Repeated measurement of antibody for COVID-19 evoked having common variable immunodeficiency (CVID): Case report

Medical Reports Pub Date : 2024-06-11 DOI:10.1016/j.hmedic.2024.100082

Haruna Yamaki , Yoshihiro Miyashita , Shunya Hanawa , Shuichiro Ide , Makoto Kawaguchi , Hiroaki Kobayashi , Toshiharu Tsutsui , Yumiko Kakizaki , Yosuke Hirotsu , Masao Omata , Tomohiro Morio , Yasunari Miyazaki

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Abstract

A 43-year-old female who was diagnosed with coronavirus disease 2019 (COVID-19) seventeen days before was transferred to our hospital because of fever and cough.Computed tomography (CT) showed consolidations in both lung fields, and we diagnosed COVID-19 pneumonia. After the addition of remdesivir and baricitinib, her symptoms improved. However, on day 19 a fever was observed, and CT also showed new consolidations. Genomic analysis revealed a different type from the first infection.Furthermore, repeated measurement of antibodies against SARS-CoV-2 revealed no antibody production. She was diagnosed with immunodeficiency and recovered completely with the use of immunoglobulins and antibody preparations for COVID-19. We report that repeated measurement of antibodies against SARS-CoV-2 revealed immunodeficiency disease.

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重复测量 COVID-19 抗体诱发常见变异性免疫缺陷症 (CVID)：病例报告

一名43岁的女性患者在17天前被诊断为冠状病毒病2019（COVID-19），因发烧和咳嗽转入我院。计算机断层扫描（CT）显示她的双肺野出现合并症，我们诊断她患上了COVID-19肺炎。在服用雷米替韦和巴利替尼后，她的症状有所改善。然而，在第19天，她出现了发烧症状，CT也显示出了新的合并症。基因组分析表明，该病毒与第一次感染的类型不同。此外，反复测量 SARS-CoV-2 抗体后发现没有抗体产生。她被诊断为免疫缺陷，使用免疫球蛋白和 COVID-19 抗体制剂后完全康复。我们报告说，重复测量 SARS-CoV-2 抗体发现了免疫缺陷病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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