A study on Hematological and Biochemical Parameters of Dengue Fever Patients in Janakpurdham, Madhesh Province, Nepal

Abstract

Background: Over 350 million people are estimated to get the counter with flavivirus each year, causing dengue one of the most common arboviral diseases. Following the COVID-19 outbreak, there has been a recorded rise in the prevalence of dengue fever in the South Asian countries. In 2022, there was a significant dengue outbreak in Nepal. Data on haematological and biochemical parameters, which are crucial for the clinical management of dengue patients, are lacking in Nepal's Madhesh Province. The purpose of this study was to present the first baseline data on the haematological and biochemical parameters of dengue virus-infected patients. Methods: The data was extracted from admitted patients at Janaki Medical College, Teaching Hospital (JMCTH) and Janaki Health Care and Teaching Hospital (JHCTH) diagnosed with dengue fever between August to November-2023. Hematological and biochemical parameters were recorded from the medical records and analyzed. Results: There were 74 serologically positive dengue cases in all, with 32.4% being female and 67.6% being male. Of the 74 patients, one-fourth had NS1 positive, 24.3% had IgM, and 21.6% had IgG. Leucopenia (87.2%) and thrombocytopenia (66.2%) were the most frequent haematological findings, whereas serum glutamic-oxaloacetate transaminase (76.6%) and Serum glutamic pyruvic transaminase (58.1%) were the biochemical markers with higher levels. Conclusion: The study explores the most common haematological and biochemical parameters of the patients diagnosed with dengue that may alarm clinicians of the possibility of dengue virus infection in the study region.