Background: Biological ageing is characterised by a gradual decline in physiological functions, resulting in increased susceptibility to diseases and mortality. We investigated the relationship between edentulism and biological ageing among adults in England.
Methods: Data were drawn from participants in the English Longitudinal Study of Ageing who completed three consecutive biennial waves (waves 2-3-4 or 4-5-6), yielding 1889 individuals providing 2390 three-wave panel observations (mean age at baseline 68.1; men 47.7%). Edentulism was assessed in waves 3 and 5. Biological ageing was estimated using the Klemera and Doubal method, integrating multiple biomarkers assessed in waves 2, 4 and 6. Linear regression with clustered standard errors was employed to evaluate the association between edentulism and biological age in the subsequent wave (i.e., 2 years after the assessment of edentulism). Models were adjusted for pre-exposure confounders, including biological age, gender, socioeconomic status, existing health conditions and functional limitation assessed in the prior wave (i.e., 2 years before the assessment of edentulism).
Results: Participants with edentulism exhibited a 5.8-year greater biological age than those with some remaining teeth in the subsequent waves. After adjusting for confounding variables, edentulism was associated with a 0.82-year greater biological age than those with some remaining teeth (95% confidence interval: 0.40-1.24) in the subsequent waves.
Conclusion: Edentulism was longitudinally associated with a greater biological age. Strategies that incorporate oral health promotion, particularly the prevention of tooth loss, may contribute to healthy ageing.
{"title":"Association of Edentulism With Subsequent Biological Age: A Cohort Study.","authors":"Yusuke Matsuyama, Sakura Kiuchi, Jun Aida","doi":"10.1111/jcpe.70106","DOIUrl":"https://doi.org/10.1111/jcpe.70106","url":null,"abstract":"<p><strong>Background: </strong>Biological ageing is characterised by a gradual decline in physiological functions, resulting in increased susceptibility to diseases and mortality. We investigated the relationship between edentulism and biological ageing among adults in England.</p><p><strong>Methods: </strong>Data were drawn from participants in the English Longitudinal Study of Ageing who completed three consecutive biennial waves (waves 2-3-4 or 4-5-6), yielding 1889 individuals providing 2390 three-wave panel observations (mean age at baseline 68.1; men 47.7%). Edentulism was assessed in waves 3 and 5. Biological ageing was estimated using the Klemera and Doubal method, integrating multiple biomarkers assessed in waves 2, 4 and 6. Linear regression with clustered standard errors was employed to evaluate the association between edentulism and biological age in the subsequent wave (i.e., 2 years after the assessment of edentulism). Models were adjusted for pre-exposure confounders, including biological age, gender, socioeconomic status, existing health conditions and functional limitation assessed in the prior wave (i.e., 2 years before the assessment of edentulism).</p><p><strong>Results: </strong>Participants with edentulism exhibited a 5.8-year greater biological age than those with some remaining teeth in the subsequent waves. After adjusting for confounding variables, edentulism was associated with a 0.82-year greater biological age than those with some remaining teeth (95% confidence interval: 0.40-1.24) in the subsequent waves.</p><p><strong>Conclusion: </strong>Edentulism was longitudinally associated with a greater biological age. Strategies that incorporate oral health promotion, particularly the prevention of tooth loss, may contribute to healthy ageing.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Caroline H Henderzahs, Chiaki Yamada, Alexandr Morozov, Thelmalane Yalartai, Vanchit John, Hawra AlQallaf, Alexandru Movila
Aim(s): This cross-sectional clinical study aimed to explore the untargeted metabolomic and lipidomic profiles in gingival crevicular fluid (GCF) obtained from healthy individuals and patients with periodontitis.
Materials and methods: GCF was collected from 17 periodontally healthy and 19 periodontitis patients. For the unbiased characterisation of positively and negatively charged polar metabolite and lipid compounds, we employed hydrophilic interaction and reversed-phase liquid chromatography/mass spectrometry platforms, followed by a semisupervised deep learning-based approach for metabolomic peak curation and data analysis.
Results: A total of 256 metabolites were identified with Metabolomics Standards Initiative (MSI) confidence Levels 1-3, including 198 elevated and 58 diminished compounds in periodontal lesions (q < 0.05, |log2-transformed Fold Change (FC)| > 1). Periodontitis samples exhibited a significant positive accumulation of purine degradation and ceramide metabolites, along with a negative regulation of oxy fatty acids metabolism. Additionally, we observed a significant increase in established periodontitis biomarkers, including N-acetylneuraminic acid, citrulline and 2-pyrrolidineacetic acid. The study also characterised distinct differences in bacterial and fungal metabolite profiles between the healthy and diseased samples.
Conclusions: These findings suggest that untargeted metabolomic screening of GCF may significantly improve our understanding of biochemical changes between healthy tissue and periodontitis. This knowledge is pivotal for the development of a precision paradigm in periodontitis.
{"title":"Untargeted Metabolomic and Lipidomic Profiles of Gingival Crevicular Fluid in the Context of Periodontitis.","authors":"Caroline H Henderzahs, Chiaki Yamada, Alexandr Morozov, Thelmalane Yalartai, Vanchit John, Hawra AlQallaf, Alexandru Movila","doi":"10.1111/jcpe.70105","DOIUrl":"https://doi.org/10.1111/jcpe.70105","url":null,"abstract":"<p><strong>Aim(s): </strong>This cross-sectional clinical study aimed to explore the untargeted metabolomic and lipidomic profiles in gingival crevicular fluid (GCF) obtained from healthy individuals and patients with periodontitis.</p><p><strong>Materials and methods: </strong>GCF was collected from 17 periodontally healthy and 19 periodontitis patients. For the unbiased characterisation of positively and negatively charged polar metabolite and lipid compounds, we employed hydrophilic interaction and reversed-phase liquid chromatography/mass spectrometry platforms, followed by a semisupervised deep learning-based approach for metabolomic peak curation and data analysis.</p><p><strong>Results: </strong>A total of 256 metabolites were identified with Metabolomics Standards Initiative (MSI) confidence Levels 1-3, including 198 elevated and 58 diminished compounds in periodontal lesions (q < 0.05, |log<sub>2</sub>-transformed Fold Change (FC)| > 1). Periodontitis samples exhibited a significant positive accumulation of purine degradation and ceramide metabolites, along with a negative regulation of oxy fatty acids metabolism. Additionally, we observed a significant increase in established periodontitis biomarkers, including N-acetylneuraminic acid, citrulline and 2-pyrrolidineacetic acid. The study also characterised distinct differences in bacterial and fungal metabolite profiles between the healthy and diseased samples.</p><p><strong>Conclusions: </strong>These findings suggest that untargeted metabolomic screening of GCF may significantly improve our understanding of biochemical changes between healthy tissue and periodontitis. This knowledge is pivotal for the development of a precision paradigm in periodontitis.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction to ‘Implant‐Prosthodontic Rehabilitation of Partially Edentulous Jaw: From Bone Augmentation to Implant Placement and Soft Tissue Reconstruction—A Case Report’","authors":"","doi":"10.1111/jcpe.70081","DOIUrl":"https://doi.org/10.1111/jcpe.70081","url":null,"abstract":"","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"301 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146122026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AIMTo compare non-surgical subgingival re-instrumentation with an oscillating chitosan brush (OCB), with and without a novel chitosan hydrogel (LGX), in residual or recurrent pockets in step 3 or 4 of stage III-IV periodontitis patients.MATERIALS AND METHODSPatients presenting with residual 5-8 mm probing pocket depth (PPD) and modified bleeding on probing (mBOP) scores of 2 or 3 at 3-8 teeth were randomly assigned to treatment with either an OCB alone or OCB combined with LGX gel. Treatment was repeated at 3 months. Examinations took place at baseline (BL) and at 1 (Tp1), 3 (Tp2) and 6 months (Tp3) thereafter. Primary outcomes comprised changes in PPD, mBOP and pocket closure (PC).RESULTSThirty-eight patients were included in the analysis. Both treatments resulted in significant PPD and mBOP reductions at all follow-ups. However, sites treated with adjunctive LGX resulted in significantly greater PPD reductions and higher rates of PC compared to OCB alone (Tp2: PPD reductions 1.55 vs. 1.04, p < 0.001; PC: 67.1% vs. 46.4%, p < 0.001; Tp3: PPD reductions 1.73 vs. 1.33, p = 0.001; PC: 76.8% vs. 60.8%, p < 0.01).CONCLUSIONAdjunctive LGX gel application enhanced the efficacy of repeated subgingival re-instrumentation with OCB, reducing the need for additional step 3 interventions.TRIAL REGISTRATIONClinicalTrials.gov identification number: NCT05773911, first submitted: 2022-09-15 (https://clinicaltrials.gov/study/NCT05773911).
{"title":"Treatment of Residual Pockets in Stage III and IV Periodontitis Using an Oscillating Chitosan Device With or Without a Chitosan Gel-A Randomised Parallel-Arms Clinical Trial.","authors":"Ole Klein,Maria G Balta,Johan Caspar Wohlfahrt","doi":"10.1111/jcpe.70086","DOIUrl":"https://doi.org/10.1111/jcpe.70086","url":null,"abstract":"AIMTo compare non-surgical subgingival re-instrumentation with an oscillating chitosan brush (OCB), with and without a novel chitosan hydrogel (LGX), in residual or recurrent pockets in step 3 or 4 of stage III-IV periodontitis patients.MATERIALS AND METHODSPatients presenting with residual 5-8 mm probing pocket depth (PPD) and modified bleeding on probing (mBOP) scores of 2 or 3 at 3-8 teeth were randomly assigned to treatment with either an OCB alone or OCB combined with LGX gel. Treatment was repeated at 3 months. Examinations took place at baseline (BL) and at 1 (Tp1), 3 (Tp2) and 6 months (Tp3) thereafter. Primary outcomes comprised changes in PPD, mBOP and pocket closure (PC).RESULTSThirty-eight patients were included in the analysis. Both treatments resulted in significant PPD and mBOP reductions at all follow-ups. However, sites treated with adjunctive LGX resulted in significantly greater PPD reductions and higher rates of PC compared to OCB alone (Tp2: PPD reductions 1.55 vs. 1.04, p < 0.001; PC: 67.1% vs. 46.4%, p < 0.001; Tp3: PPD reductions 1.73 vs. 1.33, p = 0.001; PC: 76.8% vs. 60.8%, p < 0.01).CONCLUSIONAdjunctive LGX gel application enhanced the efficacy of repeated subgingival re-instrumentation with OCB, reducing the need for additional step 3 interventions.TRIAL REGISTRATIONClinicalTrials.gov identification number: NCT05773911, first submitted: 2022-09-15 (https://clinicaltrials.gov/study/NCT05773911).","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"37 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AIMTo assess whether daily use of calibrated interdental brushes can reduce gingival bleeding in pregnant women at high risk of preeclampsia.MATERIALS AND METHODSIn this multi-centre randomised controlled trial, 323 nulliparous women at risk of preeclampsia and with an intact periodontium were enrolled at 12 weeks of gestation. Participants were randomly allocated (1:1) to either: (i) the intervention group receiving individualised interdental hygiene instructions and calibrated interdental brushes for daily use, or (ii) the control group: receiving routine antenatal care. All participants were recalled at 1 week after baseline, 4, 5 and 8 months of pregnancy for assessments of bleeding on probing (BOP) and other periodontal indices. Linear mixed models were used to assess changes in bleeding over time, and logistic regression was used to evaluate predictors of bleeding resolution at the final follow-up.RESULTSAt 8 months of pregnancy, the intervention group showed a significant reduction in gingival bleeding, from 56% at baseline to 12% (-79.9%, p < 0.001), whereas the control group remained stable. Most of the improvement occurred during the first week (-56.8%). Among participants with severe baseline bleeding (> 81%), the reduction reached 84.3% (p < 0.05). Longitudinal analysis confirmed sustained reductions at each follow-up. Interdental brushing was the strongest independent predictor of bleeding reduction (OR = 3.14; 95% CI: 2.01-4.90).CONCLUSIONSDaily use of calibrated interdental brushes, introduced early in pregnancy, significantly reduced gingival bleeding with rapid and sustained effects. These findings support the feasibility and clinical relevance of individualised interdental hygiene as a preventive strategy within standard antenatal oral health care.TRIAL REGISTRATIONClinicalTrials.gov NCT04989075 (https://clinicaltrials.gov/study/NCT04989075).
{"title":"Impact of Interdental Brushing on Pregnancy-Associated Gingivitis: A Secondary Analysis of a Randomised Controlled Trial.","authors":"Florence Carrouel,Aida Kanoute,Daouda Faye,Marta Mazur,Hervé Perrier,Flavia Vitiello,Roman Ardan,Céline Clément,Romain Lan,Denis Bourgeois","doi":"10.1111/jcpe.70085","DOIUrl":"https://doi.org/10.1111/jcpe.70085","url":null,"abstract":"AIMTo assess whether daily use of calibrated interdental brushes can reduce gingival bleeding in pregnant women at high risk of preeclampsia.MATERIALS AND METHODSIn this multi-centre randomised controlled trial, 323 nulliparous women at risk of preeclampsia and with an intact periodontium were enrolled at 12 weeks of gestation. Participants were randomly allocated (1:1) to either: (i) the intervention group receiving individualised interdental hygiene instructions and calibrated interdental brushes for daily use, or (ii) the control group: receiving routine antenatal care. All participants were recalled at 1 week after baseline, 4, 5 and 8 months of pregnancy for assessments of bleeding on probing (BOP) and other periodontal indices. Linear mixed models were used to assess changes in bleeding over time, and logistic regression was used to evaluate predictors of bleeding resolution at the final follow-up.RESULTSAt 8 months of pregnancy, the intervention group showed a significant reduction in gingival bleeding, from 56% at baseline to 12% (-79.9%, p < 0.001), whereas the control group remained stable. Most of the improvement occurred during the first week (-56.8%). Among participants with severe baseline bleeding (> 81%), the reduction reached 84.3% (p < 0.05). Longitudinal analysis confirmed sustained reductions at each follow-up. Interdental brushing was the strongest independent predictor of bleeding reduction (OR = 3.14; 95% CI: 2.01-4.90).CONCLUSIONSDaily use of calibrated interdental brushes, introduced early in pregnancy, significantly reduced gingival bleeding with rapid and sustained effects. These findings support the feasibility and clinical relevance of individualised interdental hygiene as a preventive strategy within standard antenatal oral health care.TRIAL REGISTRATIONClinicalTrials.gov NCT04989075 (https://clinicaltrials.gov/study/NCT04989075).","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"49 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146005386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mario Aimetti, Federica Romano, Luigi Costanzo, Mario De Caroli, Andrea Di Venanzio, Giulia Maria Mariani, Giacomo Baima
Aim: To describe the efficacy of steps I-II-III of periodontal therapy performed in a specialist university setting following EFP S3 treatment guideline and to assess factors associated with the achievement of endpoints of therapy (EoT).
Methods: Records of 131 stage III-IV periodontitis patients were collected retrospectively. Residual pockets (probing pocket depth [PPD] 5 mm with bleeding on probing [BoP] or PPD ≥ 6 mm) after steps I-II (T1) received repeated subgingival instrumentation (RSI) or surgery and were re-evaluated after 1 year (T2). EoT (no PPD ≥ 5 mm BoP+ and no PPD ≥ 6 mm) rate at T1 and T2 was computed, and predictors explored through multilevel analyses.
Results: At T1, EoT was 67.8%, with step III yielding an additional 90.0% of EoT in PPD = 5 mm BoP+ and 85.3% in PPD ≥ 6 mm. Factors negatively associated with EoT were: posterior teeth, furcation involvement (degree II-III), initial PPD, interproximal location and plaque. When considering only pockets ≥ 6 mm, factors were PPD at T1, type of intervention (resective surgery over RSI) and plaque at T2. Overall, 55.7% of patients reached EoT, 16.1% achieved 'stable periodontitis' (PPD ≤ 4 mm, no PPD = 4 mm BoP+, BoP < 10%).
Conclusions: Guideline-based periodontal therapy achieved EoT targets in 93.3% of sites and 50% of patients with Stage III-IV periodontitis.
目的：描述在专业大学环境下遵循EFP S3治疗指南进行牙周治疗的步骤I-II-III的疗效，并评估与实现治疗终点（EoT）相关的因素。方法：对131例iii ~ iv期牙周炎患者的临床资料进行回顾性分析。步骤I-II （T1）后的残余口袋（探查口袋深度[PPD] 5mm，探查时出血[BoP]或PPD≥6mm）接受反复龈下检查（RSI）或手术，并在1年后重新评估（T2）。计算T1和T2的EoT（无PPD≥5 mm BoP+和无PPD≥6 mm）率，并通过多水平分析探讨预测因素。结果：T1时EoT率为67.8%，其中PPD = 5 mm BoP+的EoT率为90.0%，PPD≥6 mm的EoT率为85.3%。与EoT负相关的因素有：后牙、分叉受累程度（II-III度）、初始PPD、近端间位置和牙菌斑。当仅考虑≥6mm囊袋时，T1时的影响因素是PPD，干预类型（RSI切除手术）和T2时的斑块。总体而言，55.7%的患者达到了EoT， 16.1%的患者达到了“稳定牙周炎”（PPD≤4 mm，无PPD = 4 mm BoP+, BoP）。结论：基于指南的牙周治疗在93.3%的部位和50%的III-IV期牙周炎患者达到了EoT目标。
{"title":"Outcomes of Active Periodontal Therapy in a Specialist University Setting Following EFP S3 Treatment Guideline in Stage III-IV Periodontitis Patients.","authors":"Mario Aimetti, Federica Romano, Luigi Costanzo, Mario De Caroli, Andrea Di Venanzio, Giulia Maria Mariani, Giacomo Baima","doi":"10.1111/jcpe.70087","DOIUrl":"https://doi.org/10.1111/jcpe.70087","url":null,"abstract":"<p><strong>Aim: </strong>To describe the efficacy of steps I-II-III of periodontal therapy performed in a specialist university setting following EFP S3 treatment guideline and to assess factors associated with the achievement of endpoints of therapy (EoT).</p><p><strong>Methods: </strong>Records of 131 stage III-IV periodontitis patients were collected retrospectively. Residual pockets (probing pocket depth [PPD] 5 mm with bleeding on probing [BoP] or PPD ≥ 6 mm) after steps I-II (T1) received repeated subgingival instrumentation (RSI) or surgery and were re-evaluated after 1 year (T2). EoT (no PPD ≥ 5 mm BoP+ and no PPD ≥ 6 mm) rate at T1 and T2 was computed, and predictors explored through multilevel analyses.</p><p><strong>Results: </strong>At T1, EoT was 67.8%, with step III yielding an additional 90.0% of EoT in PPD = 5 mm BoP+ and 85.3% in PPD ≥ 6 mm. Factors negatively associated with EoT were: posterior teeth, furcation involvement (degree II-III), initial PPD, interproximal location and plaque. When considering only pockets ≥ 6 mm, factors were PPD at T1, type of intervention (resective surgery over RSI) and plaque at T2. Overall, 55.7% of patients reached EoT, 16.1% achieved 'stable periodontitis' (PPD ≤ 4 mm, no PPD = 4 mm BoP+, BoP < 10%).</p><p><strong>Conclusions: </strong>Guideline-based periodontal therapy achieved EoT targets in 93.3% of sites and 50% of patients with Stage III-IV periodontitis.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146003278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu Xie, Alejandro Artacho, Xiaoyu Yu, Mengning Bi, Hairui Li, Yuan Li, Andrea Roccuzzo, Alex Mira, Bob T. Rosier, Maurizio S. Tonetti
Aims To investigate the associations between oral‐rinse microbiota and distinct oral conditions, and further evaluate its potential ability to distinguish periodontitis severity. Methods Oral‐rinse‐sourced microbiota with 16S ribosomal RNA sequencing from 3770 adults in US National Health and Nutrition Examination Survey 2009–2012 were analysed across oral health, caries, periodontitis, co‐existing caries and periodontitis and edentulism. Diagnostic potential of the oral‐rinse microbiota for periodontitis severity was evaluated using multi‐class random forest (RF) model with internal validation and external validation in an independent cohort ( n = 392). Results Oral condition accounted for substantial variance in oral‐rinse microbiota, revealing disease or tooth loss–associated shifts. Increasing acidogenic/aciduric taxa ( Veillonella , Lactobacillus , Atopobium ) or periodontitis‐associated taxa ( Filifactor , Treponema , Tannerella ) were identified in caries‐only or periodontitis‐only groups, respectively, while the co‐existing disease group showed overlapping shifts. Taxa shifted dose‐dependently with increasing periodontitis severity. The RF model achieved moderate performance in identifying severe periodontitis, with the area under the receiver operating characteristic curve (AUROC) of 0.81 (0.75–0.87) internally and 0.83 (0.77–0.88) externally. Key contributing taxa aligned with established periodontitis‐associated genera, supporting model interpretability. Conclusion Based on our results, oral‐rinse microbiota captures disease‐specific signatures across oral conditions, supporting its potential as a non‐invasive tool to monitor oral microbial ecology and assess periodontitis severity at the population level.
{"title":"Oral‐Rinse‐Sourced Microbiota in Oral Health and Diseases in a Representative US Adult Population: Implications for Diagnostics","authors":"Yu Xie, Alejandro Artacho, Xiaoyu Yu, Mengning Bi, Hairui Li, Yuan Li, Andrea Roccuzzo, Alex Mira, Bob T. Rosier, Maurizio S. Tonetti","doi":"10.1111/jcpe.70101","DOIUrl":"https://doi.org/10.1111/jcpe.70101","url":null,"abstract":"Aims To investigate the associations between oral‐rinse microbiota and distinct oral conditions, and further evaluate its potential ability to distinguish periodontitis severity. Methods Oral‐rinse‐sourced microbiota with 16S ribosomal RNA sequencing from 3770 adults in US National Health and Nutrition Examination Survey 2009–2012 were analysed across oral health, caries, periodontitis, co‐existing caries and periodontitis and edentulism. Diagnostic potential of the oral‐rinse microbiota for periodontitis severity was evaluated using multi‐class random forest (RF) model with internal validation and external validation in an independent cohort ( <jats:italic>n</jats:italic> = 392). Results Oral condition accounted for substantial variance in oral‐rinse microbiota, revealing disease or tooth loss–associated shifts. Increasing acidogenic/aciduric taxa ( <jats:italic>Veillonella</jats:italic> , <jats:italic>Lactobacillus</jats:italic> , <jats:italic>Atopobium</jats:italic> ) or periodontitis‐associated taxa ( <jats:italic>Filifactor</jats:italic> , <jats:italic>Treponema</jats:italic> , <jats:italic>Tannerella</jats:italic> ) were identified in caries‐only or periodontitis‐only groups, respectively, while the co‐existing disease group showed overlapping shifts. Taxa shifted dose‐dependently with increasing periodontitis severity. The RF model achieved moderate performance in identifying severe periodontitis, with the area under the receiver operating characteristic curve (AUROC) of 0.81 (0.75–0.87) internally and 0.83 (0.77–0.88) externally. Key contributing taxa aligned with established periodontitis‐associated genera, supporting model interpretability. Conclusion Based on our results, oral‐rinse microbiota captures disease‐specific signatures across oral conditions, supporting its potential as a non‐invasive tool to monitor oral microbial ecology and assess periodontitis severity at the population level.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"40 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145968458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sahar Baniameri,Parham Hazrati,Hamoun Sabri,Abdusalam E Alrmali,Lucrezia Parma-Benfenati,Saeed A ElRefaei,Hom-Lay Wang,Muhammad H A Saleh
AIMLimited bone support in suprabony defects hinders predictable regeneration, but adjunctive biologics can improve results. This systematic review and meta-analysis aimed to evaluate the clinical efficacy of adjunctive biologics combined with open flap debridement (OFD) compared with OFD alone when treating suprabony defects.MATERIALS AND METHODSA systematic literature search was performed to identify controlled trials evaluating adult patients presenting horizontal periodontal defects. The primary outcome included residual probing depth (PD). Random-effects meta-analyses were performed; heterogeneity was assessed using I2 statistics; risk of bias was evaluated using Cochrane RoB-2; and evidence of quality was appraised via the GRADE framework.RESULTSNine studies comprising 303 patients were included. Adjunctive use of biologics-including enamel matrix derivative (EMD), platelet-rich fibrin (PRF) and hyaluronic acid (HA)-significantly enhanced clinical outcomes compared to OFD alone, with pooled mean differences favouring EMD and PRF for both residual PD (-0.89 and -0.42 mm) and clinical attachment level (CAL) (-1.32 and -0.69 mm). While subgroup differences were observed, notably with EMD, high heterogeneity was present for CAL and PD, and evidence of certainty ranged from low to very low.CONCLUSIONAdjunctive biologics improve clinical outcomes in suprabony periodontal defects; however, rigorous standardised trials are needed for reaching firm conclusions.
{"title":"Efficacy of Biologics for Surgical Treatment of Periodontal Suprabony Defects: A Systematic Review and Meta-Analysis of Controlled Clinical Trials.","authors":"Sahar Baniameri,Parham Hazrati,Hamoun Sabri,Abdusalam E Alrmali,Lucrezia Parma-Benfenati,Saeed A ElRefaei,Hom-Lay Wang,Muhammad H A Saleh","doi":"10.1111/jcpe.70078","DOIUrl":"https://doi.org/10.1111/jcpe.70078","url":null,"abstract":"AIMLimited bone support in suprabony defects hinders predictable regeneration, but adjunctive biologics can improve results. This systematic review and meta-analysis aimed to evaluate the clinical efficacy of adjunctive biologics combined with open flap debridement (OFD) compared with OFD alone when treating suprabony defects.MATERIALS AND METHODSA systematic literature search was performed to identify controlled trials evaluating adult patients presenting horizontal periodontal defects. The primary outcome included residual probing depth (PD). Random-effects meta-analyses were performed; heterogeneity was assessed using I2 statistics; risk of bias was evaluated using Cochrane RoB-2; and evidence of quality was appraised via the GRADE framework.RESULTSNine studies comprising 303 patients were included. Adjunctive use of biologics-including enamel matrix derivative (EMD), platelet-rich fibrin (PRF) and hyaluronic acid (HA)-significantly enhanced clinical outcomes compared to OFD alone, with pooled mean differences favouring EMD and PRF for both residual PD (-0.89 and -0.42 mm) and clinical attachment level (CAL) (-1.32 and -0.69 mm). While subgroup differences were observed, notably with EMD, high heterogeneity was present for CAL and PD, and evidence of certainty ranged from low to very low.CONCLUSIONAdjunctive biologics improve clinical outcomes in suprabony periodontal defects; however, rigorous standardised trials are needed for reaching firm conclusions.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"41 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145971832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roberto Farina,Anna Simonelli,Leonardo Trombelli,Ren Jie Jacob Chew,Yu-Kang Tu,Philip M Preshaw
AIMTo evaluate the efficacy of professional mechanical plaque removal (PMPR) for treating naturally occurring dental biofilm-induced gingivitis (i) compared to no treatment or oral hygiene instructions (OHI) (FQ1), (ii) when performed through different modalities (FQ2) or (iii) when combined with professionally administered local adjuncts (FQ3).MATERIALS AND METHODSA structured literature search was conducted for randomised or non-randomised controlled trials (RCTs and CTs) assessing gingival inflammation at patient level within 2-6 weeks after treatment in adults with gingivitis.RESULTSHeterogeneous evidence shows with low certainty that PMPR has no efficacy in patients continuing with ineffective self-performed oral hygiene regimens but enhances OHI outcomes (FQ1; three RCTs, one CT). Split-mouth RCTs consistently indicated with very low certainty that ultrasonic scaling (US) plus air polishing is as effective but less time consuming than US plus polishing with rubber cup and prophylaxis paste. Furthermore, diode laser shows no adjunctive benefit (FQ2; five RCTs). Although some professionally administered local adjuncts have shown positive outcomes in patients receiving PMPR, their broader clinical application is limited due to unresolved clinical issues and uncertain cost effectiveness (FQ3; two RCTs).CONCLUSIONSOHI should be the first-line treatment for dental biofilm-induced gingivitis. Combination of PMPR and OHI provides an adjunctive benefit over OHI alone. Air polishing may be combined with US to reduce the time for PMPR administration.
{"title":"Clinical Efficacy of Interventions Based on Professional Mechanical Plaque Removal in the Treatment of Dental Biofilm-Induced Gingivitis: A Systematic Review and Meta-Analysis.","authors":"Roberto Farina,Anna Simonelli,Leonardo Trombelli,Ren Jie Jacob Chew,Yu-Kang Tu,Philip M Preshaw","doi":"10.1111/jcpe.70083","DOIUrl":"https://doi.org/10.1111/jcpe.70083","url":null,"abstract":"AIMTo evaluate the efficacy of professional mechanical plaque removal (PMPR) for treating naturally occurring dental biofilm-induced gingivitis (i) compared to no treatment or oral hygiene instructions (OHI) (FQ1), (ii) when performed through different modalities (FQ2) or (iii) when combined with professionally administered local adjuncts (FQ3).MATERIALS AND METHODSA structured literature search was conducted for randomised or non-randomised controlled trials (RCTs and CTs) assessing gingival inflammation at patient level within 2-6 weeks after treatment in adults with gingivitis.RESULTSHeterogeneous evidence shows with low certainty that PMPR has no efficacy in patients continuing with ineffective self-performed oral hygiene regimens but enhances OHI outcomes (FQ1; three RCTs, one CT). Split-mouth RCTs consistently indicated with very low certainty that ultrasonic scaling (US) plus air polishing is as effective but less time consuming than US plus polishing with rubber cup and prophylaxis paste. Furthermore, diode laser shows no adjunctive benefit (FQ2; five RCTs). Although some professionally administered local adjuncts have shown positive outcomes in patients receiving PMPR, their broader clinical application is limited due to unresolved clinical issues and uncertain cost effectiveness (FQ3; two RCTs).CONCLUSIONSOHI should be the first-line treatment for dental biofilm-induced gingivitis. Combination of PMPR and OHI provides an adjunctive benefit over OHI alone. Air polishing may be combined with US to reduce the time for PMPR administration.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"19 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145961601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jarno Hakkers,Yvonne C M de Waal,Barzi Gareb,Henny J A Meijer,Gerry M Raghoebar
AIMTo analyse the effect of systemic amoxicillin and metronidazole on surgical peri-implantitis treatment with a follow-up period of 1 year.MATERIALS AND METHODSFifty-nine patients were randomly assigned to receive peri-implantitis surgery supplemented with (29 patients; test) or without (30 patients; control) systemic amoxicillin and metronidazole, in cases with no, one-wall or two-wall bony defects. Primary outcomes were mean peri-implant probing pocket depth (PPD) and mean peri-implant bleeding on probing (BOP); secondary outcomes included disease resolution (composite treatment outcome: residual probing depths ≤ 5 mm; no BOP in one or more probing site; no suppuration on probing), suppuration on probing (SOP) and radiographic marginal bone levels (MBLs), evaluated 3, 6, 9 and 12 months postoperatively (T3, T6, T9, T12). Linear and logistic mixed-effects models were employed.RESULTSBetween-group analyses showed that BOP was significantly lower in the test group compared to the control group at T9 (β = -10.57%, 95% CI: -20.17 to -0.97, p = 0.03) and T12 (β = -14.47%, 95% CI: -25.9 to -3.04, p = 0.01). No other parameters in the mixed-effects models showed statistically significant differences between groups at any timepoint.CONCLUSIONAccess-flap peri-implantitis surgery supplemented with systemic amoxicillin and metronidazole led to a statistically significant reduction in peri-implant BOP after 1 year, whereas no other parameters showed statistically significant differences between groups at any timepoint. The clinical implications of these differences should be interpreted with caution, as the isolated short-term effect does not translate into broader or sustained clinical benefit and must be weighed against the risks associated with systemic antibiotic use.
{"title":"Adjunctive Systemic Amoxicillin and Metronidazole Following Surgical Peri-Implantitis Treatment: A Single-Blind Randomised Controlled Trial With a 1-Year Follow-Up.","authors":"Jarno Hakkers,Yvonne C M de Waal,Barzi Gareb,Henny J A Meijer,Gerry M Raghoebar","doi":"10.1111/jcpe.70100","DOIUrl":"https://doi.org/10.1111/jcpe.70100","url":null,"abstract":"AIMTo analyse the effect of systemic amoxicillin and metronidazole on surgical peri-implantitis treatment with a follow-up period of 1 year.MATERIALS AND METHODSFifty-nine patients were randomly assigned to receive peri-implantitis surgery supplemented with (29 patients; test) or without (30 patients; control) systemic amoxicillin and metronidazole, in cases with no, one-wall or two-wall bony defects. Primary outcomes were mean peri-implant probing pocket depth (PPD) and mean peri-implant bleeding on probing (BOP); secondary outcomes included disease resolution (composite treatment outcome: residual probing depths ≤ 5 mm; no BOP in one or more probing site; no suppuration on probing), suppuration on probing (SOP) and radiographic marginal bone levels (MBLs), evaluated 3, 6, 9 and 12 months postoperatively (T3, T6, T9, T12). Linear and logistic mixed-effects models were employed.RESULTSBetween-group analyses showed that BOP was significantly lower in the test group compared to the control group at T9 (β = -10.57%, 95% CI: -20.17 to -0.97, p = 0.03) and T12 (β = -14.47%, 95% CI: -25.9 to -3.04, p = 0.01). No other parameters in the mixed-effects models showed statistically significant differences between groups at any timepoint.CONCLUSIONAccess-flap peri-implantitis surgery supplemented with systemic amoxicillin and metronidazole led to a statistically significant reduction in peri-implant BOP after 1 year, whereas no other parameters showed statistically significant differences between groups at any timepoint. The clinical implications of these differences should be interpreted with caution, as the isolated short-term effect does not translate into broader or sustained clinical benefit and must be weighed against the risks associated with systemic antibiotic use.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"3 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145961602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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