Human T-cell lymphotropic virus screening in France: Missed opportunities? A retrospective multicenter study of serological testing in hospital laboratories

IF 1.5 Q4 INFECTIOUS DISEASES IJID regions Pub Date : 2024-06-13 DOI:10.1016/j.ijregi.2024.100387

Olivier Moquet , Ibrahima Faye , Nicolas Auffret , Benoit Garin , Ségolène Brichler , Raymond Césaire , French study group on HTLV testing practices

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Abstract

Objectives

Human T-lymphotropic virus 1 infection is endemic in the French Antilles, French Guiana, and sub-Saharan Africa, the origin of many immigrants currently living in France. There are no national screening recommendations outside of the regulatory obligations concerning donations of blood, tissue, gametes, or milk to a lactarium. This study aimed to investigate the screening and diagnostic practices for this infection in France.

Methods

Serological statistics for regulatory, antenatal, sexually transmitted infections (for CeGIDDs (Centre Gratuit d'Information, de Dépistage et de Diagnostic des Infections Sexuellement Transmissibles), which are public sexual health clinics), accidental exposure to blood screenings, and diagnosis since January 1, 2018 were collected from 23 hospital laboratories (two in the French Antilles, 21 in mainland France) associated with 55 hospitals and 22 maternity units.

Results

A total absence of antenatal screening was reported by 75% of the laboratories associated with maternity units in mainland France. All the laboratories in mainland France reported an absence of screening in the accidental exposure to blood context, as did all the laboratories in mainland France associated with a CeGIDD in the context of sexually transmitted infection screening. Conversely, screening in accordance with the existing regulations was generally systematically carried out. The most frequently reported diagnostic contexts were hematology and neurology.

Conclusions

This study reveals an underscreening of human T-lymphotropic virus 1 in the hospital laboratories of mainland France.

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法国的 HTLV 筛查：错失良机？医院实验室血清学检测的多中心回顾性研究

目标人类 T 淋巴细胞病毒 1 感染在法属安的列斯群岛、法属圭亚那和撒哈拉以南非洲地区流行，这些地区是目前居住在法国的许多移民的原籍地。除了有关向哺乳室捐献血液、组织、配子或牛奶的监管义务外，目前还没有全国性的筛查建议。本研究旨在调查法国对这种感染的筛查和诊断方法。方法从与 55 家医院和 22 家产科医院相关的 23 家医院实验室（2 家位于法属安的列斯群岛，21 家位于法国本土）收集了自 2018 年 1 月 1 日以来有关监管、产前、性传播感染（CeGIDDs（Centre Gratuit d'Information, de Dépistage et de Diagnostic des Infections Sexuellement Transmissibles），即公共性健康诊所）、意外接触血液筛查和诊断的血清学统计数据。结果75%与法国本土产科医院有关联的实验室报告完全没有进行产前筛查。法国本土的所有实验室均报告未进行意外接触血液筛查，法国本土与 CeGIDD 有关联的所有实验室也报告未进行性传播感染筛查。相反，根据现行法规进行的筛查一般都是系统性的。本研究显示，法国本土医院实验室对人类 T 淋巴细胞病毒 1 的筛查不足。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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