Parsing evoked and induced gamma response differences in Autism: A visual evoked potential study

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2024-06-08 DOI:10.1016/j.clinph.2024.05.015

Abigail Dickinson , Declan Ryan , Gabrielle McNaughton , April Levin , Adam Naples , Heather Borland , Raphael Bernier , Katarzyna Chawarska , Geraldine Dawson , James Dziura , Susan Faja , Natalia Kleinhans , Catherine Sugar , Damla Senturk , Frederick Shic , Sara Jane Webb , James C. McPartland , Shafali Jeste , for the Autism Biomarkers Consortium for Clinical Trials

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Abstract

Objective

Electroencephalography (EEG) measures of visual evoked potentials (VEPs) provide a targeted approach for investigating neural circuit dynamics. This study separately analyses phase-locked (evoked) and non-phase-locked (induced) gamma responses within the VEP to comprehensively investigate circuit differences in autism.

Methods

We analyzed VEP data from 237 autistic and 114 typically developing (TD) children aged 6–11, collected through the Autism Biomarkers Consortium for Clinical Trials (ABC-CT). Evoked and induced gamma (30–90 Hz) responses were separately quantified using a wavelet-based time–frequency analysis, and group differences were evaluated using a permutation-based clustering procedure.

Results

Autistic children exhibited reduced evoked gamma power but increased induced gamma power compared to TD peers. Group differences in induced responses showed the most prominent effect size and remained statistically significant after excluding outliers.

Conclusions

Our study corroborates recent research indicating diminished evoked gamma responses in children with autism. Additionally, we observed a pronounced increase in induced power. Building upon existing ABC-CT findings, these results highlight the potential to detect variations in gamma-related neural activity, despite the absence of significant group differences in time-domain VEP components.

Significance

The contrasting patterns of decreased evoked and increased induced gamma activity in autistic children suggest that a combination of different EEG metrics may provide a clearer characterization of autism-related circuitry than individual markers alone.

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解析自闭症患者的诱发和诱导伽马反应差异：视觉诱发电位研究

目的脑电图（EEG）测量视觉诱发电位（VEP）为研究神经回路动态提供了一种有针对性的方法。本研究分别分析了视觉诱发电位中的锁相（诱发）和非锁相（诱发）伽马反应，以全面研究自闭症的神经回路差异。方法我们分析了自闭症生物标记临床试验联盟（ABC-CT）收集的 237 名自闭症儿童和 114 名 6-11 岁典型发育（TD）儿童的视觉诱发电位数据。使用基于小波的时频分析分别量化了诱发和诱导伽马（30-90 Hz）反应，并使用基于置换的聚类程序评估了组间差异。诱导反应的群体差异显示出最显著的效应大小，在排除异常值后仍具有统计学意义。结论我们的研究证实了最近的研究表明自闭症儿童的诱发伽马反应减弱。此外，我们还观察到诱发电位明显增加。意义自闭症儿童诱发伽马活动减少和诱导伽马活动增加的对比模式表明，与单个标记物相比，不同脑电图指标的组合可更清晰地描述自闭症相关回路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.