Significance of Ribonucleoside-diphosphate Reductase Subunit M2 in Lung Adenocarcinoma

IF 4.7 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-06-12 DOI:10.2174/0115665232286359240611051307
Xiao-Jun Wang, Yun-Xia Huo, Peng-Jun Yang, Jing Gao, Weipeng Hu
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Abstract

The Ribonucleoside-diphosphate Reductase subunit M2 (RRM2) is known to be overexpressed in various cancers, though its specific functional implications remain unclear. This aims to elucidate the role of RRM2 in the progression of Lung Adenocarcinoma (LUAD) by exploring its involvement and potential impact. RRM2 data were sourced from multiple databases to assess its diagnostic and prognostic significance in LUAD. We evaluated the association between RRM2 expression and immune cell infiltration, analyzed its function, and explored the effects of modulating RRM2 expression on LUAD cell characteristics through laboratory experiments.
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核糖核苷-二磷酸还原酶亚基 M2 在肺腺癌中的意义
众所周知,核糖核苷-二磷酸还原酶亚基M2(RRM2)在多种癌症中过度表达,但其具体功能影响仍不清楚。本文旨在通过探讨RRM2在肺腺癌(LUAD)进展过程中的参与和潜在影响,阐明RRM2在肺腺癌中的作用。我们通过实验室实验评估了RRM2表达与免疫细胞浸润之间的关联,分析了其功能,并探讨了调节RRM2表达对LUAD细胞特征的影响。
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来源期刊
CiteScore
7.20
自引率
4.30%
发文量
567
期刊介绍: ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric. Indexed/​Abstracted: Web of Science SCIE Scopus CAS INSPEC Portico
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