Diabetes distress and depression are independently associated with gastrointestinal symptoms in type 2 diabetes in Bangladesh

IF 3.2 3区医学 Q2 ENDOCRINOLOGY & METABOLISM Diabetic Medicine Pub Date : 2024-06-17 DOI:10.1111/dme.15379

M. Kamruzzaman, M. Horowitz, W. H. Polonsky, N. J. Talley, M. A. Borg, C. K. Rayner, K. L. Jones, C. S. Marathe

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Abstract

Background and Aims

Gastrointestinal (GI) symptoms, common in type 2 diabetes (T2D), are typically bothersome, socially embarrassing, and impact negatively on quality of life. They may also contribute to diabetes distress (DD), but this has never been formally evaluated. We aimed to investigate the relationships between GI symptoms, DD and depressive symptoms in a large cohort of individuals with T2D in Bangladesh.

Materials and Methods

1406 unselected T2D individuals (female 58.8%; mean age 51.0 ± 12.5 years) from four diabetes clinics in Bangladesh completed validated questionnaires evaluating GI symptoms (PAGI-SYM), DD (DDS-17) and depressive symptoms (PHQ-9).

Results

31.1% of participants reported GI symptoms (36.2% females, 23.7% males), while 51.1% had elevated DD and 37.8% depressive symptoms. GI symptoms exhibited independent relationships with both DD and depressive symptoms, and their likelihood was higher among those with DD (OR: 3.6 [2.2–5.6] and with depressive symptoms (OR: 5.9 [3.5–9.9]).

Conclusions

GI symptoms are independently associated with both DD and depressive symptoms in people with T2D in Bangladesh.

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在孟加拉国，糖尿病困扰和抑郁与 2 型糖尿病患者的胃肠道症状密切相关。

背景和目的：胃肠道（GI）症状是 2 型糖尿病（T2D）的常见症状，通常令人烦恼、在社交场合令人尴尬，并对生活质量产生负面影响。胃肠道症状还可能导致糖尿病困扰（DD），但这一点尚未得到正式评估。材料和方法：来自孟加拉国四家糖尿病诊所的1406名未入选的 T2D 患者（女性占 58.8%；平均年龄为 51.0 ± 12.5 岁）填写了评估 GI 症状（PAGI-SYM）、DD（DDS-17）和抑郁症状（PHQ-9）的有效问卷：31.1%的参与者报告了胃肠道症状（女性占 36.2%，男性占 23.7%），51.1%的参与者有 DD 升高症状，37.8%的参与者有抑郁症状。胃肠道症状与腹泻和抑郁症状均有独立关系，且腹泻患者出现胃肠道症状的可能性更高（OR：3.6 [2.2-5.6]），抑郁症状患者出现胃肠道症状的可能性更高（OR：5.9 [3.5-9.9]）：结论：消化道症状与孟加拉国 T2D 患者的腹泻和抑郁症状密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetic Medicine 医学-内分泌学与代谢

CiteScore

7.20

自引率

5.70%

发文量

229

审稿时长

3-6 weeks

期刊介绍： Diabetic Medicine, the official journal of Diabetes UK, is published monthly simultaneously, in print and online editions. The journal publishes a range of key information on all clinical aspects of diabetes mellitus, ranging from human genetic studies through clinical physiology and trials to diabetes epidemiology. We do not publish original animal or cell culture studies unless they are part of a study of clinical diabetes involving humans. Categories of publication include research articles, reviews, editorials, commentaries, and correspondence. All material is peer-reviewed. We aim to disseminate knowledge about diabetes research with the goal of improving the management of people with diabetes. The journal therefore seeks to provide a forum for the exchange of ideas between clinicians and researchers worldwide. Topics covered are of importance to all healthcare professionals working with people with diabetes, whether in primary care or specialist services. Surplus generated from the sale of Diabetic Medicine is used by Diabetes UK to know diabetes better and fight diabetes more effectively on behalf of all people affected by and at risk of diabetes as well as their families and carers.”