Feasibility of a randomized, sham-controlled pilot study for accelerated rTMS-treatment of the cerebellum plus physiotherapy in CANVAS patients.

IF 1.7 4区医学 Q3 CLINICAL NEUROLOGY NeuroRehabilitation Pub Date : 2024-01-01 DOI:10.3233/NRE-240045

Marcus Grobe-Einsler, Friederike Bork, Aline Faikus, Sebastiaan F W Neggers, Oliver Kaut

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Abstract

Background: Cerebellar ataxia, neuropathy and bilateral vestibular areflexia (CANVAS) is a rare neurodegenerative disease affecting the cerebellum, the peripheral nervous system and the vestibular system. Due to the lack of approved drugs, therapy comprises physiotherapy and speech therapy. Transcranial magnetic stimulation is a promising non-invasive therapeutic option to complement classical symptomatic therapies.

Objective: To test feasibility of the combination of transcranial magnetic stimulation using an accelerated protocol and standard symptomatic therapy in patients with CANVAS.

Methods: Eight patients with genetically confirmed CANVAS were assigned to either verum or sham cerebellar transcranial magnetic stimulation using an accelerated protocol. Treatment duration was limited to 5 days. Additionally, patients in both groups received symptomatic therapy (speech and physiotherapy) for the duration of the study.

Results: All patients completed the stimulation protocol. Adverse events were rare. Ataxia severity improved in the verum group only.

Conclusion: The combination of transcranial magnetic stimulation and classic symptomatic therapy is feasible in a neuro-rehabilitation setting and potentially ameliorates ataxia severity.

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对 CANVAS 患者进行小脑加速经颅磁刺激治疗加物理治疗的随机假对照试验研究的可行性。

背景：小脑共济失调、神经病变和双侧前庭反射障碍（CANVAS）是一种罕见的神经退行性疾病，影响小脑、周围神经系统和前庭系统。由于缺乏经批准的药物，治疗方法包括物理疗法和语言疗法。经颅磁刺激是一种很有前景的非侵入性疗法，可作为传统对症疗法的补充：目的：测试在 CANVAS 患者中采用加速方案将经颅磁刺激与标准对症疗法相结合的可行性：方法：8 名经基因确诊的 CANVAS 患者被分配接受采用加速方案的 verum 或假小脑经颅磁刺激治疗。治疗时间限制为 5 天。此外，两组患者在研究期间都接受了对症治疗（语言和物理治疗）：所有患者都完成了刺激方案。不良事件很少发生。结果：所有患者都完成了刺激方案，不良事件很少发生，只有verum组的共济失调严重程度有所改善：结论：经颅磁刺激与传统对症疗法的结合在神经康复治疗中是可行的，并有可能改善共济失调的严重程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NeuroRehabilitation CLINICAL NEUROLOGY-REHABILITATION

CiteScore

3.20

自引率

0.00%

发文量

178

审稿时长

6-12 weeks

期刊介绍： NeuroRehabilitation, an international, interdisciplinary, peer-reviewed journal, publishes manuscripts focused on scientifically based, practical information relevant to all aspects of neurologic rehabilitation. We publish unsolicited papers detailing original work/research that covers the full life span and range of neurological disabilities including stroke, spinal cord injury, traumatic brain injury, neuromuscular disease and other neurological disorders. We also publish thematically organized issues that focus on specific clinical disorders, types of therapy and age groups. Proposals for thematic issues and suggestions for issue editors are welcomed.