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Hypothesis: Waterfowl may be important intermediary reservoirs of Naegleria fowleri
IF 2.1 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-12-01 DOI: 10.1016/j.mehy.2024.111541
Elise H. Mallon BS, Arnold Brown MD, FIDSA
Primary Amebic Meningoencephalitis (PAM) caused by Naegleria fowleri is a rare, usually fatal disease. It is thought that PAM occurs most often in southern US states because of the warmer surface waters in these states. To better understand the epidemiology of this disease we converted the raw number of cases reported in each state from 1962 to 2022, to an estimate of cases per individual at potential risk. Our relative risk estimates paint a slightly different picture, suggesting that in addition to the temperature of surface waters other epidemiologic factors are also at play, and that there may be an association between waterfowl nesting areas and risk of disease acquisition. We hypothesize that waterfowl serve as reservoirs that maintain the environmental sources of human infection. If this can be shown, control measures can be implemented to reduce the risk of disease acquisition.
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引用次数: 0
Miller Fisher’s telephone effect is a consequence of generative rationality
IF 2.1 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-11-30 DOI: 10.1016/j.mehy.2024.111540
Lana Frankle
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引用次数: 0
Could systemic infections influence the effectiveness of deep brain stimulation therapy in patients with dystonia? 全身感染会影响脑深部刺激疗法对肌张力障碍患者的疗效吗?
IF 2.1 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-11-24 DOI: 10.1016/j.mehy.2024.111527
Valentino Rački , Mario Hero , Eliša Papić , Gloria Rožmarić , Marina Raguž , Darko Chudy , Olivio Perković , Vladimira Vuletić
Dystonia is a movement disorder characterized by sustained or intermittent muscle contractions resulting from aberrant sensory integration, enhanced cortical plasticity, and lack of intracortical inhibition. Deep brain stimulation of the globus pallidus internus (GPi-DBS) effectively treats dystonia, reducing abnormal neural oscillations and improving motor function. However, systemic infections can significantly impact brain function, altering brain wave dynamics and cortical excitability. We hypothesize that dystonia patients treated with DBS exhibit altered cortical excitability and changes in brain wave dynamics during early recovery from systemic infections, necessitating DBS parameters adjustment to prevent symptoms exacerbation. We propose a two-year clinical study involving 15 dystonia patients with DBS capable of local field potential (LFP) recording to evaluate this hypothesis. The study will analyze brain activity patterns, symptom severity and infection impact on neural activity. Continuous and infection-triggered LFP recording will provide data for advanced analysis to identify LFP patterns associated with dystonia symptoms and the effects of infections. This paper underscored the importance of individualized and dynamic DBS management, especially post-infection. Systemic infections can induce neuroinflammation, disrupting neural circuits and increasing brain sensitivity to DBS. Timely DBS adjustments are crucial to mitigate overstimulation and optimize outcomes. Enhanced post-infection care, including thorough evaluations and parameter adjustments, is essential for managing dystonia patients with DBS. Future research into the neuroinflammatory mechanism and their effect on neural circuits will improve our understanding and treatment of dystonia in the context of systemic infections.
肌张力障碍是一种运动障碍疾病,其特征是持续或间歇性肌肉收缩,原因是感觉统合失常、皮质可塑性增强以及皮质内抑制功能缺乏。脑深部刺激苍白球内肌(GPi-DBS)可有效治疗肌张力障碍,减少异常神经振荡,改善运动功能。然而,全身感染会严重影响大脑功能,改变脑电波动态和皮质兴奋性。我们假设,接受 DBS 治疗的肌张力障碍患者在从全身感染中恢复的早期会表现出皮质兴奋性改变和脑电波动态变化,因此有必要调整 DBS 参数以防止症状加重。我们建议开展一项为期两年的临床研究,对 15 名接受 DBS 治疗的肌张力障碍患者进行局部场电位(LFP)记录,以评估这一假设。研究将分析大脑活动模式、症状严重程度和感染对神经活动的影响。连续和感染触发的 LFP 记录将为高级分析提供数据,以确定与肌张力障碍症状和感染影响相关的 LFP 模式。这篇论文强调了个性化和动态 DBS 管理的重要性,尤其是在感染后。全身感染会诱发神经炎症,破坏神经回路,增加大脑对 DBS 的敏感性。及时调整 DBS 对减轻过度刺激和优化疗效至关重要。加强感染后护理,包括全面评估和参数调整,对于管理使用 DBS 的肌张力障碍患者至关重要。未来对神经炎症机制及其对神经回路影响的研究将提高我们对全身感染背景下肌张力障碍的认识和治疗水平。
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引用次数: 0
Cochlear origin of tinnitus and outer hair cell motor protein Prestin as a biomarker for tinnitus 耳鸣的耳蜗起源和作为耳鸣生物标志物的外毛细胞运动蛋白 Prestin
IF 2.1 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-11-22 DOI: 10.1016/j.mehy.2024.111528
Erdoğan Bulut , Murat Arslan , Cem Uzun
Peripheral dysfunction and hearing loss are known risk factors for tinnitus; however, a portion of tinnitus patients exhibit no apparent peripheral auditory deficits. This article proposes that tinnitus may originate in the cochlea due to, undetectable damage to outer hair cells (OHCs) in individuals with normal hearing. The study further suggests that peripheral auditory deficits can be identified through the outer hair cell motor protein Prestin, which has potential as a biomarker for early detection. Minor OHC losses, which do not result in clinically detectable hearing loss, may lead to insufficient depolarization of inner hair cells (IHCs), thereby reducing sensory input along the cochlea-cortex pathway in the central auditory system. From a homeostatic gain control perspective, decreased amplification by OHCs, including abnormal electromotile responses, may lead to inadequate encoding by IHCs, contributing to the cochlear origin of tinnitus. Damage to OHCs that does not affect hearing thresholds, or abnormal electromotile contractions influenced by Prestin, may contribute to peripheral auditory dysfunction underlying tinnitus. As a result, pre-neural mismatched synchronization between OHCs and IHCs, driven by abnormal OHC electromotility, could cause sound processing disorders within the central auditory system. This pathophysiological mechanism at the cochlear level may lead to pathological alterations at multiple levels of the central auditory system. Prestin may serve as a potential biomarker for tinnitus, offering valuable insights into its cochlear origin and guiding future therapeutic developments.
外周功能障碍和听力损失是耳鸣的已知风险因素;然而,部分耳鸣患者并没有表现出明显的外周听觉障碍。本文提出,耳鸣可能起源于耳蜗,原因是听力正常者的外毛细胞(OHC)受到了难以察觉的损伤。研究进一步指出,外周听觉障碍可通过外毛细胞运动蛋白 Prestin 来识别,而 Prestin 有可能成为早期检测的生物标志物。轻微的外毛细胞损失不会导致临床上可检测到的听力损失,但可能会导致内毛细胞去极化不足,从而减少中枢听觉系统中耳蜗-皮质通路的感觉输入。从稳态增益控制的角度来看,外耳毛细胞放大功能的减弱,包括异常的肌电反应,可能会导致内耳毛细胞编码不足,从而导致耳蜗源性耳鸣。不影响听阈的 OHC 损伤或受 Prestin 影响的异常肌电收缩可能会导致耳鸣的外周听觉功能障碍。因此,在异常 OHC 电运动的驱动下,OHC 和 IHC 之间的神经前不匹配同步可能会导致中枢听觉系统的声音处理失调。这种耳蜗层面的病理生理机制可能会导致中枢听觉系统多个层面的病理改变。Prestin 可作为耳鸣的潜在生物标志物,为了解耳蜗的起源提供有价值的见解,并指导未来的治疗发展。
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引用次数: 0
Intense pulsed light alleviates keratoconus by improving the local corneal microenvironment 强脉冲光通过改善局部角膜微环境缓解角膜炎症状
IF 2.1 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-11-19 DOI: 10.1016/j.mehy.2024.111526
Zixiang Zhao , Yu Liu , Yuhao Zou , Yi Liu , Man Yu
Keratoconus (KC) is a corneal ectasia with a complex etiology, and its pathogenesis remains incompletely understood. Research indicates that the development of KC is closely linked to inflammation and local oxidative stress (OS) triggered by alterations in the microenvironment of the ocular surface. Intense pulsed light (IPL) has been shown to enhance the ocular surface microenvironment, decrease inflammatory cytokines, and mitigate oxidative stress associated with KC progression. We hypothesize that IPL may impede the advancement of KC through several mechanisms. IPL treatment could lead to a decrease in inflammatory mediators (such as IL-1, IL-17, IL-6, etc.) in the eyelid margin and ocular surface, as well as a reduction in matrix metalloproteinases (MMPs) levels in tears, while elevating tissue inhibitor of metalloproteinases (TIMPs) levels, thereby slowing down extracellular matrix (ECM) degradation. Moreover, IPL stimulates fibroblasts to upregulate the expression of type I and type III procollagen mRNA and enhance ECM synthesis. Additionally, IPL regulates tear reactive oxygen species (ROS) levels, elevating tissue superoxide dismutase (SOD) levels through light modulation, maintaining the balance between oxidation and antioxidation, and lessening OS-induced damage. Lastly, IPL diminishes the urge of patients to rub their eyes by alleviating the itching sensation. In conclusion, IPL holds promise as a potential therapeutic approach for managing KC.
角膜塑形镜(KC)是一种病因复杂的角膜异位症,其发病机制至今仍未完全明了。研究表明,KC 的发病与炎症和眼表微环境改变引发的局部氧化应激(OS)密切相关。强脉冲光(IPL)已被证明能改善眼表微环境,减少炎症细胞因子,减轻与 KC 进展相关的氧化应激。我们假设 IPL 可通过多种机制阻碍 KC 的发展。IPL 治疗可导致眼睑边缘和眼表面的炎症介质(如 IL-1、IL-17、IL-6 等)减少,泪液中的基质金属蛋白酶(MMPs)水平降低,而金属蛋白酶组织抑制剂(TIMPs)水平升高,从而减缓细胞外基质(ECM)降解。此外,IPL 还能刺激成纤维细胞上调 I 型和 III 型胶原蛋白 mRNA 的表达,促进 ECM 的合成。此外,强脉冲光还能调节泪液中活性氧(ROS)的水平,通过光调节提高组织超氧化物歧化酶(SOD)的水平,维持氧化和抗氧化之间的平衡,减轻操作系统引起的损伤。最后,强脉冲光还能减轻瘙痒感,从而减少患者揉眼的冲动。总之,强脉冲光有望成为控制 KC 的一种潜在治疗方法。
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引用次数: 0
Membrane damage produced by parvovirus B19 tags erythrocytes as senescent and is an aggravating cause of virus-triggered anemias 副病毒 B19 产生的膜损伤会将红细胞标记为衰老红细胞,是病毒引发的贫血症的加重原因之一
IF 2.1 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-11-19 DOI: 10.1016/j.mehy.2024.111524
Josefina Valadez-García , Iris Ashanty Soto-Valerio , Maximiliano Cueva-Berea , Guadalupe Trinidad Zavala-Padilla , Ismael Bustos-Jaimes
Parvovirus B19 (B19V) is the causative agent of erythema infectiosum and other diseases, including aplastic anemia in individuals with underlying hemolytic disorders such as sickle cell disease, spherocytosis or thalassemia. It has been well-established that B19V affects the development of red blood cells (RBC) by infecting erythroid progenitor cells (EPC) in the bone marrow. The first step in B19V infection is the binding of the virion to the glycosphingolipid (GSL) globoside (Gb4) on the EPC surface and temporarily stopping erythropoiesis. Although this infection is tolerated well by healthy patients, it can lead to severe aplastic crises in anemia patients. Gb4 is also the most abundant neutral glycolipid in the erythrocyte membrane. It has been documented that B19V and its virus-like particles (VLP) produce hemagglutination of RBCs. We hypothesized that B19V binding to the RBC membrane must induce changes impairing its function and reducing the cell’s half-life, being an aggravating cause of anemias produced by B19V. Here, we present optic and electronic microscopy evidence of morphological changes on the surface of the RBC produced by the presence of B19V VLP, supporting this hypothesis.
Parvovirus B19(B19V)是红斑性传染性皮肤病和其他疾病的病原体,包括患有镰状细胞病、球形红细胞增多症或地中海贫血症等潜在溶血性疾病的患者的再生障碍性贫血。已经证实,B19V 通过感染骨髓中的红细胞祖细胞(EPC)影响红细胞(RBC)的发育。B19V 感染的第一步是病毒与 EPC 表面的糖磷脂(GSL)球苷(Gb4)结合,暂时停止红细胞生成。虽然健康患者对这种感染的耐受性良好,但它会导致贫血患者出现严重的再生障碍性危机。Gb4 也是红细胞膜上最丰富的中性糖脂。有文献记载,B19V 及其病毒样颗粒(VLP)会对红细胞产生血凝作用。我们推测,B19V 与红细胞膜结合后一定会引起变化,从而损害其功能并缩短细胞的半衰期,这也是 B19V 导致贫血的一个重要原因。在此,我们提出了光学和电子显微镜证据,证明 B19V VLP 的存在会导致 RBC 表面发生形态变化,从而支持了这一假设。
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引用次数: 0
Do skeletal muscles compete with each other for growth? 骨骼肌在生长过程中会相互竞争吗?
IF 2.1 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-11-19 DOI: 10.1016/j.mehy.2024.111525
Ryo Kataoka, Yujiro Yamada, William B. Hammert, Anna Kang, Jeremy P. Loenneke
Within the resistance training literature, a within-subject training model is often used to compare two separate training interventions within the same individual. While this model has some advantages related to statistical power, potential concerns have been raised when investigating changes in muscle strength. Conversely, it is currently believed that muscle growth is driven by local mechanisms. Thus, a within-subject design could potentially still be used if the sole outcome variable is changes in muscle size. What remains less clear, however, is whether the magnitude of skeletal muscle growth with resistance training is negatively influenced by the amount of muscle recruited within a given training period (e.g., upper body exercise only vs. same upper body exercise plus lower body resistance exercises). We hypothesize that there might be a competition for resources on skeletal muscle growth when more muscles are activated within a given training session and/or period, which might be moderated by energy availability. Determining the extent to which muscle exercised during resistance training influences skeletal muscle growth may provide important methodological considerations for researchers and practitioners alike. From a practical sense, if the competition of resources exists, one may benefit from specializing a certain muscle group to train within a given training period while deemphasizing other muscle groups.
在阻力训练文献中,受试者内训练模型通常用于比较同一个体内两种不同的训练干预措施。虽然这种模式在统计能力方面有一些优势,但在研究肌肉力量变化时,也提出了一些潜在的问题。相反,目前认为肌肉生长是由局部机制驱动的。因此,如果唯一的结果变量是肌肉大小的变化,则仍有可能使用受试者内设计。然而,尚不清楚的是,阻力训练中骨骼肌增长的幅度是否会受到特定训练时间内所招募肌肉量的负面影响(例如,仅上半身锻炼与相同的上半身锻炼加下半身阻力锻炼)。我们假设,在特定的训练课和/或训练期间,当更多的肌肉被激活时,骨骼肌的生长可能会出现资源竞争,这可能会受到能量供应的影响。确定阻力训练中肌肉运动对骨骼肌生长的影响程度,可为研究人员和从业人员提供重要的方法论考虑。从实际意义上讲,如果存在资源竞争,那么在特定训练时间内专门训练某一肌肉群,同时不强调其他肌肉群,可能会使人受益。
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引用次数: 0
Topical application of Ringer’s lactate for Stage 1 Retinopathy of Prematurity: A potential treatment hypothesis 局部应用乳酸林格氏液治疗 1 期早产儿视网膜病变:一种潜在的治疗假设
IF 2.1 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-11-17 DOI: 10.1016/j.mehy.2024.111523
Vignesh Elamurugan , Siddharth Narendran , Toshit Varshney , K.Naresh Babu , Renu P Rajan , Pragathi Shankaralingappa , Gopinathan Mathiyazhagan
Retinopathy of Prematurity (ROP) is a disorder affecting the developing retinal vasculature in preterm infants and is one of the major preventable causes of childhood blindness worldwide. The pathogenesis of ROP is characterized by two distinct phases: Phase 1 occurs when preterm infants are exposed to relative hyperoxia compared to in-utero conditions, either from atmospheric oxygen or supplemental therapy. This exposure causes vaso-obliteration and disrupts peripheral retinal vascularization. In Phase 2, the resulting peripheral avascular retina becomes hypoxic, triggering the release of pro-angiogenic factors like VEGF. This leads to proliferative retinopathy, potentially causing complications such as retinal detachment and permanent blindness in affected neonates. Current management strategies in ROP include intravitreal anti-VEGF injections and laser photocoagulation.
Lactate is a well-known pro-angiogenic molecule. We hypothesize that topical administration of lactate in the form of Ringer’s lactate solution in the eye in Phase 1 of ROP would allow normal retinal vascularisation, potentially preventing the progression of ROP to Phase 2. This approach warrants investigation as a potential therapy to reduce the incidence of phase 2 ROP and its complications.
早产儿视网膜病变(ROP)是一种影响早产儿视网膜血管发育的疾病,是全球儿童失明的主要可预防原因之一。早产儿视网膜病变的发病机制分为两个不同的阶段:第一阶段发生在早产儿暴露于相对于胎儿期的高氧环境时,高氧来自大气中的氧气或补充治疗。这种暴露会导致血管闭塞,破坏外周视网膜血管形成。在第二阶段,外周无血管视网膜变得缺氧,引发血管生成因子(如血管内皮生长因子)的释放。这会导致增殖性视网膜病变,有可能引起视网膜脱离等并发症,并导致患病新生儿永久失明。目前治疗视网膜病变的策略包括玻璃体内注射抗血管内皮生长因子和激光光凝。我们假设,在 ROP 第一阶段,以林格氏乳酸盐溶液的形式在眼内局部注射乳酸盐,可使视网膜血管正常化,从而有可能防止 ROP 进展到第二阶段。这种方法作为一种潜在的疗法,可降低 ROP 第 2 期的发病率及其并发症,值得研究。
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引用次数: 0
Transgenic animal models for diagnosis of Disease: A hypothesis 用于疾病诊断的转基因动物模型:一种假设
IF 2.1 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-11-17 DOI: 10.1016/j.mehy.2024.111521
Vala Kafil , Benjamin Sreenan , Farzaneh Naghdi Eshratabad , Xiaoshan Zhu
This paper introduces a novel diagnostic approach for disease discrimination through the development of transgenic animals with highly sensitive olfactory receptor cells. Traditional diagnostic methods, such as enzyme-linked immunosorbent assay (ELISA) and nucleic acid-based amplification assay, face challenges related to false positives/negatives, limited sensitivity, or complex and costly procedures. Building on the advances in olfaction understanding and the documented ability of individuals and animals to detect diseases through scent, we propose a paradigm shift in disease diagnosis. The paper highlights the remarkable case of Joy Milne, who identified a distinct odor associated with Parkinson’s disease, leading to subsequent scientific validation. Building upon such research, we hypothesize that transgenic animals, engineered for heightened olfactory capabilities, could revolutionize disease diagnosis. The molecular recognition process and specificity of olfactory receptor cells are explored to elucidate the potential of transgenic animals in reducing the detection limit in diagnostics. Creating genetically modified animals with overexpressed olfactory receptors holds promise for early disease detection, improving prognosis and treatment outcomes. This innovative approach may significantly impact the core principles of illness diagnosis, opening up new perspectives for research and application in the field of disease diagnosis and treatment strategies.
本文介绍了一种新型疾病诊断方法,即通过培育具有高灵敏度嗅觉受体细胞的转基因动物进行疾病鉴别。传统的诊断方法,如酶联免疫吸附试验(ELISA)和基于核酸的扩增试验,面临着假阳性/阴性、灵敏度有限或程序复杂、成本高昂等挑战。基于对嗅觉理解的进步以及个人和动物通过气味检测疾病的能力记录,我们提出了疾病诊断模式的转变。本文重点介绍了乔伊-米尔恩(Joy Milne)的杰出案例,她发现了一种与帕金森病相关的独特气味,并在随后进行了科学验证。在此类研究的基础上,我们假设,通过改造提高嗅觉能力的转基因动物可以彻底改变疾病诊断。我们对嗅觉受体细胞的分子识别过程和特异性进行了探索,以阐明转基因动物在降低诊断中的检测极限方面的潜力。创造过度表达嗅觉受体的转基因动物有望用于早期疾病检测,改善预后和治疗效果。这种创新方法可能会对疾病诊断的核心原则产生重大影响,为疾病诊断和治疗策略领域的研究和应用开辟新的前景。
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引用次数: 0
The importance of combined Candida & Borrelia biofilms in Lyme’s disease and the value of ultrasound treatment: A medical hypothesis 莱姆病中念珠菌和鲍氏菌联合生物膜的重要性以及超声波治疗的价值:医学假说
IF 2.1 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-11-12 DOI: 10.1016/j.mehy.2024.111522
Jean-Pierre Tournier , Pierre-Yves Marcy , Christian Perronne , Alexis Lacout
The chronic form of Lyme’s disease is gaining general recognition by the CDC in Atlanta.
The factors contributing to the chronicity of this disease are well-documented in the current literature. Biofilms are known being key-factors for the persistence of many infections and thus may explain the passage to further disease’s chronicity. Other mechanisms of bacteria’s persistence into the human host may involve the ecosystem and the Borrelia’s ability to interact with the surrounding microorganisms, like Candida. Moreover, candidiasis could be at the origin of clinical syndromes resembling Lyme’s disease, via the production of mycotoxins. In addition to antibiotic therapy, we hypothesize that the treatment of chronic Lyme’s disease could include the administration of antifungal drugs. It also seems important to evaluate the drugs that could destroy biofilms. An unconventional and original approach could be to add to the conventional therapy mechanical tools to destroying these biofilms by using low-frequency ultrasound.
莱姆病的慢性形式正得到亚特兰大疾病预防控制中心的普遍认可。众所周知,生物膜是许多感染持续存在的关键因素,因此,生物膜可能是导致疾病进一步慢性化的原因。细菌在人类宿主体内持续存在的其他机制可能涉及生态系统以及鲍瑞氏菌与周围微生物(如念珠菌)相互作用的能力。此外,念珠菌病可能是通过产生霉菌毒素而导致类似莱姆病的临床综合征的根源。除了抗生素治疗外,我们还假设慢性莱姆病的治疗可以包括使用抗真菌药物。评估能破坏生物膜的药物似乎也很重要。一种非常规的新方法是在传统疗法的基础上增加机械工具,通过使用低频超声波来破坏这些生物膜。
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引用次数: 0
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Medical hypotheses
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