Establishment of the benchmarking tool for evaluating the operation of biorepositories for pathogenic resource using a modified Delphi method

IF 3.5 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Biosafety and Health Pub Date : 2024-08-01 DOI:10.1016/j.bsheal.2024.05.001
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Abstract

In recent years, as the infectious diseases caused by pathogens such as novel coronavirus and mpox (formerly called monkeypox) spread globally, the significance of identification, preservation, and sharing of pathogenic resources become prominent. Along with the rapid development of biorepositories, it is imperative to evaluate their operation in a scientific manner. By using the literature review and modified Delphi method, this study develops a benchmarking tool for the comprehensive evaluation of the operation of biorepositories for pathogenic resources. The effective response rates of both rounds of expert surveys were 100 %. The authority coefficients (Cr) were 0.82 and 0.85, respectively, manifesting the reliability of consultation results. In the second-round survey, the Kendall’s coefficient of concordance (Kendall’s W) of all indicators ranged from 0.09 to 0.31 (P < 0.001), the comprehensive score ranged from 4.02 to 4.94, the standard deviation ranged from 0.21 to 0.77, and the coefficient of variation (CV) ranged from 0.04 to 0.22, indicating that the expert opinions reached consensus. The final benchmarking tool was composed of 4 primary indicators, 12 secondary indicators, and 65 tertiary indicators. The weights of the four primary indicators allocated through the rank-sum ratio method, namely organizational structure, management requirements, biobanking capacity, and sharing capacity, were 30.50 %, 30.08 %, 25.45 %, and 13.97 %, respectively. The benchmarking tool established in this study provides references for the comprehensive evaluation of the operation and puts forward advice for the sustainable development of biorepositories for pathogenic resources.

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利用改良德尔菲法建立病原体资源生物库运行评估基准工具
近年来,随着新型冠状病毒、痘(原称猴痘)等病原体引起的传染病在全球范围内蔓延,病原体资源的鉴定、保存和共享意义凸显。随着生物库的快速发展,对其运行情况进行科学评估势在必行。本研究通过文献综述和改良德尔菲法,开发了病原资源生物库运行综合评价的基准工具。两轮专家调查的有效回应率均为 100%。权威系数(Cr)分别为 0.82 和 0.85,体现了咨询结果的可靠性。在第二轮调查中,所有指标的肯德尔一致系数(Kendall's W)在 0.09 至 0.31 之间(P < 0.001),综合得分在 4.02 至 4.94 之间,标准差在 0.21 至 0.77 之间,变异系数(CV)在 0.04 至 0.22 之间,表明专家意见已达成一致。最终的基准工具由 4 个一级指标、12 个二级指标和 65 个三级指标组成。其中,组织结构、管理要求、生物银行能力和共享能力四个一级指标的权重分别为 30.50%、30.08%、25.45% 和 13.97%。本研究建立的标杆工具为病原资源生物库运行的综合评价提供了参考,为病原资源生物库的可持续发展提出了建议。
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来源期刊
Biosafety and Health
Biosafety and Health Medicine-Infectious Diseases
CiteScore
7.60
自引率
0.00%
发文量
116
审稿时长
66 days
期刊最新文献
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