The tryptophan metabolic pathway of the microbiome and host cells in health and disease.

IF 4.8 4区 医学 Q2 IMMUNOLOGY International immunology Pub Date : 2024-06-13 DOI:10.1093/intimm/dxae035
Kentaro Miyamoto, Tomohisa Sujino, Takanori Kanai
{"title":"The tryptophan metabolic pathway of the microbiome and host cells in health and disease.","authors":"Kentaro Miyamoto, Tomohisa Sujino, Takanori Kanai","doi":"10.1093/intimm/dxae035","DOIUrl":null,"url":null,"abstract":"<p><p>The intricate and dynamic tryptophan (Trp) metabolic pathway in both the microbiome and host cells highlights its profound implications for health and disease. This pathway involves complex interactions between host cellular and bacteria processes, producing bioactive compounds such as 5-Hydroxytryptamine (5-HT) and kynurenine (Kyn) derivatives. Immune responses to Trp metabolites through specific receptors have been explored, highlighting the role of the aryl hydrocarbon receptor (AHR) in inflammation modulation. Dysregulation of this pathway is implicated in various diseases, such as Alzheimer's and Parkinson's diseases, mood disorders, neuronal diseases, autoimmune diseases such as multiple sclerosis (MS), and cancer. In this article, we describe the impact of the 5-HT, Trp, indole, and Trp metabolites on health and disease. Further, we review the impact of microbiome-derived Trp metabolites that affect immune responses and contribute to maintaining homeostasis, especially in an experimental autoimmune encephalitis (EAE) model of MS.</p>","PeriodicalId":13743,"journal":{"name":"International immunology","volume":null,"pages":null},"PeriodicalIF":4.8000,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/intimm/dxae035","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

The intricate and dynamic tryptophan (Trp) metabolic pathway in both the microbiome and host cells highlights its profound implications for health and disease. This pathway involves complex interactions between host cellular and bacteria processes, producing bioactive compounds such as 5-Hydroxytryptamine (5-HT) and kynurenine (Kyn) derivatives. Immune responses to Trp metabolites through specific receptors have been explored, highlighting the role of the aryl hydrocarbon receptor (AHR) in inflammation modulation. Dysregulation of this pathway is implicated in various diseases, such as Alzheimer's and Parkinson's diseases, mood disorders, neuronal diseases, autoimmune diseases such as multiple sclerosis (MS), and cancer. In this article, we describe the impact of the 5-HT, Trp, indole, and Trp metabolites on health and disease. Further, we review the impact of microbiome-derived Trp metabolites that affect immune responses and contribute to maintaining homeostasis, especially in an experimental autoimmune encephalitis (EAE) model of MS.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
微生物组和宿主细胞在健康和疾病中的色氨酸代谢途径。
微生物组和宿主细胞中错综复杂而又充满活力的色氨酸(Trp)代谢途径凸显了其对健康和疾病的深远影响。这一途径涉及宿主细胞和细菌过程之间复杂的相互作用,产生生物活性化合物,如 5-羟色胺(5-HT)和犬尿氨酸(Kyn)衍生物。通过特定受体对 Trp 代谢物的免疫反应已得到探讨,其中突出了芳基烃受体(AHR)在炎症调节中的作用。这一途径的失调与多种疾病有关,如阿尔茨海默氏症和帕金森氏症、情绪障碍、神经元疾病、自身免疫性疾病(如多发性硬化症)和癌症。本文介绍了 5-羟色胺、Trp、吲哚和 Trp 代谢物对健康和疾病的影响。此外,我们还回顾了微生物衍生的 Trp 代谢物对免疫反应的影响以及对维持体内平衡的作用,尤其是在多发性硬化症的实验性自身免疫性脑炎 (EAE) 模型中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
International immunology
International immunology 医学-免疫学
CiteScore
9.30
自引率
2.30%
发文量
51
审稿时长
6-12 weeks
期刊介绍: International Immunology is an online only (from Jan 2018) journal that publishes basic research and clinical studies from all areas of immunology and includes research conducted in laboratories throughout the world.
期刊最新文献
Dysfunction of type 1 and type 2 immune cells: a lesson from exhausted-like ILC2s and their activation-induced cell death. The skin barrier and microbiome in infantile atopic dermatitis development: can skincare prevent onset? The role of dendritic cells in the instruction of helper T cells in the allergic march. Ro5-4864, a translocator protein ligand, regulates T cell-mediated inflammatory responses in skin. JunB is required for CD8+ T cell responses to acute infections.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1