Clinical asymmetry in Parkinson’s disease is characterized by prevalence of subthalamic pause-burst neurons and alpha-beta oscillations

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2024-06-14 DOI:10.1016/j.clinph.2024.06.003

Philip Pavlovsky , Ksenia Sayfulina , Anna Gamaleya , Alexey Tomskiy , Elena Belova , Alexey Sedov

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Abstract

Objective

We aimed to establish specific biomarkers of Parkinson’s disease (PD) by comparing activity of more affected (MA) and less affected (LA) subthalamic nucleus (STN) of patients with prominent clinical asymmetry.

Methods

We recorded single unit activity and local field potentials (LFP) of the STN during deep brain stimulation surgeries. Neuronal firing patterns and discharge rate, as well as oscillatory features of both single cells and LFP, were analyzed.

Results

We observed notable differences in proportions of irregular-burst and pause-burst, but not tonic neurons, between the hemispheres. Oscillations of pause-burst neurons correlated significantly with the bradykinesia and rigidity scores of the corresponding hemibody. LFP derived from MA STN featured greater power in 12–15 Hz.

Conclusions

Our results provide evidence that the increased proportion of units with prolonged pauses may be associated with PD. We also speculate that some of them may gain rhythmicity in the alpha-beta range in relation to hypokinetic symptoms, long-term disease, or both.

Significance

Our findings highlight the relation between specific oscillatory features of the STN, predominance of subthalamic pause-burst units and PD pathophysiology.

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帕金森病的临床不对称性以丘脑下暂停-爆发神经元和阿尔法-贝塔振荡的流行为特征

目的我们旨在通过比较临床症状明显不对称的患者中患病较多（MA）和患病较少（LA）的丘脑下核（STN）的活动，建立帕金森病（PD）的特异性生物标志物。方法我们在脑深部刺激手术中记录了STN的单细胞活动和局部场电位（LFP）。结果我们观察到两个半球之间不规则爆发和暂停爆发神经元的比例存在显著差异，但强直神经元的比例没有差异。暂停-爆发神经元的振荡与相应半球的运动迟缓和僵直评分显著相关。来自 MA STN 的 LFP 在 12-15 Hz 频率的功率更大。我们还推测，其中一些单元可能在阿尔法-贝塔范围内获得节律性，这与运动功能减退症状、长期疾病或两者都有关系。意义我们的研究结果强调了 STN 的特定振荡特征、丘脑下暂停-爆发单元的优势与帕金森病病理生理学之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.