Emerging roles for the RXFP1 in myeloid series leukemia

Abstract

Purpose: The study investigates the role of Relaxin Family Peptide Receptor 1 (RXFP1) in myeloid leukemia cell function. It found that RXFP1 has been associated with cAMP, PI3K/Akt, NO/cGMP, MAPK and ERK1/2 signaling. High RXFP1 expression was associated with shorter cancer-specific survival RXFP1 mutated leukemia patients. The study suggests that RXFP1 may promote invasion and progression in both types of AML and CML. Methods: The gene expression data were retrieved from Gene Expression Omnibus (GEO). Fold change, p.value t-test and David Functional analysis, hierarchical clustering was performed. Conclusion: PCDH9, AREG, CTSG, RXFP1, CCDC152, ANXA, CD24 and VPREB1 gene expression alterations were identified depending on leukemia in human moocyte cells. Seven of these genes were identified as downregulated in leukemia groups in human monocyte cells and one of these genes were identified as upregulated in leukemia cells.Therefore, it is hypothesized that downregulation or upregulation of these genes may affect AML/CML pathogenesis by reducing cell proliferation. And it is predicted that RXFP1 mutation may be an important factor for myeloid leukemia.