Resistance Exercise Reduces Sarcopenia by Repairing Leaky Gut in Patients With Alzheimer's Disease

IF 4.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Archives of Medical Research Pub Date : 2024-06-16 DOI:10.1016/j.arcmed.2024.103025
Rizwan Qaisar , M. Shahid Iqbal , Asima Karim , Firdos Ahmad
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Abstract

Purpose

Sarcopenia or age-associated muscle loss is common in patients with Alzheimer's disease (AD). We have previously demonstrated the contribution of a leaky gut to sarcopenia in AD. Here, we asked whether resistant exercise (RE) reduces the sarcopenia phenotype by repairing intestinal leakage in patients with AD.

Method

A prospective, single-center study of older adults, including healthy controls and patients with AD (n = 44–51/group), was conducted to measure plasma zonulin and claudin-3 (markers of intestinal leakage), handgrip strength (HGS), and short physical performance battery (SPPB) as a measure of functional capacity. Measurements in patients with AD were performed at baseline and after 12 weeks of RE.

Results

At baseline, patients with AD had higher plasma zonulin and claudin-3 and lower HGS, gait speed, and SPPB scores than controls. RE reduced plasma zonulin and claudin-3 levels and improved HGS, SPPB scores, and gait speed. Regression analysis revealed robust relationships between changes in plasma zonulin and claudin-3 with HGS. Plasma zonulin was also positively associated with SPPB scores. In addition, RE downregulated plasma markers of inflammation and oxidative stress. However, the prevalence of sarcopenia based on low HGS and muscle atrophy or low SPPB was not affected by RE.

Conclusion

Taken together, disruption of the intestinal mucosal barrier may contribute to functional decline and sarcopenia in AD, which is incompletely recovered by RE. Circulating levels of zonulin and claudin-3 may be valuable in predicting sarcopenia and functional capacity in older adults with AD.

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阻力运动通过修复阿尔茨海默病患者的肠道渗漏,减少肌肉疏松症的发生
目的:在阿尔茨海默病(AD)患者中,肌肉疏松症或与年龄相关的肌肉流失很常见。我们以前曾证实,肠道渗漏是导致阿兹海默症患者肌肉疏松症的原因之一。在此,我们想知道抗阻力运动(RE)是否能通过修复 AD 患者的肠道渗漏来减少肌肉疏松症表型:方法:我们对包括健康对照组和 AD 患者(44-51 人/组)在内的老年人进行了一项前瞻性单中心研究,以测量血浆 zonulin 和 claudin-3(肠道渗漏的标志物)、手握强度(HGS)以及作为功能能力测量指标的短期体能测试(SPPB)。对注意力缺失症患者的测量在基线和 RE 12 周后进行:与对照组相比,基线时 AD 患者的血浆 zonulin 和 claudin-3 较高,HGS、步速和 SPPB 分数较低。RE降低了血浆zonulin和claudin-3水平,改善了HGS、SPPB评分和步速。回归分析显示,血浆zonulin和claudin-3的变化与HGS之间存在密切关系。血浆zonulin还与SPPB评分呈正相关。此外,RE 下调了血浆中的炎症和氧化应激标记物。然而,RE 对基于低 HGS 和肌肉萎缩或低 SPPB 的肌少症发病率没有影响:综上所述,肠粘膜屏障的破坏可能会导致AD患者的功能衰退和肌少症,而RE又不能完全恢复这种功能衰退和肌少症。循环中的zonulin和claudin-3水平可能对预测患有AD的老年人的肌少症和功能能力有价值。
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来源期刊
Archives of Medical Research
Archives of Medical Research 医学-医学:研究与实验
CiteScore
12.50
自引率
0.00%
发文量
84
审稿时长
28 days
期刊介绍: Archives of Medical Research serves as a platform for publishing original peer-reviewed medical research, aiming to bridge gaps created by medical specialization. The journal covers three main categories - biomedical, clinical, and epidemiological contributions, along with review articles and preliminary communications. With an international scope, it presents the study of diseases from diverse perspectives, offering the medical community original investigations ranging from molecular biology to clinical epidemiology in a single publication.
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