Expiratory and inspiratory resistance and reactance from respiratory oscillometry defining expiratory flow limitation in obstructive lung diseases

IF 1.3 4区医学 Q4 PHYSIOLOGY Clinical Physiology and Functional Imaging Pub Date : 2024-06-14 DOI:10.1111/cpf.12895

Abir Nasr, Georgia Papapostolou, Linnea Jarenbäck, Kerstin Romberg, Alf Tunsäter, Jaro Ankerst, Leif Bjermer, Ellen Tufvesson

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Abstract

Background

Expiratory flow limitation (EFL) during tidal breathing and lung hyperinflation have been identified as major decisive factors for disease status, prognosis and response to therapy in obstructive lung diseases.

Aim

To investigate the delta values between expiratory and inspiratory resistance and reactance, measured using respiratory oscillometry and its correlation with air trapping and symptoms in subjects with obstructive lung diseases.

Methods

Four hundred and seventy-one subjects (96 with chronic obstructive pulmonary disease [COPD], 311 with asthma, 30 healthy smokers and 34 healthy subjects) were included. Spirometry, body plethysmography and respiratory oscillometry measurements were performed and the differences between the expiratory and inspiratory respiratory oscillometry values (as delta values) were calculated. Questionnaires regarding symptoms and quality of life were administered.

Results

Patients with COPD and healthy smokers had an increased delta resistance at 5 Hz (R5) compared with patients with asthma (p < 0.0001 and p = 0.037, respectively) and healthy subjects (p = 0.0004 and p = 0.012, respectively). Patients with COPD also had higher values of ΔR5–R19 than healthy subjects (p = 0.0001) and patients with asthma (p < 0.0001). Delta reactance at 5 Hz (X5) was significantly more impaired in COPD patients than in asthma and healthy subjects (p < 0.0001 for all). There was a correlation between the ratio of residual volume and total lung capacity and ΔR5 (p = 0.0047; r = 0.32), ΔR5–R19 (p = 0.0002; r = 0.41) and ΔX5 (p < 0.0001; r = −0.44), for all subjects. ΔX5 correlated with symptoms in COPD, healthy smokers and patients with asthma. In addition, ΔR5 correlated with asthma symptoms.

Conclusion

EFL was most prominent in parameters measuring peripheral resistance and reactance and correlated with air trapping and airway symptoms.

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通过呼吸振荡仪确定阻塞性肺病呼气流量限制的呼气和吸气阻力及反应。

背景：目的：研究使用呼吸振荡仪测量的呼气和吸气阻力与反应之间的δ值及其与阻塞性肺部疾病患者的空气潴留和症状的相关性：方法：纳入 471 名受试者（96 名慢性阻塞性肺病患者、311 名哮喘患者、30 名健康吸烟者和 34 名健康受试者）。研究人员对受试者进行了肺活量测量、体温测量和呼吸振荡测量，并计算了呼气和吸气呼吸振荡测量值之间的差异（delta 值）。还进行了有关症状和生活质量的问卷调查：结果：与哮喘患者相比，慢性阻塞性肺病患者和健康吸烟者在 5 赫兹（R5）时的δ阻力增大（p 结论：慢性阻塞性肺病患者和健康吸烟者在 5 赫兹（R5）时的δ阻力增大：EFL在测量外周阻力和反应性的参数中最为突出，并与空气捕获和气道症状相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Physiology and Functional Imaging 医学-生理学

CiteScore

3.40

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Physiology and Functional Imaging publishes reports on clinical and experimental research pertinent to human physiology in health and disease. The scope of the Journal is very broad, covering all aspects of the regulatory system in the cardiovascular, renal and pulmonary systems with special emphasis on methodological aspects. The focus for the journal is, however, work that has potential clinical relevance. The Journal also features review articles on recent front-line research within these fields of interest. Covered by the major abstracting services including Current Contents and Science Citation Index, Clinical Physiology and Functional Imaging plays an important role in providing effective and productive communication among clinical physiologists world-wide.