Auditory brainstem response to paired clicks as a candidate marker of cochlear synaptopathy in humans

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2024-06-15 DOI:10.1016/j.clinph.2024.06.005

Haruna Fujihira , Shimpei Yamagishi , Shigeto Furukawa , Makio Kashino

{"title":"Auditory brainstem response to paired clicks as a candidate marker of cochlear synaptopathy in humans","authors":"Haruna Fujihira , Shimpei Yamagishi , Shigeto Furukawa , Makio Kashino","doi":"10.1016/j.clinph.2024.06.005","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to evaluate whether auditory brainstem response (ABR) using a paired-click stimulation paradigm could serve as a tool for detecting cochlear synaptopathy (CS).</p></div><div><h3>Methods</h3><p>The ABRs to single-clicks and paired-clicks with various inter-click intervals (ICIs) and scores for word intelligibility in degraded listening conditions were obtained from 57 adults with normal hearing. The wave I peak amplitude and root mean square values for the post-wave I response within a range delayed from the wave I peak (referred to as the RMS<sub>post-w1</sub>) were calculated for the single- and second-click responses.</p></div><div><h3>Results</h3><p>The wave I peak amplitudes did not correlate with age except for the second-click responses at an ICI of 7 ms, and the word intelligibility scores. However, we found that the RMS<sub>post-w1</sub> values for the second-click responses significantly decreased with increasing age. Moreover, the RMS<sub>post-w1</sub> values for the second-click responses at an ICI of 5 ms correlated significantly with the scores for word intelligibility in degraded listening conditions.</p></div><div><h3>Conclusions</h3><p>The magnitude of the post-wave I response for the second-click response could serve as a tool for detecting CS in humans.</p></div><div><h3>Significance</h3><p>Our findings shed new light on the analytical methods of ABR for quantifying CS.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7000,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1388245724001779/pdfft?md5=5e7a428c91b1b250d1def22d11412b02&pid=1-s2.0-S1388245724001779-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Neurophysiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1388245724001779","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

This study aimed to evaluate whether auditory brainstem response (ABR) using a paired-click stimulation paradigm could serve as a tool for detecting cochlear synaptopathy (CS).

Methods

The ABRs to single-clicks and paired-clicks with various inter-click intervals (ICIs) and scores for word intelligibility in degraded listening conditions were obtained from 57 adults with normal hearing. The wave I peak amplitude and root mean square values for the post-wave I response within a range delayed from the wave I peak (referred to as the RMS_post-w1) were calculated for the single- and second-click responses.

Results

The wave I peak amplitudes did not correlate with age except for the second-click responses at an ICI of 7 ms, and the word intelligibility scores. However, we found that the RMS_post-w1 values for the second-click responses significantly decreased with increasing age. Moreover, the RMS_post-w1 values for the second-click responses at an ICI of 5 ms correlated significantly with the scores for word intelligibility in degraded listening conditions.

Conclusions

The magnitude of the post-wave I response for the second-click response could serve as a tool for detecting CS in humans.

Significance

Our findings shed new light on the analytical methods of ABR for quantifying CS.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

听觉脑干对配对点击的反应是人类耳蜗突触病的候选标记

本研究旨在评估使用成对点击刺激范式的听性脑干反应（ABR）是否可作为检测耳蜗突触病（CS）的工具。方法从 57 名听力正常的成年人中获得了对单次点击和不同点击间隔（ICI）的成对点击的 ABR 以及在听力下降条件下的单词可懂度评分。计算了单次和二次点击反应的波 I 峰值振幅和波 I 峰值延迟范围内的波 I 后反应的均方根值（称为 RMSpost-w1）。但是，我们发现随着年龄的增长，第二次点击反应的 RMSpost-w1 值明显下降。此外，ICI 为 5 毫秒时第二次点击反应的 RMSpost-w1 值与降级听力条件下的单词可懂度评分有显著相关性。结论第二次点击反应的波后 I 反应的大小可作为检测人类 CS 的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.