Medication non-adherence among outpatients with myocardial infarction: A hospital-based study

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Clinical Epidemiology and Global Health Pub Date : 2024-06-13 DOI:10.1016/j.cegh.2024.101682

Anan S. Jarab , Razan Z. Mansour , Suhaib Muflih , Walid Al-Qerem , Shrouq R. Abu Heshmeh , Tareq Mukattash , Yazid N. Al Hamarneh , Maher Khdour

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Abstract

Background

Despite the availability of effective medications for the treatment of myocardial infarction (MI), treatment outcomes are suboptimal due to medication non-adherence. The aim of this study was to assess medication adherence and its associated factors among patients with MI.

Methods

This cross-sectional study was conducted on outpatients with MI in the cardiology clinic at a major hospital in Jordan. Medication adherence was assessed using the validated Arabic version of the 4-item Medication Adherence Scale. Ordinal regression was conducted to identify the variables associated with medication non-adherence.

Results

A total of 333 patients participated in the study. The median age was 58 years (57–60). Medication non-adherence was expressed by 54.6 % of the participants. Having less than college/university education (Coefficient = −0.625, 95%Cl (−1.191 to −0.06), P = 0.03) and increased medication-related concerns (Coefficient = −0.065, 95 % Cl (−0.126 to −0.003), P = 0.04) were associated with decreased medication adherence. Other factors, including having no family history of cardiovascular disease (CVD) (Coefficient = 0.757, 95%Cl (0.218–1.295), P = 0.006) and increased medication necessity (Coefficient = 0.186, 95%Cl (0.133–0.239), P < 0.001) were associated with high medication adherence.

Conclusion

The current study demonstrated a high rate of medication non-adherence in MI patients, necessitating the need to develop tailored pharmaceutical care interventions that address patients' medication-related beliefs, focusing on their perceptions of medication necessity and concerns, particularly in patients with low education level and those with a positive family history of CVD.

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心肌梗死门诊患者不遵医嘱用药的情况：一项基于医院的研究

背景尽管目前有治疗心肌梗死（MI）的有效药物，但由于不遵医嘱用药，治疗效果并不理想。本研究旨在评估心肌梗死患者的用药依从性及其相关因素。方法本横断面研究针对约旦一家大型医院心脏病诊所的心肌梗死门诊患者。采用经验证的阿拉伯语版 4 项用药依从性量表对用药依从性进行评估。结果共有 333 名患者参与了研究。中位年龄为 58 岁（57-60 岁）。54.6%的参与者表示不遵医嘱用药。受教育程度低于大专/大学（系数 = -0.625，95%Cl (-1.191 to -0.06)，P = 0.03）和用药相关担忧增加（系数 = -0.065，95 % Cl (-0.126 to -0.003)，P = 0.04）与用药依从性下降有关。其他因素，包括无心血管疾病（CVD）家族史（系数 = 0.757，95%Cl (0.218-1.295)，P = 0.006）和用药必要性增加（系数 = 0.186，95%Cl (0.133-0.239)，P < 0.001）与用药依从性高相关。结论目前的研究表明，心肌梗死患者的用药不依从率很高，因此有必要针对患者的用药相关信念制定有针对性的药物护理干预措施，重点关注他们对用药必要性的看法和顾虑，尤其是教育水平低的患者和有阳性心血管疾病家族史的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.60

自引率

7.70%

发文量

218

审稿时长

66 days

期刊介绍： Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.