A Comprehensive Review of L-Asparaginase: Production, Applications and Therapeutic Potential in Cancer Treatment

IF 1 4区 生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Applied Biochemistry and Microbiology Pub Date : 2024-06-10 DOI:10.1134/S0003683823602937
K. Hosseini, T. Zivari-Ghader, P. Akbarzadehlaleh, V. Ebrahimi, B. E. Sharafabad, A. Dilmaghani
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Abstract

L-Asparaginase (EC 3.5.1.1) primarily catalyzes the hydrolysis of Asn into ammonium and L-Asp and has wide applications in various industrial sectors. This protein has several sources, including microorganisms, plants, and the serum of certain rodents. Currently, L-asparaginase is primarily produced through biotechnology using bacteria and fungi. Genetic engineering methods are employed to create more stable enzymes than those available for the wild type. Given the extensive industrial use of L-asparaginase, optimization, and purification techniques are utilized to increase ex vivo enzyme production. The objective of this study is to comprehensively review the current literature on the production of L-asparaginase from diverse sources and using various methodologies.

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全面回顾 L-天冬酰胺酶:癌症治疗中的生产、应用和治疗潜力
L-Asparaginase (EC 3.5.1.1)主要催化 Asn水解成铵和 L-天冬酰胺,在各种工业领域有着广泛的应用。这种蛋白质有多种来源,包括微生物、植物和某些啮齿动物的血清。目前,L-天冬酰胺酶主要是利用细菌和真菌通过生物技术生产的。基因工程方法被用来制造比野生型更稳定的酶。鉴于 L-天冬酰胺酶在工业上的广泛应用,人们利用优化和纯化技术来提高体内外酶的产量。本研究的目的是全面回顾目前关于利用各种方法从不同来源生产 L-天冬酰胺酶的文献。
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来源期刊
Applied Biochemistry and Microbiology
Applied Biochemistry and Microbiology 生物-生物工程与应用微生物
CiteScore
1.70
自引率
12.50%
发文量
75
审稿时长
6-12 weeks
期刊介绍: Applied Biochemistry and Microbiology is an international peer reviewed journal that publishes original articles on biochemistry and microbiology that have or may have practical applications. The studies include: enzymes and mechanisms of enzymatic reactions, biosynthesis of low and high molecular physiologically active compounds; the studies of their structure and properties; biogenesis and pathways of their regulation; metabolism of producers of biologically active compounds, biocatalysis in organic synthesis, applied genetics of microorganisms, applied enzymology; protein and metabolic engineering, biochemical bases of phytoimmunity, applied aspects of biochemical and immunochemical analysis; biodegradation of xenobiotics; biosensors; biomedical research (without clinical studies). Along with experimental works, the journal publishes descriptions of novel research techniques and reviews on selected topics.
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