{"title":"Could digoxin treat tachyarrhythmias in severe methylxanthine overdose?","authors":"Prinay Sohal , Michael E. Mullins","doi":"10.1016/j.mehy.2024.111408","DOIUrl":null,"url":null,"abstract":"<div><p>Caffeine and theophylline use can lead to methylxanthine toxicity, resulting in life-threatening tachyarrhythmias and hypotension. Esmolol, a beta-adrenergic antagonist, is a suggested option for controlling associated tachyarrhythmias. However, esmolol is not universally available, and its hypotensive effects often deter its use. Digoxin, another rate control agent which is widely available, theoretically possesses the circulatory system effects needed to tackle both tachyarrhythmia and hypotension induced by methylxanthine toxicity. We propose digoxin as an alternative to esmolol, especially in regions where esmolol is unavailable and for individuals experiencing hypotension due to methylxanthine toxicity.</p></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"189 ","pages":"Article 111408"},"PeriodicalIF":2.1000,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical hypotheses","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0306987724001518","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Caffeine and theophylline use can lead to methylxanthine toxicity, resulting in life-threatening tachyarrhythmias and hypotension. Esmolol, a beta-adrenergic antagonist, is a suggested option for controlling associated tachyarrhythmias. However, esmolol is not universally available, and its hypotensive effects often deter its use. Digoxin, another rate control agent which is widely available, theoretically possesses the circulatory system effects needed to tackle both tachyarrhythmia and hypotension induced by methylxanthine toxicity. We propose digoxin as an alternative to esmolol, especially in regions where esmolol is unavailable and for individuals experiencing hypotension due to methylxanthine toxicity.
期刊介绍：
Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.
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