Pyrrole and pyrrolidine analogs: The promising scaffold in discovery of pesticides

IF 8.9 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Chinese Chemical Letters Pub Date : 2025-03-01 Epub Date: 2024-06-06 DOI:10.1016/j.cclet.2024.110094
Anjing Liao , Wei Sun , Yaming Liu , Han Yan , Zhi Xia , Jian Wu
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Abstract

Pyrrole is a heterocycle with four carbon atoms and a nitrogen atom, which is extensively used in the pesticide and pharmaceutical industries. In addition, it has a series of analogs such as pyrrolidine, pyrroline, and pyrrolidone. Pesticides containing pyrrole and its analogs have been formally marketed as fungicides, including fenpiclonil, fludioxonil, the insecticide chlorfenapyr, and the herbicide fluorochloridone. In this paper, we analyze the structure-activity relationships (SARs) of pesticides containing these structures. We summarize the characteristics possessed by the most highly active pyrrole and its analogs and provide an overview of research on pyrrole compounds with insecticidal, antimicrobial, herbicidal, and antiviral properties in the past 20 years. It is hoped to provide ideas for the development and design of this type compounds in pesticides and to assist researchers in this area.

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吡咯和吡咯烷类似物:在发现杀虫剂方面大有可为的支架
吡咯是由四个碳原子和一个氮原子组成的杂环化合物,广泛应用于农药和制药工业。此外,它还具有吡咯烷、吡咯啉、吡咯烷酮等一系列类似物。含有吡咯及其类似物的农药已正式作为杀菌剂上市销售,包括苯吡咯尼、氟氧恶菌尼、杀虫剂氯虫腈和除草剂氟氯酮。本文对含有这些结构的农药进行了构效关系分析。本文综述了高活性吡咯及其类似物的特点,并对近20年来吡咯类化合物的杀虫、抗菌、除草和抗病毒等方面的研究进展进行了综述。希望为该类化合物在农药中的开发和设计提供思路,并为该领域的研究人员提供帮助。
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来源期刊
Chinese Chemical Letters
Chinese Chemical Letters 化学-化学综合
CiteScore
14.10
自引率
15.40%
发文量
8969
审稿时长
1.6 months
期刊介绍: Chinese Chemical Letters (CCL) (ISSN 1001-8417) was founded in July 1990. The journal publishes preliminary accounts in the whole field of chemistry, including inorganic chemistry, organic chemistry, analytical chemistry, physical chemistry, polymer chemistry, applied chemistry, etc.Chinese Chemical Letters does not accept articles previously published or scheduled to be published. To verify originality, your article may be checked by the originality detection service CrossCheck.
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