Association between metabolic syndrome and salivary MMP-8, myeloperoxidase in periodontitis.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Oral diseases Pub Date : 2025-01-01 Epub Date: 2024-06-09 DOI:10.1111/odi.15014

Julie Toby Thomas, Betsy Joseph, Sajit Varghese, Nebu George Thomas, Baiju Kamalasanan Vijayakumary, Timo Sorsa, Sukumaran Anil, Tuomas Waltimo

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Abstract

Objective: This study investigated the effect of metabolic syndrome (MetS) on periodontal clinical parameters and salivary biomarkers' matrix metalloproteinase-8 (MMP-8) and myeloperoxidase (MPO) in patients with periodontitis.

Methods: A total of 120 participants aged 25-55 were categorized into three groups: MetS with periodontitis (n = 40); systemically healthy with periodontitis (n = 40); and systemically and periodontally healthy controls (n = 40). Data collected included systemic parameters like waist circumference (WC), blood pressure (BP), high- and low-density lipoproteins, triglycerides (TG), fasting blood sugar (FBS), and glycated hemoglobin (HbA1c). Periodontal parameters estimated included bleeding on probing score (BoP), full-mouth plaque score (FMPS), periodontal probing depth (PPD), clinical attachment loss (CAL), and the number of missing teeth. Unstimulated whole saliva was analyzed via ELISA for active MMP-8 (aMMP-8), total MMP-8 (tMMP-8), and MPO.

Results: Participants with MetS and periodontitis exhibited significantly higher periodontal parameters, salivary aMMP-8, and MPO (26.26 vs. 24.1 ng/mL and 13.53 vs. 11.55 ng/mL compared to systemically healthy periodontitis patients) (all p < 0.01). Positive correlations occurred between aMMP-8 and WC, TG, and FBS (p < 0.01), and between MPO and WC, BP, and TG (p < 0.01).

Conclusions: The positive associations between these biomarkers and metabolic parameters indicate their potential utility for monitoring cardiovascular and glycemic risk in patients with periodontal disease.

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代谢综合征与牙周炎患者唾液中的 MMP-8、髓过氧化物酶之间的关系

研究目的本研究探讨了代谢综合征（MetS）对牙周炎患者牙周临床参数及唾液生物标志物基质金属蛋白酶-8（MMP-8）和髓过氧化物酶（MPO）的影响：将 120 名 25-55 岁的参与者分为三组：MetS伴牙周炎组（40人）；全身健康伴牙周炎组（40人）；全身和牙周健康对照组（40人）。收集的数据包括腰围（WC）、血压（BP）、高密度和低密度脂蛋白、甘油三酯（TG）、空腹血糖（FBS）和糖化血红蛋白（HbA1c）等系统参数。估计的牙周参数包括探诊出血评分（BoP）、全口牙菌斑评分（FMPS）、牙周探诊深度（PPD）、临床附着丧失（CAL）和缺失牙数量。通过酶联免疫吸附分析法对未受刺激的全唾液进行活性 MMP-8（aMMP-8）、总 MMP-8（tMMP-8）和 MPO 分析：结果：患有 MetS 和牙周炎的参与者的牙周参数、唾液中的 aMMP-8 和 MPO（与全身健康的牙周炎患者相比，分别为 26.26 vs. 24.1 ng/mL 和 13.53 vs. 11.55 ng/mL）明显更高（均为 p这些生物标志物与代谢参数之间的正相关表明，它们在监测牙周病患者的心血管和血糖风险方面具有潜在的实用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.