Effect of treatment of chronic hepatitis c virus patients with direct-acting anti-retroviral drugs on semen and hormonal parameters.

IF 1.8 Q3 OBSTETRICS & GYNECOLOGY Clinical and Experimental Reproductive Medicine-CERM Pub Date : 2024-06-10 DOI:10.5653/cerm.2023.06772
Yosra H Mahmoud, Basem Eysa, Eman Mohamed Salah Ahmed, Heba Abdelaziz, Ashgan Mohamed Zayed, Amin Abdel Baki, Ahmed Hosny, Mohamed Hassany
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Abstract

Objective: Hepatitis C virus (HCV) infection is known to influence the seminal and hormonal parameters of infected men. This study was performed to assess the effects of HCV clearance using direct-acting antiviral (DAA) agents on semen and hormonal parameters.

Methods: A total of 50 patients with chronic HCV were enrolled, and conventional semen analysis was performed according to World Health Organization guidelines. Basal levels of total testosterone, free testosterone (FT), follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), prolactin, and sex hormone-binding globulin (SHBG) were assessed before and 3 months after treatment with DAAs.

Results: Following DAA treatment, statistically significant increases were observed in sperm motility and the proportion of grade A sperm. Additionally, the percentage of abnormal forms was significantly decreased after treatment (p=0.000). However, no significant differences were observed in semen volume, concentration, or total sperm count. Sex hormone analysis of patients after DAA treatment revealed significant increases in FT, LH, and FSH levels, along with significant decreases in SHBG, prolactin, and E2 levels.

Conclusion: Following HCV clearance, we noted an improvement in sperm motility and an increase in the percentage of sperm with normal morphology. Treatment with DAAs was also associated with increased levels of FT and LH, along with decreased levels of SHBG, prolactin, and E2.

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用直接作用抗逆转录病毒药物治疗慢性丙型肝炎病毒患者对精液和激素参数的影响。
目的:众所周知,丙型肝炎病毒(HCV)感染会影响受感染男性的精液和激素参数。本研究旨在评估使用直接作用抗病毒药物(DAA)清除丙型肝炎病毒对精液和激素参数的影响:方法:共招募了 50 名慢性 HCV 患者,并根据世界卫生组织的指南进行了常规精液分析。在使用DAAs治疗前和治疗3个月后,对总睾酮、游离睾酮(FT)、卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、催乳素和性激素结合球蛋白(SHBG)的基础水平进行了评估:结果:接受 DAA 治疗后,精子活力和 A 级精子比例均有统计学意义的显著提高。此外,畸形精子的比例在治疗后也明显下降(P=0.000)。然而,精液量、浓度和精子总数均无明显差异。DAA治疗后对患者进行的性激素分析显示,FT、LH和FSH水平显著上升,SHBG、催乳素和E2水平显著下降:结论:HCV 清除后,我们注意到精子活力有所改善,形态正常的精子比例有所增加。DAAs治疗也与FT和LH水平升高以及SHBG、催乳素和E2水平降低有关。
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