Subcutaneous edema as a potential cause of catheter failure in older inpatients receiving peripheral parenteral nutrition.

IF 1.9 Q3 PHARMACOLOGY & PHARMACY Drug Discoveries and Therapeutics Pub Date : 2024-07-09 Epub Date: 2024-06-15 DOI:10.5582/ddt.2024.01029
Motoko Kitada, Shigeo Yamamura, Etsuro Hori
{"title":"Subcutaneous edema as a potential cause of catheter failure in older inpatients receiving peripheral parenteral nutrition.","authors":"Motoko Kitada, Shigeo Yamamura, Etsuro Hori","doi":"10.5582/ddt.2024.01029","DOIUrl":null,"url":null,"abstract":"<p><p>Malnutrition is a common problem among hospitalized older patients. Peripheral parenteral nutrition (PN) can improve patient outcomes but can also lead to complications that affect future treatment. Older inpatients, in particular, are expected to be prone to these catheter-related complications. However, the impact of peripheral PN on older inpatients has been rarely investigated. In the current study, the impact of PN on short peripheral catheters (SPCs) was evaluated by comparing signs and symptoms at the time of catheter removal between 22 patients with PN and 27 without. In addition to external clinical assessment, sonographic investigations of the SPC site were performed. The prevalence of external signs and symptoms of complications was similar between the patients (all P > 0.05). However, subcutaneous edema was found by ultrasound in > 80% of patients with PN, compared with 55.6% of those without PN (P = 0.051). Unlike cases without PN, all patients with PN who presented with external signs and symptoms developed subcutaneous edema (P = 0.022). Multivariate analysis demonstrated that administration of PN was independently associated with subcutaneous edema (adjusted odds ratio = 6.88, 95% confidence interval = 1.083-75.486, P = 0.040). For several decades, phlebitis has been the primary focus of complications related to peripheral PN in clinical settings. However, our results imply that peripheral PN causes subcutaneous edema, which can lead to catheter failure in older inpatients. This study contributes to understanding the etiology of catheter failure during peripheral PN in this population.</p>","PeriodicalId":47494,"journal":{"name":"Drug Discoveries and Therapeutics","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Discoveries and Therapeutics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5582/ddt.2024.01029","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/15 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0

Abstract

Malnutrition is a common problem among hospitalized older patients. Peripheral parenteral nutrition (PN) can improve patient outcomes but can also lead to complications that affect future treatment. Older inpatients, in particular, are expected to be prone to these catheter-related complications. However, the impact of peripheral PN on older inpatients has been rarely investigated. In the current study, the impact of PN on short peripheral catheters (SPCs) was evaluated by comparing signs and symptoms at the time of catheter removal between 22 patients with PN and 27 without. In addition to external clinical assessment, sonographic investigations of the SPC site were performed. The prevalence of external signs and symptoms of complications was similar between the patients (all P > 0.05). However, subcutaneous edema was found by ultrasound in > 80% of patients with PN, compared with 55.6% of those without PN (P = 0.051). Unlike cases without PN, all patients with PN who presented with external signs and symptoms developed subcutaneous edema (P = 0.022). Multivariate analysis demonstrated that administration of PN was independently associated with subcutaneous edema (adjusted odds ratio = 6.88, 95% confidence interval = 1.083-75.486, P = 0.040). For several decades, phlebitis has been the primary focus of complications related to peripheral PN in clinical settings. However, our results imply that peripheral PN causes subcutaneous edema, which can lead to catheter failure in older inpatients. This study contributes to understanding the etiology of catheter failure during peripheral PN in this population.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
皮下水肿是导致接受外周肠外营养的老年住院患者导管失效的潜在原因。
营养不良是住院老年患者的常见问题。外周肠外营养(PN)可以改善患者的预后,但也可能导致影响未来治疗的并发症。老年住院患者尤其容易出现这些与导管相关的并发症。然而,外周 PN 对老年住院患者的影响却鲜有研究。在当前的研究中,通过比较 22 名有 PN 患者和 27 名无 PN 患者拔除导管时的体征和症状,评估了 PN 对短外周导管 (SPC) 的影响。除外部临床评估外,还对 SPC部位进行了超声检查。不同患者的并发症外部体征和症状发生率相似(均为 P > 0.05)。然而,超声波检查发现皮下水肿的 PN 患者超过 80%,而无 PN 患者为 55.6%(P = 0.051)。与无 PN 的病例不同,所有出现外部症状和体征的 PN 患者都出现了皮下水肿(P = 0.022)。多变量分析表明,使用 PN 与皮下水肿密切相关(调整赔率 = 6.88,95% 置信区间 = 1.083-75.486,P = 0.040)。几十年来,静脉炎一直是临床上外周静脉输液并发症的主要病因。然而,我们的研究结果表明,外周静脉输液会引起皮下水肿,从而导致老年住院患者导管失效。这项研究有助于了解老年患者外周静脉输液过程中导管失效的病因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Drug Discoveries and Therapeutics
Drug Discoveries and Therapeutics PHARMACOLOGY & PHARMACY-
CiteScore
3.20
自引率
3.20%
发文量
51
期刊最新文献
A stroke patient with persistently intermittent fever treated with gabapentin: A clinical case. Effect of switching from dulaglutide to tirzepatide on blood glucose and renal function. Novel and emerging therapeutics for antimicrobial resistance: A brief review. Padding the seat of a wheelchair reduces ischial pressure and improves sitting comfort. Mitotic abnormalities and spindle assembly checkpoint inactivation in a cell model of Shwachman-Diamond syndrome with mutations in the Shwachman-Bodian-Diamond syndrome gene, 258+2T > C.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1