Hao Chen , Hongzhong Xi , Mingbin Guo , Xiaoxue Tan , Peng Xue , Shuai He , Guangquan Sun , Yixuan Huang , Xiaohong Jiang , Bin Du , Xin Liu
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引用次数: 0
Abstract
Porous poly (lactic-co-glycolic acid)/β-tricalcium phosphate icaritin (PTI) scaffold is an ideal alternative for repairing bone defects, but their osteoinductive activity are limited. In this study, we fabricated a MXene (Ti3C2Tx) composite PTI (TPTI) scaffold and evaluated its characterization. We co-cultured the scaffolds with rat bone marrow mesenchymal stem cells to access the biocompatibility and osteogenic potential of the TPTI scaffold under on-demand near-infrared (NIR) irradiation. Then TPTI scaffold was implanted in a femoral condyle defect model to evaluate the osteogenic properties by micro-computed tomography, histological and immunohistochemical analysis. The results of experiments reveal that MPTI scaffold has appropriate spatial structure, suitable mechanical strength, and superior photothermal properties. It can maintain the temperature at 42.0 ± 0.5 °C and promote the release of ICT from scaffold under 0.85 W cm−2 NIR irradiation. Furthermore, the scaffold is biocompatible and could promote cell proliferation, osteogenic differentiation, and biomineralization in vitro, as well as the repair of bone defects in vivo, and its effect is further enhanced under NIR irradiation. In conclusion, the MPTI scaffold has the potential to be applied in bone defects repairing, and its osteogenic property can be promoted under NIR irradiation through mild photothermal therapy.
期刊介绍:
Materials and Design is a multi-disciplinary journal that publishes original research reports, review articles, and express communications. The journal focuses on studying the structure and properties of inorganic and organic materials, advancements in synthesis, processing, characterization, and testing, the design of materials and engineering systems, and their applications in technology. It aims to bring together various aspects of materials science, engineering, physics, and chemistry.
The journal explores themes ranging from materials to design and aims to reveal the connections between natural and artificial materials, as well as experiment and modeling. Manuscripts submitted to Materials and Design should contain elements of discovery and surprise, as they often contribute new insights into the architecture and function of matter.