模型

目的：利用多孔介质理论验证用于测定通气患者肺泡二氧化碳含量的数学模型：利用多孔介质理论验证用于测定通气患者肺泡二氧化碳含量的数学模型：数学模型研究与前瞻性临床验证，模拟从血液到气道入口的二氧化碳交换：重症监护室：干预措施：无：测量和主要结果模型结果与患者数据对比显示，潮气末 CO2 (EtCO2)、CO2 曲线下面积和 PaCO2 的相关性分别为 0.918、0.954 和 0.995。判定系数（R2）分别为 0.843、0.910 和 0.990，显示了精确度和预测能力：结论：该数学模型显示出在肺部重症护理方面的潜力。结论：该数学模型在肺部重症护理中显示出潜力，尽管前景广阔，但实际应用还需要进一步验证、临床医生培训和针对患者的调整。临床应用需要反复验证和教育。

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来源期刊

Critical Care Medicine 医学-危重病医学

CiteScore

16.30

自引率

5.70%

发文量

728

审稿时长

2 months

期刊介绍： Critical Care Medicine is the premier peer-reviewed, scientific publication in critical care medicine. Directed to those specialists who treat patients in the ICU and CCU, including chest physicians, surgeons, pediatricians, pharmacists/pharmacologists, anesthesiologists, critical care nurses, and other healthcare professionals, Critical Care Medicine covers all aspects of acute and emergency care for the critically ill or injured patient. Each issue presents critical care practitioners with clinical breakthroughs that lead to better patient care, the latest news on promising research, and advances in equipment and techniques.