ATP as a signaling molecule

L. G. Babich, S. G. Shlykov, S. O. Kosterin
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Abstract

The review considers the effects of extracellular ATP mediated by plasma membrane purinoreceptors in the cells of different tissues, in particular, myometrium. Recently published results suggest that cytosolic ATP may also play a role of signaling molecule, as indicated by the detection of the ATP receptor not only in the plasma membrane, but also in mitochondria. The authors have shown that ionized Ca2+ concentration in the rat myometrium mitochondria matrix is regulated by ATP at the absence of exogenous Ca2+. ATP concentration-dependent increase of [Ca2+]m was not affected in the presence of the mitochondrial Ca2+-uniporter blocker ruthenium red, the mitochondrial pore blocker cyclosporine A, or ATP synthase inhibitor oligomycin. It is assumed that cytosolic ATP could be a signaling molecule that regulates at least the Ca2+ ions exchange in mitochondria. Keywords: Ca2+ ions exchange, extracellular and cytosolic ATP, mitochondria, P2X7 receptors
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作为信号分子的 ATP
这篇综述探讨了细胞外 ATP 在不同组织细胞(尤其是子宫肌层)中由质膜嘌呤受体介导的作用。最近发表的研究结果表明,细胞质 ATP 也可能起到信号分子的作用,这不仅体现在质膜上,还体现在线粒体中检测到 ATP 受体。作者发现,在没有外源 Ca2+ 的情况下,大鼠子宫肌层线粒体基质中的电离 Ca2+ 浓度受 ATP 调节。在线粒体 Ca2+-uniporter 阻断剂钌红、线粒体孔阻断剂环孢素 A 或 ATP 合成酶抑制剂寡霉素存在的情况下,[Ca2+]m 的增加不受 ATP 浓度的影响。推测细胞质 ATP 可能是一种信号分子,至少能调节线粒体中的 Ca2+ 离子交换。关键词Ca2+离子交换 细胞外和细胞质ATP 线粒体 P2X7受体
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