A Mn (II) Quinoline Complex (4QMn) Mitigates Oxidative Damage Induced by Ultraviolet Radiation and Protein Aggregation

IF 4.7 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-06-06 DOI:10.3390/cosmetics11030095

Marián Merino, Sonia González, M. Clares, Enrique García-España, J. Mullor

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Abstract

Solar radiation, specifically ultraviolet radiation (UVR), is one of the harmful external factors that affect the integrity of the skin upon sun overexposure. Its detrimental effects include skin aging (photoaging), pigmentation disorders, and skin cancer. Upon UVR exposure, a cascade of different cellular responses is initiated, giving rise to inflammatory processes, oxidative stress, protein misfolding, and DNA lesions, among other effects. Therefore, there is a growing need to explore and characterize new compounds for safeguarding the skin from solar radiation-induced damage. In this work, we analyze the antioxidant and anti-inflammatory capacities of the Mn (II) quinone complex (4QMn) in different cellular models and human skin explants. Importantly, our results suggest that 4QMn is able to ameliorate the oxidative damage produced by protein aggregation by reducing ROS levels, mitochondrial ROS (MitoROS), and DNA oxidative damage (8OH-dG) in a protein accumulation model. These findings suggest that the 4QMn compound could mitigate the deleterious effects of different sources of oxidative damage.

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一种锰 (II) 喹啉复合物 (4QMn) 可减轻紫外线辐射和蛋白质聚集引起的氧化损伤

太阳辐射，特别是紫外线辐射（UVR），是影响皮肤完整性的有害外部因素之一。其有害影响包括皮肤老化（光老化）、色素沉着病和皮肤癌。紫外线照射后，细胞会产生一连串不同的反应，引起炎症过程、氧化应激、蛋白质错误折叠和 DNA 损伤等。因此，人们越来越需要探索和鉴定新的化合物，以保护皮肤免受太阳辐射引起的损伤。在这项工作中，我们分析了锰（II）醌复合物（4QMn）在不同细胞模型和人体皮肤外植体中的抗氧化和抗炎能力。重要的是，我们的研究结果表明，在蛋白质聚集模型中，4QMn 能够通过降低 ROS 水平、线粒体 ROS（MitoROS）和 DNA 氧化损伤（8OH-dG）来改善蛋白质聚集产生的氧化损伤。这些研究结果表明，4QMn化合物可以减轻不同氧化损伤源的有害影响。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567

期刊介绍： ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric. Indexed/Abstracted： Web of Science SCIE Scopus CAS INSPEC Portico