Sesamol Alleviates Sarcopenia via Activating AKT/mTOR/FoxO1 Signal Pathway in Aged Obese Mice.

IF 3.1 2区 农林科学 Q2 CHEMISTRY, APPLIED Plant Foods for Human Nutrition Pub Date : 2024-09-01 Epub Date: 2024-06-15 DOI:10.1007/s11130-024-01199-2
Jinxin Yang, Zhipeng Wang, Yan Xie, Yongyan Tang, Yansong Fu, Zhuoya Xu, Jingmiao Chen, Hong Qin
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Abstract

Sesamol is a major bioactive component extracted from sesame seeds and has various medicinal properties. However, the effects of sesamol on sarcopenia associated with aging and obesity remains unclear. Therefore, the protective effects and underlying mechanisms of sesamol on sarcopenia was evaluated in aged and obese C57BL/6 J male mouse models fed a high fat diet and C2C12 myotubes co-treated with D-gal and PA in this study. Our in vivo data showed that sesamol activated AKT/mTOR/FoxO1 signal pathway, and then upregulated p-p70S6K and p-4EBP1 to promote myoprotein synthesis, and downregulated Atrogin-1 and MuRF1 to inhibit myoprotein degradation, thus ameliorating sarcopenia related to aging and obesity. Furthermore, our in vitro results confirmed the protective effect and aforementioned mechanisms of sesamol on sarcopenia. Collectively, sesamol could alleviate sarcopenia associated with aging and obesity via activating the AKT/mTOR/FoxO1 signal pathway. Our findings highlight the therapeutic potentials of sesamol for aging and obesity-related metabolic muscular complications.

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芝麻酚通过激活 AKT/mTOR/FoxO1 信号通路缓解老年肥胖症小鼠的肌肉疏松症
芝麻酚是从芝麻中提取的一种主要生物活性成分,具有多种药用功效。然而,芝麻酚对与衰老和肥胖相关的肌肉疏松症的影响仍不清楚。因此,本研究评估了芝麻酚对以高脂饮食喂养的老年肥胖 C57BL/6 J 雄性小鼠模型和以 D-gal 和 PA 联合处理的 C2C12 肌细胞管肌肉疏松症的保护作用及其内在机制。体内数据显示,芝麻酚可激活 AKT/mTOR/FoxO1 信号通路,进而上调 p-p70S6K 和 p-4EBP1 以促进肌蛋白合成,下调 Atrogin-1 和 MuRF1 以抑制肌蛋白降解,从而改善与衰老和肥胖相关的肌肉疏松症。此外,我们的体外研究结果证实了芝麻酚对肌肉疏松症的保护作用和上述机制。总之,芝麻酚可通过激活AKT/mTOR/FoxO1信号通路,缓解与衰老和肥胖相关的肌肉疏松症。我们的研究结果凸显了芝麻酚对衰老和肥胖相关的代谢性肌肉并发症的治疗潜力。
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来源期刊
Plant Foods for Human Nutrition
Plant Foods for Human Nutrition 工程技术-食品科技
CiteScore
6.80
自引率
7.50%
发文量
89
审稿时长
12-24 weeks
期刊介绍: Plant Foods for Human Nutrition (previously Qualitas Plantarum) is an international journal that publishes reports of original research and critical reviews concerned with the improvement and evaluation of the nutritional quality of plant foods for humans, as they are influenced by: - Biotechnology (all fields, including molecular biology and genetic engineering) - Food science and technology - Functional, nutraceutical or pharma foods - Other nutrients and non-nutrients inherent in plant foods
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