Higher haemoglobin levels are associated with impaired periodontal status

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Journal of Clinical Periodontology Pub Date : 2024-06-14 DOI:10.1111/jcpe.14030

Atte Tapiola, Joona Tapio, Hannu Vähänikkilä, Paula Tegelberg, Pekka Ylöstalo, Peppi Koivunen

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Abstract

Aim

Cellular oxygen sensing mechanisms have been linked to periodontal condition, and levels of haemoglobin (Hb) (the main carrier of oxygen) can be used as a surrogate measure for hypoxia. We aimed to examine relations between Hb levels and key periodontal health parameters in a general population.

Materials and Methods

The population comprised 1711 (47% male) subjects from the Northern Finland Birth Cohort 1966, for whom an oral health examination was carried out at 46 years of age and whose Hb levels were within the Finnish reference values. Relative risks (RRs) were estimated using Poisson regression models.

Results

The low-Hb tertile (mean Hb 133 g/L) had healthier anthropometric, metabolic and periodontal health parameters than the high-Hb tertile (mean Hb 151 g/L). Multivariable regression models adjusted for risk factors showed Hb levels to be positively associated with alveolar bone loss (ABL) and periodontal pocket depth (PPD), although the associations were weaker after adjustment for key metabolic parameters and were strongly influenced by smoking status.

Conclusions

Hb levels within the normal variation are positively associated with PPD and ABL. The association between Hb levels and periodontal condition appeared to be more complex than had previously been anticipated.

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血红蛋白水平越高，牙周状况越差。

目的：细胞氧传感机制与牙周状况有关，血红蛋白（Hb）（氧气的主要载体）水平可作为缺氧的替代测量指标。我们旨在研究普通人群中血红蛋白水平与牙周健康主要参数之间的关系：研究对象包括来自 1966 年北芬兰出生队列的 1711 名受试者（47% 为男性），他们在 46 岁时接受了口腔健康检查，其 Hb 水平在芬兰参考值范围内。采用泊松回归模型估算了相对风险（RR）：结果：低 Hb 三分层（平均 Hb 133 g/L）的人体测量、代谢和牙周健康参数比高 Hb 三分层（平均 Hb 151 g/L）更健康。根据风险因素调整的多变量回归模型显示，血红蛋白水平与牙槽骨损失（ABL）和牙周袋深度（PPD）呈正相关，但在调整主要代谢参数后，相关性减弱，且受吸烟状况的影响较大：结论：正常范围内的 Hb 水平与 PPD 和 ABL 呈正相关。结论：正常变异范围内的 Hb 水平与 PPD 和 ABL 呈正相关。Hb 水平与牙周状况之间的关联似乎比之前预期的更为复杂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Periodontology 医学-牙科与口腔外科

CiteScore

13.30

自引率

10.40%

发文量

175

审稿时长

3-8 weeks

期刊介绍： Journal of Clinical Periodontology was founded by the British, Dutch, French, German, Scandinavian, and Swiss Societies of Periodontology. The aim of the Journal of Clinical Periodontology is to provide the platform for exchange of scientific and clinical progress in the field of Periodontology and allied disciplines, and to do so at the highest possible level. The Journal also aims to facilitate the application of new scientific knowledge to the daily practice of the concerned disciplines and addresses both practicing clinicians and academics. The Journal is the official publication of the European Federation of Periodontology but wishes to retain its international scope. The Journal publishes original contributions of high scientific merit in the fields of periodontology and implant dentistry. Its scope encompasses the physiology and pathology of the periodontium, the tissue integration of dental implants, the biology and the modulation of periodontal and alveolar bone healing and regeneration, diagnosis, epidemiology, prevention and therapy of periodontal disease, the clinical aspects of tooth replacement with dental implants, and the comprehensive rehabilitation of the periodontal patient. Review articles by experts on new developments in basic and applied periodontal science and associated dental disciplines, advances in periodontal or implant techniques and procedures, and case reports which illustrate important new information are also welcome.