Targeted drug delivery system for Golgi apparatus's diseases

Abstract

Golgi apparatus (GA) is an organelle widely present in eukaryotic cells and involved in a variety of cellular physiological activities, including but not limited to protein modification and secretion. There is increasing evidence that structural or functional disorders of the GA are closely associated with the occurrence and development of diseases. As potential therapeutic targets, researchers have developed GA-targeted drug delivery systems (DDS) for disease treatment. Compared with traditional therapy, DDS achieves remarkable curative effect with high specificity, low dose, reduced drug resistance and side effects, via the alterations in GA morphology or biosynthesis. Therefore, GA-targeted therapy is of great clinical significance and has broad application prospects. In this review, the structure and function of GA are briefly introduced, and mechanisms of DDS entering cells and binding to the GA is classified. Then the typical applications of GA-targeted DDS in the diagnosis and treatment of cancer, cardiovascular diseases, fibrosis, infectious diseases and neurodegenerative diseases is introduced in detail, displaying its great potential in disease treatment. At last, the bottlenecks and future development of this field are discussed. It is our hope that this review will inspire the development of GA-based DDS for clinical applications in the foreseeable future.