Beyond traditional translation: ncRNA derived peptides as modulators of tumor behaviors.

IF 9 2区 医学 Q1 CELL BIOLOGY Journal of Biomedical Science Pub Date : 2024-06-14 DOI:10.1186/s12929-024-01047-0
Kang Wen, Xin Chen, Jingyao Gu, Zhenyao Chen, Zhaoxia Wang
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Abstract

Within the intricate tapestry of molecular research, noncoding RNAs (ncRNAs) were historically overshadowed by a pervasive presumption of their inability to encode proteins or peptides. However, groundbreaking revelations have challenged this notion, unveiling select ncRNAs that surprisingly encode peptides specifically those nearing a succinct 100 amino acids. At the forefront of this epiphany stand lncRNAs and circRNAs, distinctively characterized by their embedded small open reading frames (sORFs). Increasing evidence has revealed different functions and mechanisms of peptides/proteins encoded by ncRNAs in cancer, including promotion or inhibition of cancer cell proliferation, cellular metabolism (glucose metabolism and lipid metabolism), and promotion or concerted metastasis of cancer cells. The discoveries not only accentuate the depth of ncRNA functionality but also open novel avenues for oncological research and therapeutic innovations. The main difficulties in the study of these ncRNA-derived peptides hinge crucially on precise peptide detection and sORFs identification. Here, we illuminate cutting-edge methodologies, essential instrumentation, and dedicated databases tailored for unearthing sORFs and peptides. In addition, we also conclude the potential of clinical applications in cancer therapy.

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超越传统翻译:作为肿瘤行为调节剂的 ncRNA 衍生肽。
在错综复杂的分子研究中,非编码 RNA(ncRNA)一直被普遍认为不能编码蛋白质或肽而蒙上阴影。然而,突破性的发现对这一观点提出了挑战,揭示出某些 ncRNA 竟然能编码肽,特别是那些接近 100 个氨基酸的肽。lncRNA和circRNA是这一顿悟的前沿,它们的显著特征是内嵌小开放阅读框(sORF)。越来越多的证据显示,由 ncRNAs 编码的肽/蛋白在癌症中具有不同的功能和机制,包括促进或抑制癌细胞增殖、细胞代谢(葡萄糖代谢和脂质代谢)以及促进或协同癌细胞转移。这些发现不仅凸显了 ncRNA 功能的深度,还为肿瘤研究和治疗创新开辟了新途径。研究这些 ncRNA 衍生多肽的主要困难在于精确的多肽检测和 sORFs 识别。在此,我们阐述了为发现 sORF 和多肽而量身定制的前沿方法、基本仪器和专用数据库。此外,我们还总结了癌症治疗的临床应用潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Biomedical Science
Journal of Biomedical Science 医学-医学:研究与实验
CiteScore
18.50
自引率
0.90%
发文量
95
审稿时长
1 months
期刊介绍: The Journal of Biomedical Science is an open access, peer-reviewed journal that focuses on fundamental and molecular aspects of basic medical sciences. It emphasizes molecular studies of biomedical problems and mechanisms. The National Science and Technology Council (NSTC), Taiwan supports the journal and covers the publication costs for accepted articles. The journal aims to provide an international platform for interdisciplinary discussions and contribute to the advancement of medicine. It benefits both readers and authors by accelerating the dissemination of research information and providing maximum access to scholarly communication. All articles published in the Journal of Biomedical Science are included in various databases such as Biological Abstracts, BIOSIS, CABI, CAS, Citebase, Current contents, DOAJ, Embase, EmBiology, and Global Health, among others.
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