Monitoring the effect of continuous topical oxygen therapy with near-infrared spectroscopy: a pilot case series in wound healing.

IF 1.4 4区医学 Q3 DERMATOLOGY Wounds : a compendium of clinical research and practice Pub Date : 2024-05-01

Windy Cole, Emma Woodmansey

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Abstract

Background: Sufficient oxygen is critical for multiple processes in wound healing. Nonhealing wounds have low tissue oxygen levels due to damaged microvasculature and comorbidities limiting tissue perfusion. Hypoxia may be reversed using continuous topical oxygen therapy (cTOT). Objective measures to identify and track hypoxic wounds and their response to adjunctive oxygen are key.

Objective: To understand the effect of cTOT on recalcitrant wounds by tracking wound area and changes in tissue oxygenation using a near-infrared spectroscopy (NIRS) device.

Materials and methods: Five patients with nonhealing wounds received treatment with cTOT over 5 weeks. Routine wound measures and tissue oxygenation were recorded over that period.

Results: Reductions in wound area and improvements in tissue oxygenation were seen in all 5 patients, with 3 patients healing within 5 weeks despite the previous long duration of their wounds. Trends in tissue oxygenation and relative wound surface area over the treatment period demonstrated a reduction in wound area as tissue oxygenation improved.

Conclusion: This case series reinforces previous studies that cTOT is an effective, noninvasive treatment as a key adjunct to standard care in nonhealing wounds. Moreover, point-of-care tools such as the NIRS imaging device provided objective information concerning tissue oxygenation improvements, thus giving useful insights to the clinician.

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利用近红外光谱监测持续局部氧疗的效果：伤口愈合试验性病例系列。

背景：充足的氧气对伤口愈合的多个过程至关重要。由于微血管受损和合并症限制了组织灌注，未愈合伤口的组织氧含量较低。使用持续局部氧疗（cTOT）可逆转缺氧状态。识别和跟踪缺氧伤口及其对辅助氧气的反应的客观措施是关键：通过使用近红外光谱（NIRS）设备跟踪伤口面积和组织氧合的变化，了解 cTOT 对顽固伤口的影响：五名伤口不愈合的患者接受了为期五周的 cTOT 治疗。在此期间记录了常规伤口测量和组织氧合情况：结果：所有 5 名患者的伤口面积都有所缩小，组织含氧量也有所改善，其中 3 名患者的伤口在 5 周内愈合，尽管他们的伤口持续时间较长。治疗期间组织含氧量和相对伤口表面积的变化趋势表明，随着组织含氧量的改善，伤口面积也在缩小：本系列病例证实了之前的研究结果，即 cTOT 是一种有效的非侵入性治疗方法，是不愈合伤口标准护理的重要辅助手段。此外，近红外成像设备等护理点工具提供了有关组织氧合改善的客观信息，从而为临床医生提供了有用的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Wounds : a compendium of clinical research and practice 医学-皮肤病学

CiteScore

1.50

自引率

11.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Wounds is the most widely read, peer-reviewed journal focusing on wound care and wound research. The information disseminated to our readers includes valuable research and commentaries on tissue repair and regeneration, biology and biochemistry of wound healing, and clinical management of various wound etiologies. Our multidisciplinary readership consists of dermatologists, general surgeons, plastic surgeons, vascular surgeons, internal medicine/family practitioners, podiatrists, gerontologists, researchers in industry or academia (PhDs), orthopedic surgeons, infectious disease physicians, nurse practitioners, and physician assistants. These practitioners must be well equipped to deal with a myriad of chronic wound conditions affecting their patients including vascular disease, diabetes, obesity, dermatological disorders, and more. Whether dealing with a traumatic wound, a surgical or non-skin wound, a burn injury, or a diabetic foot ulcer, wound care professionals turn to Wounds for the latest in research and practice in this ever-growing field of medicine.