The association of breastfeeding duration on metabolic syndrome among children and adolescents, stratified by birth weight for gestational age

IF 2.7 3区医学 Q1 PEDIATRICS Pediatric Obesity Pub Date : 2024-06-18 DOI:10.1111/ijpo.13145

Wen Yuan, Jianuo Jiang, Sha-sha Song, Jieyu Liu, Manman Chen, Qiaoxin Shi, Yi Zhang, Li Chen, Yang Qin, Ruolin Wang, Tongjun Guo, Xinxin Wang, Qi Ma, Yanhui Dong, Jun Ma

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Abstract

Background and Objectives

This study aimed to examine the associations between breastfeeding duration and metabolic syndrome (MetS) in adolescents and to further investigate the role of birth weight for gestational age (GA) on these associations.

Methods

A total of 10 275 participants aged 7 to 18 years were included applying multistage cluster random sampling from a Chinese national survey. Birth weight was classified into small for GA (SGA), appropriate for GA (AGA) and large for GA (LGA). Information was collected through a self-administered questionnaire, physical examination and blood biochemical examination. Multivariable linear regression, logistic regression models, restricted cubic spline models were applied to assess the relationships of breastfeeding duration and MetS with different birth weight for GA.

Results

The prevalence of non-breastfeeding, 0–5, 6–12 and >12 months groups were 16.2%, 23.1%, 42.5% and 18.2%, and the prevalence of SGA and LGA was 11.9% and 12.7%, respectively. Prolonged breastfeeding duration was associated with higher odds of MetS (β: 0.08, 95% CI: 0.03, 0.13), WC (β: 3.49, 95% CI: 2.82, 4.16) and SBP (β: 2.34, 95% CI: 1.80, 2.89). SGA and prolonged breastfeeding synergistically increased MetS risks, but LGA appeared to offset the adverse effects of prolonged breastfeeding.

Conclusion

Prolonged breastfeeding may increase children's MetS risks. SGA synergies with prolonged breastfeeding increased MetS burden in children and adolescents, while LGA mitigated the risks. This reminds us that intensive attention should be paid to both early birth weight and subsequent living environment for children and adolescents' lifelong health.

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母乳喂养时间与儿童和青少年代谢综合征的关系（按胎龄体重分层）。

背景和目的：本研究旨在探讨母乳喂养持续时间与青少年代谢综合征（MetS）之间的关系，并进一步研究胎龄体重（GA）对这些关系的影响：方法：采用多阶段整群随机抽样方法，从中国一项全国性调查中纳入了 10 275 名 7 至 18 岁的参与者。出生体重分为小胎龄（SGA）、适龄（AGA）和大胎龄（LGA）。通过自填问卷、体格检查和血液生化检查收集信息。应用多变量线性回归、逻辑回归模型、限制性立方样条模型评估母乳喂养时间和 MetS 与不同出生体重的 GA 的关系：非母乳喂养、0-5 个月、6-12 个月和大于 12 个月组的患病率分别为 16.2%、23.1%、42.5% 和 18.2%，SGA 和 LGA 的患病率分别为 11.9% 和 12.7%。延长母乳喂养时间与较高的 MetS（β：0.08，95% CI：0.03，0.13）、WC（β：3.49，95% CI：2.82，4.16）和 SBP（β：2.34，95% CI：1.80，2.89）几率相关。SGA和长期母乳喂养协同增加了MetS风险，但LGA似乎抵消了长期母乳喂养的不利影响：结论：长期母乳喂养可能会增加儿童患 MetS 的风险。SGA与长期母乳喂养的协同作用增加了儿童和青少年的 MetS 负担，而 LGA 则减轻了风险。这提醒我们，为了儿童和青少年的终生健康，应密切关注早期出生体重和随后的生活环境。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.