Vis-SPLIT: Interactive Hierarchical Modeling for mRNA Expression Classification.

Braden Roper, James C Mathews, Saad Nadeem, Ji Hwan Park
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Abstract

We propose an interactive visual analytics tool, Vis-SPLIT, for partitioning a population of individuals into groups with similar gene signatures. Vis-SPLIT allows users to interactively explore a dataset and exploit visual separations to build a classification model for specific cancers. The visualization components reveal gene expression and correlation to assist specific partitioning decisions, while also providing overviews for the decision model and clustered genetic signatures. We demonstrate the effectiveness of our framework through a case study and evaluate its usability with domain experts. Our results show that Vis-SPLIT can classify patients based on their genetic signatures to effectively gain insights into RNA sequencing data, as compared to an existing classification system.

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Vis-SPLIT:用于 mRNA 表达分类的交互式分层建模。
我们提出了一种交互式可视化分析工具 Vis-SPLIT,用于将个体群体划分为具有相似基因特征的群体。Vis-SPLIT 允许用户交互式地探索数据集,并利用可视化分离建立特定癌症的分类模型。可视化组件揭示了基因表达和相关性,以协助特定的分区决策,同时还提供了决策模型和聚类基因特征的概览。我们通过案例研究证明了我们框架的有效性,并与领域专家一起评估了其可用性。结果表明,与现有的分类系统相比,Vis-SPLIT 可以根据基因特征对患者进行分类,从而有效地深入了解 RNA 测序数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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Vis-SPLIT: Interactive Hierarchical Modeling for mRNA Expression Classification.
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