Characterization of Adverse Outcomes from Legacy-Contaminated Groundwater Exposure to Early Life Stages of Fathead Minnow

IF 3.7 4区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Archives of Environmental Contamination and Toxicology Pub Date : 2024-06-13 DOI:10.1007/s00244-024-01069-7
Laura Gasque-Belz, Bradley Park, Steven Siciliano, Natacha Hogan, Lynn Weber, Patrick Campbell, Rachel Peters, Mark Hanson, Markus Hecker
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Abstract

Complex mixtures of chemicals present in groundwater at legacy-contaminated industrial sites can pose significant risks to adjacent surface waters. The combination of short-term molecular and chronic apical effect assessments is a promising approach to characterize the potential hazard of such complex mixtures. The objectives of this study were to: (1) assess the apical effects (survival, growth, development, and liver histopathology) after chronic exposure of early life stages (ELSs) of fathead minnows (FHM; Pimephales promelas) to contaminated groundwater from a legacy-contaminated pesticide manufacturing and packaging plant, and (2) identify possible molecular mechanisms responsible for these effects by comparing results to mechanistic outcomes previously determined by a short-term reduced transcriptome assay (EcoToxChips). This study revealed a significant increase in mortality and prevalence of spinal curvatures, as well as a significant reduction in the length of FHMs exposed to the groundwater mixtures in a concentration-dependent manner. There was an increasing trend in the prevalence of edema in FHMs, though not significantly different from controls. Additionally, no histopathological effects were observed in the liver of FHMs exposed to the groundwater mixtures. Short-term molecular outcomes determined in a parallel study were found to be informative of chronic apical outcomes, including cardiotoxicity, spinal deformities, and liver toxicity. Overall, the results observed in this study demonstrated that short-term transcriptomics analyses could support the hazard assessment of complex contaminated sites.

Graphical Abstract

Molecular outcomes were reflective of mortality and deformities, but uncertainties remained in the prediction of hepatotoxic effects at apical level.

Abstract Image

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确定黑头鲦鱼早期生命阶段接触遗留污染地下水的不良后果。
受遗留污染工业场地地下水中存在的复杂化学品混合物可能会对邻近地表水造成重大风险。结合短期分子评估和慢性根尖效应评估是描述此类复杂混合物潜在危害的一种可行方法。本研究的目标是(1)评估黑头鲦鱼(FHM;Pimephales promelas)早期生命阶段(ELSs)长期暴露于受污染地下水后的顶端效应(存活、生长、发育和肝脏组织病理学),该地下水来自一家受污染的农药制造和包装厂;(2)通过将结果与之前通过短期还原转录组测定(EcoToxChips)确定的机理结果进行比较,确定造成这些效应的可能分子机制。这项研究表明,暴露于地下水混合物中的甲壳虫死亡率和脊柱弯曲率明显增加,身长明显缩短,且与浓度有关。小尾寒羊水肿的发生率呈上升趋势,但与对照组相比没有显著差异。此外,在暴露于地下水混合物的 FHMs 的肝脏中未观察到组织病理学影响。在一项平行研究中确定的短期分子结果被认为可以反映出慢性根尖结果,包括心脏毒性、脊柱畸形和肝脏毒性。总之,本研究观察到的结果表明,短期转录组学分析可为复杂污染场地的危害评估提供支持。
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来源期刊
CiteScore
7.00
自引率
2.50%
发文量
63
审稿时长
8-16 weeks
期刊介绍: Archives of Environmental Contamination and Toxicology provides a place for the publication of timely, detailed, and definitive scientific studies pertaining to the source, transport, fate and / or effects of contaminants in the environment. The journal will consider submissions dealing with new analytical and toxicological techniques that advance our understanding of the source, transport, fate and / or effects of contaminants in the environment. AECT will now consider mini-reviews (where length including references is less than 5,000 words), which highlight case studies, a geographic topic of interest, or a timely subject of debate. AECT will also consider Special Issues on subjects of broad interest. The journal strongly encourages authors to ensure that their submission places a strong emphasis on ecosystem processes; submissions limited to technical aspects of such areas as toxicity testing for single chemicals, wastewater effluent characterization, human occupation exposure, or agricultural phytotoxicity are unlikely to be considered.
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