Prodromal or mild Alzheimer's disease: Influence of neuropsychiatric symptoms and premordid personality on caregivers' burden

IF 3.6 3区医学 Q2 GERIATRICS & GERONTOLOGY International Journal of Geriatric Psychiatry Pub Date : 2024-06-10 DOI:10.1002/gps.6114

J. M. Dorey, E. Pongan, C. Padovan, A. Chaillet, M. Herrmann, P. Krolak-Salmon, I. Rouch

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Abstract

Objective

In Alzheimer's disease (AD), the burden on caregivers is influenced by various factors, including the stage of disease progression and neuropsychiatric symptoms (NPS). To date, there has been limited research examining how patient's premorbid personality could affect this burden. The objective of this study was to investigate the impact of both premorbid personality and NPS in individuals with prodromal to mild AD on their caregivers' burden.

Method

One hundred eighty participants with prodromal or mild AD drown from the PACO (in French: Personnalité Alzheimer COmportement) cohort were included. Personality was assessed by the Revised NEO Personality Inventory (NEO-PI-R). Neuropsychiatric symptoms were measured with the short version of the Neuropsychiatric Inventory (NPI-Q), and caregiver burden was evaluated with the Zarit burden scale. Relationships between personality, Neuro-Psychiatric Inventory (NPI) scores, and caregiver burden were determined using multivariate linear regressions controlled for age, sex, educational level, and Mini Mental State Examination.

Results

The total NPI score was related to increased burden (beta = 0.45; p < 0.001). High level of neuroticism (beta = 0.254; p = 0.003) et low level of conscientiousness (beta = - 0.233; p = 0.005) were associated higher burden. Extraversion (beta = −0.185; p = 0.027) and conscientiousness (beta = −0.35; p = 0.006) were negatively associated with burden. In contrast, neuroticism, openness and agreeableness were not correlated with burden. When adjusted on total NPI score, the relationship between extraversion and conscientiousness didn't persist.

Conclusion

Our results suggest that premorbid personality of patients with prodromal to mild Alzheimer influence caregivers's burden, with a protective effect of a high level of extraversion and conscientiousness.

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前驱期或轻度阿尔茨海默病：神经精神症状和前驱人格对照顾者负担的影响。

目的：阿尔茨海默病（AD）患者的护理负担受多种因素影响，包括疾病进展阶段和神经精神症状（NPS）。迄今为止，有关患者病前性格如何影响这种负担的研究还很有限。本研究的目的是调查前驱人格和NPS对轻度AD前驱期患者照顾者负担的影响：研究纳入了 PACO（法语：Personnalité Alzheimer COmportement）队列中的 180 名前驱期或轻度 AD 患者。人格通过修订版NEO人格量表（NEO-PI-R）进行评估。神经精神症状通过简版神经精神量表（NPI-Q）进行测量，照顾者负担通过扎里特负担量表进行评估。人格、神经精神量表（NPI）得分和照顾者负担之间的关系是通过多变量线性回归确定的，并与年龄、性别、教育程度和迷你精神状态检查进行了控制：结果：NPI 总分与护理负担的增加有关（beta = 0.45；p 结论：NPI 总分与护理负担的增加有关：我们的研究结果表明，前驱期至轻度阿尔茨海默病患者的病前人格会影响照顾者的负担，而高水平的外向性和自觉性具有保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Geriatric Psychiatry 医学-精神病学

CiteScore

6.10

自引率

2.50%

发文量

168

审稿时长

4-8 weeks

期刊介绍： The rapidly increasing world population of aged people has led to a growing need to focus attention on the problems of mental disorder in late life. The aim of the Journal is to communicate the results of original research in the causes, treatment and care of all forms of mental disorder which affect the elderly. The Journal is of interest to psychiatrists, psychologists, social scientists, nurses and others engaged in therapeutic professions, together with general neurobiological researchers. The Journal provides an international perspective on the important issue of geriatric psychiatry, and contributions are published from countries throughout the world. Topics covered include epidemiology of mental disorders in old age, clinical aetiological research, post-mortem pathological and neurochemical studies, treatment trials and evaluation of geriatric psychiatry services.