Is It Possible to Use Inflammatory Markers as Potential Biomarkers for Chronic Urticaria?

IF 1.1 4区 医学 Q4 ALLERGY Pediatric Allergy Immunology and Pulmonology Pub Date : 2024-06-01 Epub Date: 2024-06-12 DOI:10.1089/ped.2024.0022
Gaye Kocatepe, Mehmet Akif Kaya, Aysen Bingol, Dilara Fatma Kocacik Uygun
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Abstract

Background: This study aimed to determine whether the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) at admission affect the transition of pediatric patients diagnosed with acute spontaneous urticaria to chronic urticaria. Methods: This study included 390 patients who presented to the Department of Pediatrics at Akdeniz University Hospital with acute spontaneous urticaria between January 2020 and December 2022. A statistical comparison was made between the hematological parameters of patients who developed chronic urticaria and those who did not. Neutrophil, lymphocyte, and platelet counts, as well as NLR, PLR, and SII ratios, were used for the comparison. Results: It was observed that acute urticaria progressed to chronic urticaria in 5.8% (n = 23) of the patients. No significant differences in lymphocyte, hemoglobin, and platelet counts were observed between the group progressing to chronic urticaria and the control group (P > 0.05). However, the chronic urticaria group had higher leukocyte and absolute neutrophil counts (P = 0.009 and P < 0.001, respectively). In addition, the NLR was significantly higher in the chronic urticaria group (P = 0.029), whereas no statistically significant difference was observed in the PLR (P = 0.180). The chronic urticaria group had a significantly higher SII than the control group (P = 0.011). Conclusion: Hematological parameters, particularly NLR and SII, may be useful indicators of the transition from acute to chronic urticaria in pediatric patients. The early identification of these markers could help monitor patients and guide treatment decisions. Further comprehensive studies are required to validate these findings.

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将炎症标记物作为慢性荨麻疹的潜在生物标记物是否可行?
研究背景本研究旨在确定入院时中性粒细胞-淋巴细胞比率(NLR)、血小板-淋巴细胞比率(PLR)和全身免疫炎症指数(SII)是否会影响确诊为急性自发性荨麻疹的儿科患者向慢性荨麻疹的转变。研究方法本研究纳入了 390 名在 2020 年 1 月至 2022 年 12 月期间因急性自发性荨麻疹到阿克登尼兹大学医院儿科就诊的患者。对发展为慢性荨麻疹的患者和未发展为慢性荨麻疹的患者的血液学参数进行了统计比较。比较采用了中性粒细胞、淋巴细胞和血小板计数以及 NLR、PLR 和 SII 比率。结果观察发现,急性荨麻疹发展为慢性荨麻疹的患者占 5.8%(23 人)。慢性荨麻疹进展组与对照组的淋巴细胞、血红蛋白和血小板计数无明显差异(P > 0.05)。然而,慢性荨麻疹组的白细胞和绝对中性粒细胞计数更高(分别为 P = 0.009 和 P <0.001)。此外,慢性荨麻疹组的 NLR 明显更高(P = 0.029),而 PLR 则无统计学差异(P = 0.180)。慢性荨麻疹组的 SII 明显高于对照组(P = 0.011)。结论血液学参数,尤其是 NLR 和 SII,可能是儿童患者从急性荨麻疹转变为慢性荨麻疹的有用指标。早期识别这些指标有助于监测患者并指导治疗决策。要验证这些发现,还需要进一步的综合研究。
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来源期刊
CiteScore
2.00
自引率
0.00%
发文量
23
审稿时长
>12 weeks
期刊介绍: Pediatric Allergy, Immunology, and Pulmonology is a peer-reviewed journal designed to promote understanding and advance the treatment of respiratory, allergic, and immunologic diseases in children. The Journal delivers original translational, clinical, and epidemiologic research on the most common chronic illnesses of children—asthma and allergies—as well as many less common and rare diseases. It emphasizes the developmental implications of the morphological, physiological, pharmacological, and sociological components of these problems, as well as the impact of disease processes on families. Pediatric Allergy, Immunology, and Pulmonology coverage includes: -Functional and genetic immune deficiencies- Interstitial lung diseases- Both common and rare respiratory, allergic, and immunologic diseases- Patient care- Patient education research- Public health policy- International health studies
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