{"title":"Disarming the defenses: Insect detoxification of plant defense-related specialized metabolites","authors":"Kristina Kshatriya, Jonathan Gershenzon","doi":"10.1016/j.pbi.2024.102577","DOIUrl":null,"url":null,"abstract":"<div><p>The ability of certain insects to feed on plants containing toxic specialized metabolites may be attributed to detoxification enzymes. Representatives of a few large families of detoxification enzymes are widespread in insect herbivores acting to functionalize toxins and conjugate them with polar substituents to decrease toxicity, increase water solubility and enhance excretion. Insects have also developed specific enzymes for coping with toxins that are activated upon plant damage. Another source of detoxification potential in insects lies in their microbiomes, which are being increasingly recognized for their role in processing plant toxins. The evolution of insect detoxification systems to resist toxic specialized metabolites in plants may in turn have selected for the great diversity of such metabolites found in nature.</p></div>","PeriodicalId":11003,"journal":{"name":"Current opinion in plant biology","volume":null,"pages":null},"PeriodicalIF":8.3000,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1369526624000682/pdfft?md5=e23c13f2d38ea652baec31be1e2ae144&pid=1-s2.0-S1369526624000682-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in plant biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1369526624000682","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
The ability of certain insects to feed on plants containing toxic specialized metabolites may be attributed to detoxification enzymes. Representatives of a few large families of detoxification enzymes are widespread in insect herbivores acting to functionalize toxins and conjugate them with polar substituents to decrease toxicity, increase water solubility and enhance excretion. Insects have also developed specific enzymes for coping with toxins that are activated upon plant damage. Another source of detoxification potential in insects lies in their microbiomes, which are being increasingly recognized for their role in processing plant toxins. The evolution of insect detoxification systems to resist toxic specialized metabolites in plants may in turn have selected for the great diversity of such metabolites found in nature.
期刊介绍：
Current Opinion in Plant Biology builds on Elsevier's reputation for excellence in scientific publishing and long-standing commitment to communicating high quality reproducible research. It is part of the Current Opinion and Research (CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy - of editorial excellence, high-impact, and global reach - to ensure they are a widely read resource that is integral to scientists' workflow.
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