Enlarged perivascular spaces in the basal ganglia are associated with arteries not veins.

IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-11-01 Epub Date: 2024-06-11 DOI:10.1177/0271678X241260629
Jan Oltmer, Hendrik Mattern, Julia Beck, Renat Yakupov, Steven M Greenberg, Jaco Jm Zwanenburg, Tine Arts, Emrah Düzel, Susanne J van Veluw, Stefanie Schreiber, Valentina Perosa
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Abstract

Enlarged perivascular spaces (EPVS) are common in cerebral small vessel disease (CSVD) and have been identified as a marker of dysfunctional brain clearance. However, it remains unknown if the enlargement occurs predominantly around arteries or veins. We combined in vivo ultra-high-resolution MRI and histopathology to investigate the spatial relationship of veins and arteries with EPVS within the basal ganglia (BG). Furthermore, we assessed the relationship between the EPVS and measures of blood-flow (blood-flow velocity, pulsatility index) in the small arteries of the BG. Twenty-four healthy controls, twelve non-CAA CSVD patients, and five probable CAA patients underwent a 3 tesla [T] and 7T MRI-scan, and EPVS, arteries, and veins within the BG were manually segmented. Furthermore, the scans were co-registered. Six autopsy-cases were also assessed. In the BG, EPVS were significantly closer to and overlapped more frequently with arteries than with veins. Histological analysis showed a higher proportion of BG EPVS surrounding arteries than veins. Finally, the pulsatility index of BG arteries correlated with EPVS volume. Our results are in line with previous works and establish a pathophysiological relationship between arteries and EPVS, contributing to elucidating perivascular clearance routes in the human brain.

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基底节中扩大的血管周围空间与动脉而非静脉有关。
血管周围间隙(EPVS)增大在脑小血管疾病(CSVD)中很常见,已被确定为脑清除功能障碍的标志物。然而,这种扩大主要发生在动脉还是静脉周围仍是未知数。我们结合活体超高分辨率磁共振成像和组织病理学研究了基底节(BG)内静脉和动脉与 EPVS 的空间关系。此外,我们还评估了 EPVS 与基底节小动脉血流测量值(血流速度、搏动指数)之间的关系。24 名健康对照者、12 名非 CAA CSVD 患者和 5 名疑似 CAA 患者接受了 3 特斯拉 [T] 和 7T MRI 扫描,并对 BG 内的 EPVS、动脉和静脉进行了人工分割。此外,还对扫描结果进行了联合注册。此外,还对六例尸检病例进行了评估。在 BG 中,EPVS 与动脉的距离和重叠频率明显高于静脉。组织学分析显示,围绕动脉的 BG EPVS 比例高于静脉。最后,BG 动脉的搏动指数与 EPVS 的体积相关。我们的研究结果与之前的研究结果一致,建立了动脉和 EPVS 之间的病理生理学关系,有助于阐明人脑血管周围的清除途径。
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来源期刊
Journal of Cerebral Blood Flow and Metabolism
Journal of Cerebral Blood Flow and Metabolism 医学-内分泌学与代谢
CiteScore
12.00
自引率
4.80%
发文量
300
审稿时长
3 months
期刊介绍: JCBFM is the official journal of the International Society for Cerebral Blood Flow & Metabolism, which is committed to publishing high quality, independently peer-reviewed research and review material. JCBFM stands at the interface between basic and clinical neurovascular research, and features timely and relevant research highlighting experimental, theoretical, and clinical aspects of brain circulation, metabolism and imaging. The journal is relevant to any physician or scientist with an interest in brain function, cerebrovascular disease, cerebral vascular regulation and brain metabolism, including neurologists, neurochemists, physiologists, pharmacologists, anesthesiologists, neuroradiologists, neurosurgeons, neuropathologists and neuroscientists.
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