The lncRNA Gm8097 is associated with hypospermatogenesis.

IF 1.6 Q3 OBSTETRICS & GYNECOLOGY Clinical and Experimental Reproductive Medicine-CERM Pub Date : 2024-12-01 Epub Date: 2024-06-10 DOI:10.5653/cerm.2024.06835

Bin Lei, Luwei Ye, Zhuolin Qiu, Shoubo Zhang

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Abstract

Objective: To investigate whether long non-coding RNA (lncRNA) Gm8097 (LncGm8097) is associated with male infertility.

Methods: The expression and bilogical role of LncGm8097 were investigated.

Results: LncGm8097 expression was down-regulated in the testis tissues with moderate and severe hypospermatogenesis compared with those with normal spermatogenesis and mild hypospermatogenesis (p<0.05). LncGm8097 down-regulation significantly promoted apoptosis and inhibited proliferation in GC1 and GC2 cells. In addition, LncGm8097 was significantly down-regulated in mouse model of hypospermatogenesis and correlated with cell apoptosis and proliferation. LncGm8097 was located immediately upstream of PRPS2, and correlated with Bcl-2/P53/caspase 6/caspase 9 signal pathway.

Conclusion: LncGm8097 down-regulation correlates with hypospermatogenesis, which may offer new insights into the pathogenesis of male infertility.

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lncRNA Gm8097 与精子发生功能低下有关。

目的研究长非编码RNA（lncRNA）Gm8097（LncGm8097）是否与男性不育有关：方法：研究LncGm8097的表达和生物学作用：结果：LncGm8097在中度和重度精子发生功能低下的睾丸组织中表达下调，而在精子发生正常和轻度精子发生功能低下的睾丸组织中表达上调：LncGm8097的下调与精子发生功能减退相关，这可能为男性不育症的发病机制提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Reproductive Medicine-CERM Multiple-

CiteScore

3.30

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0.00%

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