Dietary choline intake and its association with asthma: A study based on the National Health and Nutrition Examination Survey database

IF 4.6 2区医学 Q2 ALLERGY Clinical and Translational Allergy Pub Date : 2024-06-11 DOI:10.1002/clt2.12359

Jiaqiang Shi, Yuming Lin, Yingxiu Jiang, Guoguo Qiu, Fanghua Jian, Wei Lin, Shihao Zhang

{"title":"Dietary choline intake and its association with asthma: A study based on the National Health and Nutrition Examination Survey database","authors":"Jiaqiang Shi, Yuming Lin, Yingxiu Jiang, Guoguo Qiu, Fanghua Jian, Wei Lin, Shihao Zhang","doi":"10.1002/clt2.12359","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>This work endeavored to examine the correlation between dietary choline intake and the odds of asthma, utilizing data from the National Health and Nutrition Examination Survey (NHANES).</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Aggregated data from seven cycles (2005–2018) in the NHANES database were utilized. The independent variable was dietary choline intake, and the dependent variable was asthma. The weighted logistic regression method was used to construct a model reflecting the relationship between these two factors. This work employed stratified analysis without adjusting for confounding factors and subgroup analysis with adjusted confounding factors to mine the association between dietary choline intake and asthma. Additionally, restricted cubic spline analysis examined nonlinear associations of the two in age subgroups.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Forty five thousand and seven hundreds ninety seven samples were included here. The model indicating the relationship between dietary choline intake and asthma was constructed (OR: 0.86, 95% CI: 0.79–0.93, <i>p</i> < 0.001). Stratified analysis indicated that the interaction terms of age (<i>p</i> < 0.001) and body mass index (BMI) (<i>p</i> = 0.002) with dietary choline intake significantly influenced the relationship model. In the adjusted models, accounting for demographic characteristics, poverty impact ratio, BMI, exposure to environmental tobacco smoke, and total energy intake, an increase in dietary choline intake significantly reduced the odds of asthma (OR: 0.79, 95% CI: 0.72–0.88, <i>p</i> < 0.001). Subgroup analyses based on age and BMI revealed a significant negative correlation between dietary choline intake and the odds of asthma in the adult population (OR: 0.76, 95% CI: 0.67–0.86, <i>p</i> < 0.001), as well as in individuals with a BMI between 25 and 30 kg/m<sup>2</sup> (OR: 0.79, 95% CI: 0.63–0.99, <i>p</i> = 0.042), and those with a BMI >30 kg/m<sup>2</sup> (OR: 0.73, 95% CI: 0.60–0.89, <i>p</i> = 0.002).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Dietary choline intake was significantly inversely correlated with asthma prevalence, especially in adults and overweight/obese individuals, suggesting that increasing choline intake may reduce asthma risk. Further research is needed to explore this relationship and provide tailored dietary recommendations for different age and BMI groups to enhance asthma prevention and management.</p>\n </section>\n </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 6","pages":""},"PeriodicalIF":4.6000,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.12359","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Translational Allergy","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/clt2.12359","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ALLERGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

This work endeavored to examine the correlation between dietary choline intake and the odds of asthma, utilizing data from the National Health and Nutrition Examination Survey (NHANES).

Methods

Aggregated data from seven cycles (2005–2018) in the NHANES database were utilized. The independent variable was dietary choline intake, and the dependent variable was asthma. The weighted logistic regression method was used to construct a model reflecting the relationship between these two factors. This work employed stratified analysis without adjusting for confounding factors and subgroup analysis with adjusted confounding factors to mine the association between dietary choline intake and asthma. Additionally, restricted cubic spline analysis examined nonlinear associations of the two in age subgroups.

Results

Forty five thousand and seven hundreds ninety seven samples were included here. The model indicating the relationship between dietary choline intake and asthma was constructed (OR: 0.86, 95% CI: 0.79–0.93, p < 0.001). Stratified analysis indicated that the interaction terms of age (p < 0.001) and body mass index (BMI) (p = 0.002) with dietary choline intake significantly influenced the relationship model. In the adjusted models, accounting for demographic characteristics, poverty impact ratio, BMI, exposure to environmental tobacco smoke, and total energy intake, an increase in dietary choline intake significantly reduced the odds of asthma (OR: 0.79, 95% CI: 0.72–0.88, p < 0.001). Subgroup analyses based on age and BMI revealed a significant negative correlation between dietary choline intake and the odds of asthma in the adult population (OR: 0.76, 95% CI: 0.67–0.86, p < 0.001), as well as in individuals with a BMI between 25 and 30 kg/m² (OR: 0.79, 95% CI: 0.63–0.99, p = 0.042), and those with a BMI >30 kg/m² (OR: 0.73, 95% CI: 0.60–0.89, p = 0.002).

Conclusion

Dietary choline intake was significantly inversely correlated with asthma prevalence, especially in adults and overweight/obese individuals, suggesting that increasing choline intake may reduce asthma risk. Further research is needed to explore this relationship and provide tailored dietary recommendations for different age and BMI groups to enhance asthma prevention and management.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

膳食胆碱摄入量及其与哮喘的关系：基于国家健康与营养调查数据库的研究。

目的：本研究旨在利用美国国家健康与营养调查（NHANES）的数据，研究膳食胆碱摄入量与哮喘发病率之间的相关性：本研究试图利用美国国家健康与营养调查（NHANES）的数据，研究膳食胆碱摄入量与哮喘发病几率之间的相关性：方法：利用 NHANES 数据库中七个周期（2005-2018 年）的汇总数据。自变量为膳食胆碱摄入量，因变量为哮喘。利用加权逻辑回归法构建了反映这两个因素之间关系的模型。这项研究采用了不调整混杂因素的分层分析和调整混杂因素的亚组分析来挖掘膳食胆碱摄入量与哮喘之间的关系。此外，限制性三次样条分析还研究了两者在年龄分组中的非线性关联：研究共纳入了 45797 个样本。构建了表明膳食胆碱摄入量与哮喘之间关系的模型（OR：0.86，95% CI：0.79-0.93，P 2（OR：0.79，95% CI：0.63-0.99，P = 0.042），以及体重指数大于 30 kg/m2 者（OR：0.73，95% CI：0.60-0.89，P = 0.002）：结论：膳食中胆碱的摄入量与哮喘发病率呈明显的反向关系，尤其是在成人和超重/肥胖人群中，这表明增加胆碱的摄入量可降低哮喘风险。需要进一步研究探讨这种关系，并为不同年龄和体重指数群体提供有针对性的饮食建议，以加强哮喘的预防和管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Clinical and Translational Allergy Immunology and Microbiology-Immunology

CiteScore

7.50

自引率

4.50%

发文量

117

审稿时长

12 weeks

期刊介绍： Clinical and Translational Allergy, one of several journals in the portfolio of the European Academy of Allergy and Clinical Immunology, provides a platform for the dissemination of allergy research and reviews, as well as EAACI position papers, task force reports and guidelines, amongst an international scientific audience. Clinical and Translational Allergy accepts clinical and translational research in the following areas and other related topics: asthma, rhinitis, rhinosinusitis, drug hypersensitivity, allergic conjunctivitis, allergic skin diseases, atopic eczema, urticaria, angioedema, venom hypersensitivity, anaphylaxis, food allergy, immunotherapy, immune modulators and biologics, animal models of allergic disease, immune mechanisms, or any other topic related to allergic disease.