UVB-Aged Microplastics and Cellular Damage: An in Vitro Study

IF 3.7 4区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Archives of Environmental Contamination and Toxicology Pub Date : 2024-06-19 DOI:10.1007/s00244-024-01073-x
Sebastiano La Maestra, Mirko Benvenuti, Stefano Alberti, Linda Ferrea, Francesco D’Agostini
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Abstract

Plastics are synthetic organic compounds whose widespread use generates enormous waste. Different processes, such as mechanical abrasion, microbiological activity, and UVB irradiation, can fragment the plastic material and generate microplastics (MPs). MPs are ubiquitous, and various organisms, including humans, can ingest or inhale them, with potential adverse health effects. The differences between UV-aged and virgin particles were studied to evaluate the genotoxic damage and oxidative stress induced by polystyrene MPs with 1 and 5 µm sizes on the monocyte-like cell line (THP-1). Fourier transform infrared spectroscopy and Ζ-potential measurements were used to characterise MP particles after UVB exposure. Cells exposed to MPs show a widespread change in the cellular environment with the generation of reactive oxidative species (ROS), as indicated by the increased malondialdehyde level. The occurrence of genotoxic damage is correlated to the smaller size and ageing state of the MPs. The biochemical and genomic alterations observed in this in vitro study suggest that MPs, ubiquitous pollutants, following natural degradation and oxidation processes can cause various adverse effects on the health of the exposed population, making it necessary to carry out further studies to better define the real risk.

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紫外线老化微塑料与细胞损伤:体外研究
塑料是一种合成有机化合物,其广泛使用会产生大量垃圾。不同的加工过程,如机械磨损、微生物活动和紫外线照射,都会使塑料材料破碎并产生微塑料(MPs)。微塑料无处不在,包括人类在内的各种生物都可能摄入或吸入微塑料,从而对健康造成潜在的不良影响。研究人员对紫外线老化颗粒和原始颗粒之间的差异进行了研究,以评估 1 微米和 5 微米大小的聚苯乙烯微塑料对单核细胞样细胞系(THP-1)诱导的基因毒性损伤和氧化应激。傅立叶变换红外光谱法和Ζ电位测量法用于描述紫外线照射后 MP 粒子的特征。暴露于 MPs 的细胞显示出细胞环境的广泛变化,产生了活性氧化物(ROS),丙二醛含量的增加就表明了这一点。基因毒性损伤的发生与 MPs 较小的尺寸和老化状态有关。在这项体外研究中观察到的生化和基因组变化表明,MPs 作为无处不在的污染物,经过自然降解和氧化过程后,会对暴露人群的健康造成各种不利影响,因此有必要开展进一步研究,以更好地确定实际风险。
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来源期刊
CiteScore
7.00
自引率
2.50%
发文量
63
审稿时长
8-16 weeks
期刊介绍: Archives of Environmental Contamination and Toxicology provides a place for the publication of timely, detailed, and definitive scientific studies pertaining to the source, transport, fate and / or effects of contaminants in the environment. The journal will consider submissions dealing with new analytical and toxicological techniques that advance our understanding of the source, transport, fate and / or effects of contaminants in the environment. AECT will now consider mini-reviews (where length including references is less than 5,000 words), which highlight case studies, a geographic topic of interest, or a timely subject of debate. AECT will also consider Special Issues on subjects of broad interest. The journal strongly encourages authors to ensure that their submission places a strong emphasis on ecosystem processes; submissions limited to technical aspects of such areas as toxicity testing for single chemicals, wastewater effluent characterization, human occupation exposure, or agricultural phytotoxicity are unlikely to be considered.
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