{"title":"Gender-Specific Effects of Alternate-Day Fasting on Body Weight, Oxidative Stress, and Metabolic Health in Middle-Aged Rats","authors":"Özgen Kılıç Erkek, G. Gündoğdu","doi":"10.31362/patd.1487708","DOIUrl":null,"url":null,"abstract":"Purpose: The purpose of this study was to assess the effect of alternate-day fasting (ADF) concerning sex as well as its function in systemic and tissue-level oxidative stress alterations associated with aging. \nMaterials and methods: Forty-two female (n=21) and male (n=21) Wistar rats (aged 16 months) were separated into six groups (n=7 each):Group-1 (control-male), Group-2 (1-month,ADF-male), Group-3 (2-month,ADF-male), Group-4 (control-female), Group-5 (1-month,ADF-female), and Group-6 (2-month,ADF-female). The ADF protocol was applied every other day for 24-h of fasting (three days/week). Serum samples were analyzed via ELISA to measure total oxidant-antioxidant status (TOS-TAS), and the oxidative stress index (OSI) was calculated. \nResults: 2-months of ADF treatment reduced body weight (BW) compared compliance control groups (P","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pamukkale Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31362/patd.1487708","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Purpose: The purpose of this study was to assess the effect of alternate-day fasting (ADF) concerning sex as well as its function in systemic and tissue-level oxidative stress alterations associated with aging.
Materials and methods: Forty-two female (n=21) and male (n=21) Wistar rats (aged 16 months) were separated into six groups (n=7 each):Group-1 (control-male), Group-2 (1-month,ADF-male), Group-3 (2-month,ADF-male), Group-4 (control-female), Group-5 (1-month,ADF-female), and Group-6 (2-month,ADF-female). The ADF protocol was applied every other day for 24-h of fasting (three days/week). Serum samples were analyzed via ELISA to measure total oxidant-antioxidant status (TOS-TAS), and the oxidative stress index (OSI) was calculated.
Results: 2-months of ADF treatment reduced body weight (BW) compared compliance control groups (P
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